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陳明翰 (Ming-Han Chen)


  • 學歷
    日本東京大學 醫學系研究科內科學 博士
    中國醫藥大學 西醫學系 學士
  • 經歷
    • - 迄今 臺北榮民總醫院 內科部過敏免疫風濕科 主治醫師(2014/11~)
    • - 迄今 國立陽明大學 醫學系 教授(2022/2~)
    • - 迄今 臺北榮總 內科部過敏免疫風濕科 科主任(2022/3~)
    • - 日本東京大學 研究支援推進員(2000/11-2001/3)
    • - 國立陽明大學附設醫院 主治醫師(2012/8-2014/10)
  • 醫療專長
    1. 類風濕性關節炎、僵直性脊椎炎、紅斑性狼瘡、乾燥症、異位性皮膚炎、痛風、退化性關節炎、骨質疏鬆症
  • 證照
    中華民國內科專科醫師 中華民國風濕病專科醫師 中華民國過敏免疫專科醫師



Ming-Han Chen, Ming-Huang Chen, Chun-Yu Liu, Chang-Youh Tsai, De-Feng Huang, Hsiao-Yi Lin, Mei-Hsuan Lee, Yi-Hsiang Huang. Hepatitis B Virus Reactivation in Rheumatoid Arthritis Patients undergoing Biologics Treatment. J Infect Dis. 2017;215:566-573. (IF 5.226).

Chen MH, Kan HT, Liu CY, Yu WK, Lee SS, Wang JH, Hsieh SL. Serum decoy receptor 3 is a biomarker for disease severity in nonatopic asthma patients. J Formos Med Assoc. 2017 Jan;116(1):49-56. (IF 3.282)

Li TH, Liao HT, Huang YF, Shen YC, Chiu YC, Chen WS, Chen MH, Tsai CY, Chang DM. The current status and unmet nfoxfeeds in the management of psoriatic arthritis: Viewpoint from physicians in Taiwan. J Formos Med Assoc. 2018 May;117(5):404-412

Huang SF, Chen MH, Wang FD, Tsai CY, Fung CP, Su WJ. Efficacy of isoniazid salvage therapy for latent tuberculosis infection in patients with immune-mediated inflammatory disorders - A retrospective cohort study in Taiwan. J Microbiol Immunol Infect. 2018;51:784-793.

Chiu HY, Lin LY, Chou WC, Fang WL, Shyr YM, Yeh YC, Mu-Hsin Chang P, Chen MH, Hung YP, Chao Y, Chien SH, Chen MH. Toxicities, safeties and clinical response of dacarbazine-based chemotherapy on neuroendocrine tumors in Taiwan population. J Chin Med Assoc. 2017 Dec 26. pii: S1726-4901(17)30341-6.

Chen MH, Lee MH, Liao HT, Chen WS, Lai CC, Tsai CY. Health-related quality of life outcomes in patients with rheumatoid arthritis and ankylosing spondylitis after tapering biologic treatment. Clin Rheumatol. 2018 Feb;37(2):429-438. (IF 2.980) 被引用 19 次

Yeh CN, Chang YC, Su Y, Shin-Shian Hsu D, Cheng CT, Wu RC, Chung YH, Chiang KC, Yeh TS, Lu ML, Liu CY, Mu-Hsin Chang P, Chen MH, Huang CF, Hsiao M, Chen MH. Identification of MALT1 as both a prognostic factor and a potential therapeutic target of regorafenib in cholangiocarcinoma patients. Oncotarget. 2017 Dec 8;8(69):113444-113459.

Chang PM, Cheng CT, Wu RC, Chung YH, Chiang KC, Yeh TS, Liu CY, Chen MH, Chen MH, Yeh CN. Nab-paclitaxel is effective against intrahepatic cholangiocarcinoma via disruption of desmoplastic stroma. Oncol Lett. 2018 Jul;16(1):566-572

Hung M, Huang DF, Chen WS, Lai CC, Chen MH, Liao HT, Tsai CY. The clinical features and mortality risk factors of cytomegalovirus infection in patients with systemic lupus erythematosus. J Microbiol Immunol Infect. 2019 Feb;52(1):114-121.

Leu CM, Hsu TS, Kuo YP, Lai MZ, Liu PC, Chen MH, Chang DM, Tsai CY, Chen MH*. Deltex1 suppresses T cell function and is a biomarker for diagnosis and disease activity of systemic lupus erythematosus. Rheumatology (Oxford). 2019; 58:719-728. (IF 7.580)

Wang KC, Liao HT, Chen WS, Lai CC, Chou CT, Chen MH*, Tsai CY*. Real-world effectiveness and safety of rituximab in the treatment of rheumatoid arthritis: A single-center experience in Taiwan. Int J Rheum Dis. 2019;22:860-868. 並列通訊作者

Chuang HC, Chen YM, Chen MH, Hung WT, Yang HY, Tseng YH, Tan TH. AhR-ROR-γt complex is a therapeutic target for MAP4K3/GLKhighIL-17Ahigh subpopulation of systemic lupus erythematosus. FASEB J. 2019;33:11469-11480.

