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杜培基 (Pei-Chi Tu)

杜培基(Pei-Chi Tu)圖 掛號

[簡介]

  • 學歷
    • 國立陽明大學認知神經科學博士
    • 國立中正大學哲學碩士
    • 國立陽明大學認知神經科學博士
  • 經歷
    現職：
    • - 迄今 臺北榮民總醫院精神部主治醫師
    • - 迄今 臺北榮民總醫院精神部教學主任
    • - 迄今 國立陽明交通大學醫學系 部定教授
    經歷：
    • - 美國麻省總醫院精神影像部博士後研究員
    • - 台北市立關渡醫院主治醫師
    • - 臺中榮民總醫院灣橋分院 主治醫師
    • - 臺北榮民總醫院精神部住院醫師及總醫師
  • 醫療專長
    1. 思覺失調症
    2. 憂鬱症
    3. 躁鬱症
    4. 焦慮症
    5. 成人一般身心失眠
    6. 精神疾病腦造影
  • 證照
    臺灣精神科專科醫師 臺灣生物精神醫學暨神經精神藥理學學會 會員 臺灣精神醫學會 會員

[著作]

  1. Chen, M. H., Chang, W. C., Lin, W. C., Tu, P. C., Li, C. T., Bai, Y. M., Tsai, S. J., Huang, W. S., & Su, T. P. Functional dysconnectivity of frontal cortex to striatum predicts ketamine infusion response in treatment-resistant depression. INT J NEUROPSYCHOPH. 2020; [epub ahead of print].
  2. Chen, M. H., Hsu, J. W., Huang, K. L., Tsai, S. J., Su, T. P., Li, C. T., Lin, W. C., Tu, P. C., & Bai, Y. M. Role of obesity in systemic low-grade inflammation and cognitive function in patients with bipolar I disorder or major depressive disorder. CNS spectrums. 2020; 1-7 [epub ahead of print].
  3. Chen, M. H., Kao, Z. K., Chang, W. C., Tu, P. C., Hsu, J. W., Huang, K. L., Su, T. P., Li, C. T., Lin, W. C., Tsai, S. J., & Bai, Y. M. Increased Proinflammatory Cytokines, Executive Dysfunction, and Reduced Gray Matter Volumes in First-Episode Bipolar Disorder and Major Depressive Disorder. J Affect Disord. 2020; 274, 825–831.
  4. Chen, M. H., Lin, W. C., Tu, P. C., Li, C. T., Bai, Y. M., Tsai, S. J., & Su, T. P. Antidepressant and antisuicidal effects of ketamine on the functional connectivity of prefrontal cortex-related circuits in treatment-resistant depression: A double-blind, placebo-controlled, randomized, longitudinal resting fMRI study. J Affect Disord. 2020; 259:15-20.
  5. Chen, M. H., Lin, W. C., Wu, H. J., Bai, Y. M., Li, C. T., Tsai, S. J., Hong, C. J., Tu, P. C., Cheng, C. M., & Su, T. P. Efficacy of low-dose ketamine infusion in anxious vs non-anxious depression: revisiting the Adjunctive Ketamine Study of Taiwanese Patients with Treatment-Resistant Depression. CNS spectrums. 2020; 1-6 [epub ahead of print].
  6. Bai YM, Chen MH, Hsu JW, Huang KL, Tu PC, Chang WC, Su TP, Li CT, Lin WC, Tsai SJ. A comparison study of metabolic profiles, immunity, and brain gray matter volumes between patients with bipolar disorder and depressive disorder. J Neuroinflammation. 2020; 17(1):42.
  7. Chen MH, Chen YL, Bai YM, Huang KL, Wu HJ, Hsu JW, Su TP, Tsai SJ, Tu PC, Li CT, Lin WC, Wu YT. Functional connectivity of specific brain networks related to social and communication dysfunction in adolescents with attention-deficit hyperactivity disorder. Psychiatry Res. 2020; 284:112785.
  8. Li CT, Cheng CM, Chen MH, Juan CH, Tu PC, Bai YM, Jeng JS, Lin WC, Tsai SJ, Su TP. Antidepressant Efficacy of Prolonged Intermittent Theta Burst Stimulation Monotherapy for Recurrent Depression and Comparison of Methods for Coil Positioning: A Randomized, Double-Blind, Sham-Controlled Study. Biol Psychiatry. 2020; 87(5):443-450.
  9. PC Tu, TP Su, WC Lin, WC Chang, YM Bai, CT Li, FH Lin. Reduced synchronized brain activity in schizophrenia during viewing of comedy movies. Scientific reports. 2019; 9(1):12738.
  10. Tu, P. C., Bai, Y. M., Li, C. T., Chen, M. H., Lin, W. C., Chang, W. C., & Su, T. P. Identification of Common Thalamocortical Dysconnectivity in Four Major Psychiatric Disorders. Schizophr Bull. 2019; 45(5):1143-1151.
