研究主題:
- 雷擊頭痛及可逆性腦血管收縮症候群之臨床、影像及分子生物學研究
RCVS是最嚴重最危險的複雜性神經血管疾病之一,其主要臨床表現為反覆發作如爆炸般的頭痛(雷擊頭痛)合併血管收縮,這些劇烈頭痛讓病患嚴重失能、反覆至急診就診、甚至因此害怕從事這些日常生活活動,影響生活甚鉅,且病患有相當風險產生缺血性中風、腦出血或腦後方白質病變等併發症。針對RCVS,我們從釐清其臨床表現與病程、建立檢查與治療標準流程準則、找出其預測併發症的準則及長期預後、 開發新影像技術協助診治乃至病生理機轉的探討,已發表系列論文於國際知名期刊如JAMA Neurology, Annals of Neurology, Neurology, Cephalalgia等,研究成果質與量居國際領先地位。目前團隊正致力於開發新的影像診斷工具及深入探討其病生理機轉。
- 偏頭痛病生理機轉之生物標記、動物模式、腦連結體及基因體學研究。
偏頭痛是造成最多疾病負擔的神經科疾病,造成的失能人年數在世界所有慢性疾病裡排名第二,對社會經濟與醫療體系造成巨大的衝擊,但其病生理機轉尚未釐清,治療選擇亦有限。團隊目前主要成果為建立偏頭痛動物模式探討偏頭痛的病生理機轉,促進瞭解偏頭痛新的病生理機轉及開發新的治療標的成果發表於Brain, Pain, JCBFM等雜誌。亦發表了台灣第一個也是亞洲唯一一個偏頭痛全基因體關聯性研究,找到台灣人偏頭痛特有的基因,提供未來病生理機轉研究重要方向。目前正持續透過臨床或基礎的研究,開發新的頭痛動物模式及深入探討偏頭痛基因體與腦連結體間的交互影響,希望未來可提供疾病新診斷或治療之契機,進而減輕病患及醫療體系負擔。
得獎紀錄
2022 科技部110年度傑出研究獎
2022 台北榮民總醫院醫師學術論文獎
2022 國立陽明交通大學醫學系優良教師獎
2021 第17屆永信李天德基金會青年醫藥科技獎
2021 台北榮民總醫院醫療創新(改良)獎第一名
2021 國立陽明大學醫學院院級教學傑出獎
2021 國立陽明大學臨床醫學研究所教學傑出教師
2021 國立陽明大學醫學系優良教師
2020 國立陽明大學醫學院院級教學傑出獎
2020 國立陽明大學研究所票選特色教學傑出獎
2020 國立陽明大學臨床醫學研究所優良教師獎
2020 國立陽明大學醫學系優良教師獎
2019 科技部吳大猷先生紀念獎
2019 國立陽明大學醫學系優良教師獎
2019 國立陽明大學臨床醫學研究所「優良教師獎」
2019 國立陽明大學院級教學傑出獎
2019 行政院退輔會台北榮民總醫院優良醫師「醫師學術論文獎」
2018 國立陽明大學醫學系優良教師獎
2018 行政院退輔會台北榮民總醫院優良醫師獎
2018 國際疼痛研究學會官方雜誌(Pain)最高引用次數學術論文獎
2018 國立陽明大學醫學系良師益友導師獎
2017 國立陽明大學醫學系優良教師獎 (琉璃獎座)
2016 國立陽明大學醫學系優良教師獎
2016 行政院退輔會台北榮民總醫院優良醫師「臨床教學績優醫師獎」
2015 國立陽明大學醫學系優良教師獎
2013 榮陽卓越醫師人才培育計畫獎助
2011 行政院退輔會台北榮民總醫院優良醫師「醫師學術論文獎」
2009 行政院退輔會台北榮民總醫院優良醫師「臨床教學績優醫師獎」
2009 台灣神經學會頭痛學組最佳壁報論文獎
2008 台灣神經學會頭痛學組最佳壁報論文獎
2006 台灣神經學會頭痛學組最佳壁報論文獎
Representative publications
- Chen SP, Fuh JL, Lirng JF, Chang FC, Wang SJ.* Recurrent primary thunderclap headache and benign CNS angiopathy: spectra of the same disorder? Neurology. 2006;67:2164-9
- Chen SP,Fuh JL, Chang FC, Lirng JF, Shia BC, Wang SJ.* A transcranial color doppler study for reversible cerebral vasoconstriction syndromes. Annals of Neurology 2008; 63: 751-7.