Chen MH, Huang MT, Yu WK, Lee SS, Wang JH, Cheng TR, Bowman MR, Hsieh SL. Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients. J Biomed Sci. 2019;26:97. (IF 8.410)

Chen MH, Chen MH, Chou CT, Hou MC, Tsai CY, Huang YH. Low but Long-lasting Risk of Reversal of Seroconversion in Patients With Rheumatoid Arthritis Receiving Immunosuppressive Therapy. Clin Gastroenterol Hepatol. 2020: S1542-3565(20) 30351-7. (IF 11.382)

Liu PC, Ssu CT, Tsao YP, Liou TL, Tsai CY, Chou CT, Chen MH*, Leu CM*. Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) suppresses Staphylococcus aureus-induced CD80, CD86, and pro-inflammatory cytokine expression in human B cells. Arthritis Res Ther. 2020;22(1):64. (IF 5.156) 並列通訊作者

Hsieh SC, Shen CY, Liao HT, Chen MH, Wu CH, Li KJ, Lu CS, Kuo YM, Tsai HC, Tsai CY, Yu CL. The Cellular and Molecular Bases of Allergy, Inflammation and Tissue Fibrosis in Patients with IgG4-related Disease. Int J Mol Sci. 2020;21:5082. (Impact Factor: 5.923)

Li TH, Chang YS, Liu CW, Su CF, Tsai HC, Tsao YP, Liao HT, Chen MH, Chuang CC, Yang YY, Tsai CY. The prevalence and risk factors of sarcopenia in rheumatoid arthritis patients: A systematic review and meta-regression analysis. Semin Arthritis Rheum. 2020;51:236-245. (IF 4.751)

CY Tsai, SC Hsieh, CW Liu, CS Lu, CH Wu, HT Liao, MH Chen, KJ Li, CY Shen, YM Kuo, CL Yu . Cross-Talk among Polymorphonuclear Neutrophils, Immune, and Non-Immune Cells via Released Cytokines, Granule Proteins, Microvesicles, and Neutrophil Extracellular Trap Formation: A Novel Concept of Biology and Pathobiology for Neutrophils. Int J Mol Sci . 2021;22:3119. (Impact Factor: 5.923)

Tsai CY, Hsieh SC, Liu CW, Lu CH, Liao HT, Chen MH, Li KJ, Wu CH, Shen CY, Kuo YM, Yu CL. The Expression of Non-Coding RNAs and Their Target Molecules in Rheumatoid Arthritis: A Molecular Basis for Rheumatoid Pathogenesis and Its Potential Clinical Applications. Int J Mol Sci. 2021 May 26;22(11):5689. (Impact Factor: 5.923)

Chen MH*, Lee IC, Chen MH, Hou MC, Tsai CY, Huang YH*. Abatacept is second to rituximab at risk of HBsAg reverse seroconversion in patients with rheumatic disease. Ann Rheum Dis. 2021 Nov;80(11):1393-1399. (Impact Factor: 19.103) 並列通訊作者

Chuang HC, Chen MH, Chen YM, Ciou YR, Hsueh CH, Tsai CY, Tan TH. ECP Overexpression in T Cells and Exosomes Induces IFN-γ Production and Tissue Inflammation. Arthritis Rheumatol. 2022 Jan;74(1):92-104. (Impact Factor: 10.995)

Tsai HC, Tung HY, Liu CW, Su CF, Sun YS, Chen WS, Chen MH, Lai CC, Liao HT, Yang YY, Huang YH, Tsai CY. Significance of high serum IgG4 in complete or non-full-fledged IgG4-related disease-a retrospective investigation of 845 patients and its clinical relevance. Clin Rheumatol. 2021 Aug 29. doi: 10.1007/s10067-021-05772-x.

Wu SY, Wu CY, Chen MH, Huang HY, Chen YH, Tsao YP, Lai YL, Lee SY. Periodontal conditions in patients with Sjögren's syndrome: A meta-analysis. J Dent Sci. 2021;16:1222-1232

Chen MH, Wu CS, Chen MH, Tsai CY, Lee FY, Huang YH. High Risk of Viral Reactivation in Hepatitis B Patients with Systemic Lupus Erythematosus. Int J Mol Sci. 2021 Aug 24;22(17):9116. (Impact Factor: 5.923)

Huai-Chia Chuang#, Ming-Han Chen#, Yi-Ming Chen, Huang-Yu Yang, Yi-Ru Ciou, Chia-Hsin Hsueh, Ching-Yi Tsai, Tse-Hua Tan. BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus. Theranostics 2021; 11(20):9953-9966. (Impact Factor: 11.556)並列第一作者

Chun-Chun Wang, Kuo-Sen Tseng, Yen-Po Tsao, Wei-Sheng Chen, Chien-Chih Lai, Yi-Syuan Sun, Hsien-Tzung Liao, Ming-Han Chen,*, Chang-Youh Tsai*. Real-world effectiveness and safety of golimumab in rheumatoid arthritis treatment: A two-center study in Taiwan. J Chin Med Assoc. 2021 Dec 7. doi: 10.1097/JCMA.0000000000000673. 並列通訊作者

Chen MH, Yu SF, Chen JF, Chen WS, Liou TL, Chou CT, Hsu CY, Lai HM, Chen YC, Tsai CY, Cheng TT. Different Effects of Biologics on Systemic Bone Loss Protection in Rheumatoid Arthritis: An Interim Analysis of a Three-Year Longitudinal Cohort Study. Front Immunol. 2021 Dec 20;12:783030. (Impact Factor: 7.561)

Shan-Fu Yu, Ming-Han Chen, Jia-Feng Chen, Yu-Wei Wang, Ying-Chou Chen, Chung-Yuan Hsu, Han-Ming Lai, Wen-Chan Chiu, Chi-Hua Ko, Hsiao-Ru He, Tien-Tsai Cheng. Establishment of a Preliminary FRAX® Based Intervention Threshold for Rheumatoid Arthritis Associated Fragility Fracture– A 3-year Longitudinal, Observational, Cohort Study. Ther Adv Chronic Dis . 2022 Feb 25;13:20406223221078089. (Impact Factor: 5.091)並列第一作者