Slide 18: PB of megaloblastic anemia

	Peripheral blood: Macrocytic anemia; The leukocyte and platelet count also may be decreased, particularly in severely anemic patients.
	RBC: marked anisocytosis and poikilocytosis, together with macroovalocytes, which are large, oval, fully hemoglobinized erythrocytes typical of megaloblastic anemias. There is some basophilic stippling, and an occasional nucleated RBC may be seen.
	WBC: the neutrophils show hypersegmentation of the nucleus. This is such a characteristic finding that a single cell with a nucleus of six lobes or more should raise the immediate suspicion of a megaloblastic anemia. A rare myelocyte also may be seen.
	Platelet: Bizarre, misshapen platelets are also observed.

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