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I-Hui Lee (李怡慧)

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I-Hui Lee(李怡慧)

簡介

學歷
  1. 瑞典卡洛林斯卡學院神經科學研究所博士
  2. 國立陽明大學醫學院醫學士
經歷 現職:
  1. - 迄今 台北榮民總醫院神經內科腦血管科主任
  2. - 迄今 國立陽明大學腦科學研究所教授
  3. - 迄今 台灣腦中風學會理事
  4. - 迄今 台灣神經學會理事
經歷:
  1. - 花蓮玉里榮民醫院內科主治醫師
醫療專長
  1. 腦血管疾病
  2. 腦中風
  3. 頸動脈狹窄
  4. 血管性失智
證照
  1. 中華民國神經科專科醫師

著作

得獎榮譽  Awards and Honors
2021               第17屆亞洲大洋洲神經醫學聯合國際學術會議論文銀獎
                       Poster Silver Award at 17th Asian Oceanian Congress of Neurology
2020               退輔會年度優良醫師獎
                       Annual Physician Award of Taipei Veterans General Hospital
2011–2021     台灣陽明大學醫學院優良教師獎(琉璃獎)
                       Teaching Award at National Yang Ming Chiao Tung University
2019               腦中風學會優秀論文獎
                       Paper award at Annual meeting of Taiwan Stroke Society
2017               腦中風學會日新論文獎
                       Paper award at Annual meeting of Taiwan Stroke Society
2011–2014     台灣神經學會優良壁報獎
                       Poster award at Taiwan Neurological Society meeting
2014               腦血管疾病防治基金會高明見教授優秀論文獎
                       Paper award by Professor Ming-Chien Kao at Taiwan Stroke Association
2013               立夫基金會學術獎佳作
                       Paper award by Li-Fu Medical Research Foundation
2012               台北醫學大學附設阮綜合醫院論文獎第三名
                       Paper award by Taipei Medical University Hospital
2012               榮台聯大學術論文獎第三名
         Paper award by Veterans General Hospitals University System of Taiwan Joint Research Program
2012               台北榮總學術論文獎第三名
                       Paper award by Taipei Veterans General Hospital

 

研究興趣
1.    腦中風疾病的新精準醫療: 家族性中風的遺傳危險因子
2.    經顱大腦刺激術對亞急性中風病人運動網路及上肢恢復的效應
3.    無中風症狀頸動脈嚴重狹窄的輕度認知障礙
4.    成鼠中風後大腦的神經新生及神經發炎機制

 

媒體影音報導

 

