Slide 19: BM of megaloblastic anemia

Hypercellular
Decreased myeloid/erythroid ratio and abundant stainable iron.
RBC precursors:
abnormally large and have nuclei that appear much less mature than would be expected from the development of the cytoplasm (nuclear-cytoplasmic asynchrony).
Abnormal mitoses may be seen.
Granulocyte precursors:
many being larger than normal, including giant bands and metamyelocytes.
Megakaryocytes are decreased and show abnormal morphology.

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