Slide 17: PB of thalassemia

RBCs: marked poikilocytosis, anisocytosis, and polychromatophilia. The predominant poikilocyte is the leptocyte or target cell. The poikilocytes of hemolysis are also seen: acanthocytes, spherocytes, burr cells, and schistocytes. Moderate to marked basophilic strippling is seen in both the nucleated and non-nucleated forms of erythrocytes. Nucleated RBCs which are almost invariably present are often numerous and may outnumber the leukocytes. The last two nucleated RBC stages, the polychromic normoblast and orthochromic normoblasts, are the predominant forms seen. The first two nucleated stages of RBCs, the basophilic normoblasts and pronormoblasts, are rarely seen. Reticulocytosis is usually present and may be quite high, e.g., 20% or greater. The signs of active normoblasts in erythropoiesis are in evidence: Howell-Jolly bodies, polychromatophilia, and nucleated RBCs.

Leukocyte: Leucocyte counts range from 10,000-25,000/mm3, and occasionally present in immature form.

Figure 1:

說明: marked poikilocytosis, anisocytosis, and polychromatophilia.

marked poikilocytosis, anisocytosis, and polychromatophilia.

Figure 2:

說明: leptocyte and target cell.

The predominant poikilocyte is the leptocyte or target cell.

Figure 3:

說明: acanthocytes, spherocytes, burr cells, and schistocytes.

The poikilocytes of hemolysis are also seen: acanthocytes, spherocytes, burr cells, and schistocytes.

Figure 4:

說明: The predominant poikilocyte is the leptocyte or target cell.

Prominant poikilocyte is the leptocyte or target cell.

Figure 5:

說明: basophilic strippling.

Moderate to marked basophilic strippling is seen in both the nucleated and non-nucleated forms of erythrocytes.

Figure 6:

說明: nucleated RBC

The last two nucleated RBC stages, the polychromic normoblast and orthochromic normoblasts, are the predominant forms seen. The first two nucleated stages of RBCs, the basophilic normoblasts and pronormoblasts, are rarely seen.

Figure 7:

說明: Reticulocytosis - demonstrated by new methylene blue stain.

Reticulocytosis is usually present and may be quite high, e.g., 20% or greater.

Figure 8:

說明:

The signs of active normoblasts in erythropoiesis are in evidence: Howell-Jolly bodies, polychromatophilia, and nucleated RBCs.

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