學術論文  Selected Publications

  1. Chou CC, Shih YC, Chiu HH, Yu HY, Lee IH, Lin YY, Lee CC, Peng SJ*. Strategic infarct location for post-stroke seizure, NeuroImage: Clinical, 2022;35:103069.
  2. Hsu SP, Lu CF, Lin BF, Tang CW, Kuo IJ, Tsai YN, Kuo CY, Lee PL, Shyu KK, Niddam DM, Lee IH*. Effects of bihemispheric transcranial direct current stimulation on motor recovery in subacute stroke patients: a double-blind, randomized sham-controlled trial, under review.
  3. Chang LH, Chi NF, Chen CY, Lin YS, Hsu SL, Tsai JY, Huang HC, Lin CJ, Chung CP, Tung CY, Jeng CJ, Lee YC, Liu YT*, Lee IH*. Monogenic etiologies for intracerebral hemorrhage and small vessel disease in familial stroke identified by whole exome sequencing across stroke subtypes, under review.
  4. Lin CJ, Chang FC, Lin CJ, Liaw YC, Tu PC, Wang PN, Saver JL, Lee IH*. Long-term Cognitive and Multimodal Imaging Outcomes after Carotid Artery Stenting vs Intensive Medication Alone for Severe Asymptomatic Carotid Stenosis. Journal of the Formosan Medical Association. 2022;121 (1 Pt 1):134-143.
  5. Lee TM, Lee PL*, Lee IH, Lee WK, Wu TY, Hsu HT, Yeh CL, Lin PJ, Shyu KK. Study of heart-rate variability in a video task using Holo-Hilbert spectral analysis, Biomedical Signal Processing and Control, 2022;71:103229.
  6. Chen CY, Lin PT, Wang YH, Syu RW, Hsu SL, Chang LH, Tsai JY, Huang HC, Liu TC, Lin CJ, Tang CW, Hsu LC, Chung CP, Liu HY, Chi NF, Lee IH*. Etiology and risk factors of intracranial hemorrhage and ischemic stroke in young adults, Journal of the Chinese Medical Association, 2021;84(10): 930-936.
  7. Chien C, Lin CJ, Chang FC, Chung CP, Lin CJ, MD, Liu HY, Chi NF, Hsu LC, Tang CW, Wang SJ, Guo WY, Luo CB, Lai YJ*, Lee IH*. Quantitative CT Angiography Predicts Large Artery Occlusion Types and Successful Thrombectomy in Acute Ischemic Stroke, Journal of the Chinese Medical Association, 2021;84(1):61-67.
  8. Wu HM, Lee IH, Luo CB, Chung CP, Lin YY. Clinical-CT mismatch defined NIHSS ≥ 8 and CT-ASPECTS ≥ 9 as a reliable marker of candidacy for intravenous thrombolytic therapy in acute ischemic stroke, PLoS One, 2021;16(4): e0251077.
  9. Yen HH, Chien C, Lee IH, Chen SP, Luo CB, Lin CJ, Chen ST, Yuan WH, Kuo Y, Wu CH, Chang FC. Application of Flat-Panel Volume Computed Tomography to Evaluate Cerebral Hemorrhage After Mechanical Thrombectomy of Acute Embolic Stroke of the Anterior Circulation, Journal of Computer Assisted Tomography, 2021;45(6):919-925.
  10. Li LH, Chen CT, Chang YC, Chen YJ, Lee IH, How CK, MD. Prognostic role of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune inflammation index in acute ischemic stroke, Medicine, 2021;100(25):e26354. 
  11. Kuo IJ, Tang CW, Tsai YA, Tang SC, Lin CJ, Hsu SP, Liang WK, Juan CH, Zich C, Stagg CJ, Lee IH*. Neurophysiological signatures of hand motor response to dual-transcranial direct current stimulation in subacute stroke: a TMS and MEG study, Journal of NeuroEngineering and Rehabilitation, 2020;17(1):72.
  12. Tang CW, Hsiao FJ, Lee PL, Tsai YA, Hsu YF, Chen WT, Lin YY, Stagg CJ, Lee IH*. β-Oscillations Reflect Recovery of the Paretic Upper Limb in Subacute Stroke, Neurorehabilitation and Neural Repair, 2020;34(5):450–462.
  13. Chen CY, Chang FC, Lee IH, Chung CP. Involvement of matrix metalloproteinase 9 in vertebral arterial dissection with posterior circulation ischemic stroke, Journal of the American Heart Association, 2020;9:e016743.
  14. Liu HY, Wu JY, Chung CP, Lee IH, Lin CJ, Lin CJ, Hsu LC, Chao TF. Premature atrial contractions and their association with stroke features and outcome, Journal of Stroke and Cerebrovascular Diseases, 2020;29(10):105118.
  15. Lin CJ, Luo CB, Chien C, Chang FC, Lin CJ, Lee IH, Hsu LC, Chung CP, Liu HY, Chi NF, How CK, Wang SJ, Guo WY, Lin YY. Better endovascular mechanical thrombectomy outcome in atrial fibrillation patients with acute ischemic stroke: A single-center experience, Journal of the Chinese Medical Association, 2020;83(8):756-760.