- Chen SP,Fuh JL, Wang SJ,* Chang FC, Lirng JF, Fang YC, Shia BC, Wu JC. Magnetic resonance angiography in reversible cerebral vasoconstriction syndromes. Annals of Neurology 2010; 67: 648-56.
- Chen SP, Chung YT, Liu TY, Wang YF, Fuh JL,* Wang SJ.* Oxidative stress and increased formation of vasoconstricting F2-isoprostanes in patients with reversible cerebral vasoconstriction syndrome. Free Radical Biology & Medicine. 2013;61C:243-248.
- Chen SP, Fuh JL, Lirng JF, Wang YF, Wang SJ.* Recurrence of Reversible Cerebral Vasoconstriction Syndrome: a Long-Term Follow-up Study. Neurology2015; 84: 1-7
- Chen SP,* Ay I, Lopes de Morais A, Qin T, Zheng Y, Sadeghian H, Oka F, Simon B, Eikermann-Haerter K, Ayata C. Vagus nerve stimulation inhibits cortical spreading depression. Pain2016; 157: 797-805
- Chen SP¶, Fuh JL¶, Chung MY¶, Lin YC, Liao YC, Wang YF, Hsu CL, Yang YC, Lin MW, Chiou JJ, Wang PJ, Chen PK, Fan PC, Wu JY, Chen YT, Kao LS*, Fann CS*, Wang SJ*. Genome-wide association study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan.Cephalalgia 2018; 38: 466-75
- Chen SP, Qin T, Seidel JL, Zheng Y, Eikermann M, Ferrari MD, van den Maagdenberg AM., Moskowitz MA, Ayata C, Eikermann-Haerter K. Inhibition of the P2X7-pannexin 1 complex suppresses spreading depolarization and neuroinflammation. Brain2017; 140:1643-1656
- Chen SP,* Chou KH,¶Fuh JL,¶ Huang YH, Huang CC, Lirng JF, Wang YF, Lin CP, Wang SJ.* Dynamic Changes in White Matter Hyperintensities in Reversible Cerebral Vasoconstriction Syndrome. JAMA Neurology 2018;75(9):1106-1113. (*Equal contribution; ¶Equal contribution)
- Yalcin N¶, Chen SP¶, Yu ES, Liu TT, Yen JC, Atalay YB, Qin T, Celik F, van den Maagdenberg AM, Moskowitz MA, Ayata C, Eikermann-Haerter K*. Caffeine does not affect susceptibility to cortical spreading depolarization in mice. J Cereb Blood Flow Metab2019 Apr;39(4):740-750. (¶Equal contribution)
- Cho SH¶, Ling YH¶, Lee MJ¶, Chen SP¶, Fuh L, Lirng JF, Cha JH, Wang YF, Wang SJ*, Chung CS*. Temporal profile of blood-brain barrier breakdown in reversible cerebral vasoconstriction syndrome. Stroke 2020 May;51(5):1451-1457. (¶Equal contribution; * Equal contribution
- Wu CH, Lirng JF, Ling YH, Wang YF, Wu HM, Fuh JL, Lin PC, Wang SJ*, Chen SP*. Noninvasive characterization of human glymphatics and meningeal lymphatics in an in vivo model of blood-brain barrier leakage. Annals of Neurology 2021;89:111–124
- Chen SP, Chang YA, Chou CH, Juan CC, Lee HC, Chen LK, Wu PC, Wang YF, Fuh JL, Lirng JF, Ducros A, Huang HD*, Wang SJ*. Circulating microRNAs associated with Reversible Cerebral Vasoconstriction Syndrome. Annals of Neurology 2021;89:459–473
- Lee ZF, Huang TH, Chen SP*, Cheng IH*. Altered nociception in Alzheimer disease is associated with striatal-enriched protein tyrosine phosphatase signaling. Pain 2021 Jun 1;162(6):1669-1680. (*Equal contribution)
- Ling YH, Wang YF, Lirng JF, Fuh JL, Wang SJ, Chen SP*. Post-reversible cerebral vasoconstriction syndrome headache. The Journal of Headache and Pain. 2021; 22(1): 1-8
- Lin PT, Wang YF, Fuh JL, Lirng JF, Ling YH, Chen SP*, Wang SJ*. Diagnosis and Classification of Headache Associated with Sexual Activity Using a Composite Algorithm: a cohort study. Cephalalgia 2021 Dec;41(14):1447-1457 (*Equal contribution)
- Tsao YC, Wang SJ, Hsu CL, Wang YF, Fuh JL, Chen SP*, Fann CSJ*. Genome-wide association study reveals susceptibility loci for self-reported headache in a large community-based Asian population Cephalalgia 2021 in press. (*Equal contribution)