  16. Tsai LK, Lee IH, Chen YL, Chao TF, Chen YW, Po HL, Lien LM, Chu PH, Huang WC, Lin TH, Lin MT, Jeng JH*, Hwang JJ*. Diagnosis and Treatment for embolic stroke of undetermined source: Consensus statement from the Taiwan stroke society and Taiwan society of cardiology, Journal of the Formosan Medical Association, 2021;120(1 Pt 1):93-106.
  17. Chen WC, Chang LH, Huang SS, Huang YJ, Chih CL, Kuo KC, Lee YH*, Lee IH*. Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brain, Journal of Neuroinflammation, 2019;16(1):187.
  18. Su HH, Wang YH, Chen KM, Lin CW, Lee IH, Li YJ, Huang JY, Tsai SK, Yen JC, Huang SS*. Exogenous GDF11 attenuates non- canonical TGF-β signaling to protect the heart from acute myocardial ischemia– reperfusion injury. Basic Research in Cardiology, 2019;114(3):20.
  19. Huang HC, Tsai JY, Liu TC, Sheng WY, Lin TC, Lin CW, Lee IH, Chung CP. Functional Recovery of Stroke Patients with Post-Acute Care: A Retrospective Study in a Northern Medical Center. J Chin Med Assoc. 2019;82(5):424-427. 
  20. Wang IK, Liu CH, Yen TH, Jeng JS, Sung SF, Huang PH, Li JY, Sun Y, Wei CY, Lien LM, Tsai IJ, Sung FC, Hsu CY; Taiwan Stroke Registry Investigators. Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke. Atherosclerosis 2018;269:288-293.
  21. Chang LH, Lin HC, Huang SS, Chen IC, Chu KW, Chih CL, Liang YW, Lee YC, Chen YY, Lee YH, Lee IH*. Blockade of soluble epoxide hydrolase attenuates post-ischemic neuronal hyperexcitation and confers resilience against stroke with TrkB activation, Scientific Reports 2018;8(1):118.
  22. Hu YS, Guo WY, Lee IH, Chang FC, Lin CJ, Lin CJ, Luo CB, Wu CC, Lee HJ. Prolonged cerebral circulation time is more associated with symptomatic carotid stenosis than stenosis degree or collateral circulation, J NeuroIntervent Surg 2018;10(5):476-480.
  23. Ho CH, Lin WC, Hsu YF, Lee IH, Hung YC. One-Year Risk of Pneumonia and Mortality in Patients with Poststroke Dysphagia: A Nationwide Population-Based Study. J Stroke Cerebrovascular Diseases 2018;27(5):1311-1317.
  24. Lee IH, Huang SS, Chuang CY, Liao KH, Chang LH, Chuang CC, Su YS, Lin HJ, JY Hsieh, Su SH, Lee OK, Kuo HC*. Delayed epidural transplantation of human induced pluripotent stem cell-derived neural progenitors enhances functional recovery after stroke, Scientific Reports 2017;7(1):1943.
  25. Lin CJ, Chang, FC, Chou KH, Tu PC, Lee YH, Lin, CP, Wang, PN, Lee IH*, Intervention versus Aggressive Medical Therapy for Cognition in Severe Asymptomatic Carotid Stenosis. American Journal of Neuroradiology, 2016; Apr 28, Epub ahead of print.
  26. Liu PY, Lee IH, Tan PH, Wang YP, Tsai CF, Lin HC, Lee FY, Lu CL*, P2X7 receptor mediates spinal microglia activation of visceral hyperalgesia in a rat model of chronic pancreatitis, Cellular and Molecular Gastroenterology and Hepatology 2015;1:710-720.e715.
  27. Hsu HT, Lee IH, Tsai HT, Chang HC, Shyu KK, Hsu CC, Chang HH, Yeh TK, Chang CT, Hsu PC, Lee PL*, Evaluate the feasibility of using frontal SSVEP to implement an SSVEP-based BCI in Young, Elderly and ALS groups. Transactions on Neural Systems & Rehabilitation Engineering 2016; 24(5): 603-15.
  28. Liao YC, Hsiao CT, Fuh JL, Chern CM, Lee WJ, Guo YC, Wang SJ, Lee IH, Liu YT, Wang YF, Chang FC, Chang MH, Soong BW, Lee YC, Characterization of CADASIL among the Han Chinese in Taiwan: Distinct Genotypic and Phenotypic Profiles. PLoS One 2015; 10 (8): e0136501.
  29. Lin CJ, Tu PC, Chern CM, Hsiao FJ, Chang FC, Cheng HL, Tang CW, Lee YC, Chen WT, Lee IH*. Connectivity features for identifying cognitive impairment in presymptomatic carotid stenosis. PLoS ONE 2014; 9 (1): e85441.
  30. Hsu YF, Huang YZ, Lin YY, Liao KK, Lee PL, Tsai YA, Yeh CL, Cheng HL, Cheng H, Chern CM, Lee IH*. Intermittent theta burst stimulation over ipsilesional primary motor cortex of subacute ischemic stroke patients: a pilot study. Brain Stimulation 2013;6(2):166-174.