- Wu CH, Wu HM, Ling YH, Wang YF, Fuh JL, Lin CJ, Ling K, Lirng JF, Wang SJ*, Chen SP*. Blood brain barrier permeability in patients with reversible cerebral vasoconstriction syndrome assessed with dynamic contrast-enhanced MRI. Neurology 2021 Nov 2;97(18):e1847-e1859. (*Equal contribution)
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Chen SP*, Wang SJ. Pathophysiology of reversible cerebral vasoconstriction syndrome. Journal of Biomedical Science. 2022; 29:72
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Chen SP, Hsu CL, Wang YF, Yang FC, Chen TH, Huang JH, Pan LLH, Fuh JL, Chang HC, Lee YL, Chang HC, Lee KH, Chang YC, Fann CSJ, Wang SJ. Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan. The Journal of Headache and Pain 2022; 23:147. https://doi.org/10.1186/s10194-022-01517-6
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Jiang YJ, Fann CSJ; Fuh JL, Chung MY, Huang HY, Chu KC, Wang YF, Hsu CL, Kao LS, Chen SP*, Wang SJ*. Genome-wide analysis identified novel susceptible genes of restless legs syndrome in migraineurs. The Journal of Headache and Pain. 2022 Mar 29;23(1):39 doi: 10.1186/s10194-022-01409-9. (*equal contribution).
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Chou TM, Lee ZF, Wang SJ, Lien CC*, Chen SP*. CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine. The Journal of Headache and Pain. 2022 in press (*equal contribution)
Review Articles
- Chen SP, Fuh JL, Wang SJ.* Reversible cerebral vasoconstriction syndromes- an under-recognised clinical emergency. Ther Adv Neurol Disord 2010; 3: 161-71.
- Chen SP, Fuh JL, Wang SJ.* Reversible cerebral vasoconstriction syndromes: Current and future perspectives. Expert Rev Neurother 2011; 11:1265-76.
- Chen SP, Ayata C.* Spreading Depression in Primary and Secondary Headache Disorders. Current Pain and Headache Reports. 2016; 20(7):44.
- Chen SP, Tolner EA,* Eikermann-Haerter K.* Animal models of monogenic migraine. Cephalalgia 2016; 36: 704-21
- Chen SP, Ayata C.* Novel Therapeutic Targets against Spreading Depression. Headache 2017;57:1340-1358.
- Chou TM, Chen SP*. Animal Models of Chronic Migraine. Current Pain and Headache Reports. 2018: 19;22(6):44.
- Harriott AM, Takizawa T, Chung DY, Chen SP*. Spreading Depression as a Model of Migraine. The Journal of Headache and Pain 2019;20(1):45.
- Tolner E. *, Chen SP, Eikermann-Haerter K. Current understanding of cortical structure and function in headache. Cephalalgia 2019; 39(13):1683-1699
- Chen SP, Eikermann-Haerter K.* How imaging can help us better understand the migraine-stroke connection. Headache 2020 Jan;60(1):217-228.
Textbook Chapters
- Chen SP, Pascual J, Wang SJ. Chapter 25: Exertional and Sex Headache– In Michel Ferrari, Joost Haan, Andrew Charles, David Dodick, and Fumihiko Sakai (eds.), Oxford Textbook of Headache Syndromes (Oxford Textbooks in Clinical Neurology), Oxford Press, 2016
- Chen SP, Wang SJ. Chapter 15. Reversible cerebral vasoconstriction syndrome. International Neurology. 2nd 2016; DOI: 10.1002/9781118777329.ch15 (Publisher: Wiley-Blackwell)
- Chen SP, Theriot J, Brennan KC, Ayata C. Chapter 19. Animal model of migraine aura. Neurobiologic Basis of Migraine. 1st Edited by Turgay Dalkara and Michael A. Moskowitz. JohnWiley & Sons, Inc. 2017
- Chen SP, Wang SJ. Headaches due to vascular disorders. Modern Day Management of Headache- Questions and Answers. Edited by K Ravishankar, Randolph W Evans and Shuu-Jiun Wang. Jaypee- The Health Science Publisher, 2017
- Takizawa T, Ayata C, Chen SP*. Therapeutic implications of cortical spreading depression models in migraine in Progress in Brain Research. Edited by Lau and Shuu-Jiun Wang. 2020 Elsevier B.V.