  31. Huang SS, Cheng H, Tang CM, Nien MW, Huang YS, Lee IH, Yin JH, Kuo TBJ, Yang CCH, Hung YC, Tsai SK*, Yang DI*. Anti-oxidative, anti-apoptotic, and pro-angiogenic effects mediate functional improvement by sonic hedgehog against focal cerebral ischemia in rats. Experimental Neurology, 2013;247:680-88.
  32. Hsieh JY, Wang HW, Chang SJ, Liao KH, Lee IH, Lin WS, Wu CH, Lin WY, Cheng SM. Mesenchymal stem cells from human umbilical cord express preferentially secreted factors related to neuroprotection, neurogenesis, and angiogenesis. PLoS One. 2013;22(8):e72604.
  33. Soong BW, Liao YC, Tu PH, Tsai PC, Lee IH, Chung CP, Lee YC. A homozygous NOTCH3 mutation p.R544C and a heterozygous TREX1 variant p.C99MfsX3 in a family with hereditary small vessel disease of the brain. Journal of the Chinese Medical Association 2013;76:319e324.
  34. Cheng HL, Lin CJ, Soong BW, Wang PN, Chang FC, Wu YT, Chou KH, Lin CP, Tu PC*, Lee IH*. Impairments in cognitive function and brain connectivity in severe asymptomatic carotid stenosis. Stroke, 2012;43(10):2567-73.
  35. Hsu WY, Cheng CH, Liao KK, Lee IH, Lin YY. Effects of repetitive transcranial magnetic stimulation on motor functions in stroke patients: a meta-analysis. Stroke, 2012;43(7):1849-57.
  36. Liu PY, Lu CL, Wang CC, Lee IH, Lee HF, Luo JC, Lin HC, Chang FY, Lee SD. Spinal Microglia Mediate the Maintenance and Initiation of Hyperalgesia in Chronic Pancreatitis. Gastroenterology, 2012;142(1):165-73.
  37. Chang HC, Lee PL, Lo MT, Lee IH, Yeh TK, Chang CY. Independence of amplitude-frequency and phase calibrations in an SSVEP-Based BCI using stepping delay flickering sequences. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2012;20(3):305-12.
  38. Tsai CP, Soong BW, Tu PH, Lin KP, Fuh JL, Tsai PC, Lu YC, Lee IH, Lee YC*. A hexanucleotide repeat expansion in C9ORF72 causes familial and sporadic ALS in Taiwan. Neurobiology of Aging, 2012; 33(9):2232.e11-8.
  39. Hsu YF, Liao KK, Lee PL, Tsai YA, Yeh CL, Lai KL, Huang YZ, Lin YY, Lee IH*. Intermittent theta burst stimulation over primary motor cortex enhances movement- related beta synchronization. Clinical Neurophysiology, 2011; 122(11): 2260-7.
  40. Tang CW, Chang FC, Chern CM, Lee YC, Hu HH, Lee IH*. Stenting versus medical treatments for severe symptomatic intracranial stenosis. American Journal of Neuroradiology, 2011; 32(5): 911-6.
  41. Lee YC, Liao YC, Wang PS, Lee IH, Lin, KP, Soong BW. Comparison of Cerebellar Ataxias: a Three-Year Prospective Longitudinal Assessment. Movement Disorders, 2011; 26(11): 2081-7.
  42. Lin KP, Soong BW, Yang CC, Huang LW, Chang MH, Lee IH, Antonellis A, Lee YC. The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan. PLoS ONE, 2011; 6(12): e29393.
  43. Huang MC, Chang PT, Tsai MJ, Kuo HS, Kuo WC, Lee MJ, Lo MJ, Lee IH, Huang WC, Lee LM, Shih YH, Lee LS, Cheng H. Sensory and motor recovery after repairing transected cervical roots. Surgical Neurology 2007 Nov; 68, S17-S24.
  44. Johansson S*, Lee IH, Olson L, Spenger C. Olfactory ensheathing glial co-grafts improve functional recovery in 6-OHDA lesioned rats. Brain, 2005; 128 (12), 2961-2976.
  45. Lee IH*, Lindqvist E, Kiehn O, Widenfalk J, Olson L. Glial and neuronal connexin expression patterns in the rat spinal cord during development and following injury. Journal of Comparative Neurology 2005 Aug; 489 (1): 1-10.
  46. Lee IH*, Bulte JWM, Schweinhardt P, Douglas T, Trifunovski A, Hofstetter C, Olson L, Spenger C. In vivo magnetic resonance tracking of olfactory ensheathing glia grafted into the rat spinal cord. Experimental Neurology 2004 Jun; 187(2): 509-516.
  47. Lee LM, Huang MC, Chuang TY, Lee LS, Cheng H, Lee IH*. Acidic FGF enhances functional regeneration of adult dorsal roots. Life Sciences 2004 Feb; 74 (15): 1937-1943.
  48. Lee IH, Lu YC, Chang YC, Soong BW*. Dentatorubral-Pallidoluysian atrophy among the Chinese. Archives of Neurology 2001 Nov; 58(11):1905-1908
  49. Lee IH*, Kwan SY, Su MS. Eating seizures in Lennox-Gastaut syndrome. European Neurology 2001;45(2):123-125.