  11. Chen MH, Chang WC, Bai YM, Huang KL, Tu PC, Su TP et al. Cortico-thalamic dysconnection in early-stage schizophrenia: a functional connectivity magnetic resonance imaging study. European archives of psychiatry and clinical neuroscience 2019; 245:8-15.
  12. Chen, M. H., Chang, W. C., Hsu, J. W., Huang, K. L., Tu, P. C.*, Su, T. P., . . . Bai, Y. M. Correlation of proinflammatory cytokines levels and reduced gray matter volumes between patients with bipolar disorder and unipolar depression. J Affect Disord, 2018; 245, 8-15. doi: 10.1016/j.jad.2018.10.106
  13. Chen, M. H., Li, C. T., Lin, W. C., Hong, C. J., Tu, P. C., Bai, Y. M., . . . Su, T. P. Persistent antidepressant effect of low-dose ketamine and activation in the supplementary motor area and anterior cingulate cortex in treatment-resistant depression: A randomized control study. J Affect Disord, 2018; 225, 709-714. doi: 10.1016/j.jad.2017.09.008
  14. Tu, P. C., Kuan, Y.H., Li, C.T., Su, T. P. Structural Correlates of Trait Impulsivity in Patients with Bipolar Disorder and Healthy Controls - A Surface-Based Morphometry Study. Psychological medicine. 2017; 47(7):1292-1299.
  15. Tu PC, Li CT, Lin WC, Chen MH, Su TP, Bai YM. Structural and functional correlates of serum soluble IL-6 receptor level in patients with bipolar disorder. Journal of affective disorders. 2017; 219:172-7.
  16. Tu PC, Kuan YH, Li CT, Su TP. Structural correlates of creative thinking in patients with bipolar disorder and healthy controls-a voxel-based morphometry study. Journal of affective disorders. 2017; 215:218-24.
  17. Su TP, Chen MH, Li CT, Lin WC, Hong CJ, Gueorguieva R, Tu PC, Bai YM, Cheng CM, Krystal JH. Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression. Neuropsychopharmacology. 2017;43(13): 2482-2492.
  18. Lin, C.-J., Chang, F.-C., Chou, K.-H., Tu, P.-C., Lee, Y.-H., Lin, C.-P., Wang, P.-N., Lee, I.-H. Intervention versus Aggressive Medical Therapy for Cognition in Severe Asymptomatic Carotid Stenosis. American Journal of Neuroradiology. 2016; 37: 1889-1897.
  19. Li CT, Hsieh JC, Huang HH, Chen MH, Juan CH, Tu PC, Lee YC, Wang SJ, Cheng CM, Su TP. Cognition-Modulated Frontal Activity in Prediction and Augmentation of Antidepressant Efficacy: A Randomized Controlled Pilot Study. Cerebral Cortex. 2016; 26(1):202-10.
  20. Li CT, Chen MH, Lin WC, Hong CJ, Yang BH, Liu RS, Tu PC, Su TP. The effects of low-dose ketamine on the prefrontal cortex and amygdala in treatment-resistant depression: A randomized controlled study. Human Brain Mapping. 2016; 37(3):1080-90.
  21. Bai, Y.M., Li, C.T., Tsai, S.J., Tu, P.C., Chen, M.H., Su, T.P. Metabolic syndrome and adverse clinical outcomes in patients with bipolar disorder. BMC psychiatry. 2016; 16(1): 488.
  22. Tu, P. C., Hsu, J. W., Lan, C. C., Liu, C. C., Su, T. P., & Chen, Y. S. (2016). Structural and functional correlates of a quantitative autistic trait measured using the social responsive scale in neurotypical male adolescents. Autism Res 9(5):570-8. doi: 10.1002/aur.1535 (SCI)
  23. Tu, P.-C., Lee, Y.-C., Chen, Y.-S., Hsu, J.-W., Li, C.-T., Su, T.-P., 2015. Network-specific cortico-thalamic dysconnection in schizophrenia revealed by intrinsic functional connectivity analyses. Schizophr Res 166, 137-143. (SCI)
  24. Bai, Y.M., Su, T.P., Li, C.T., Tsai, S.J., Chen, M.H., Tu, P.C., Chiou, W.F., 2015. Comparison of pro-inflammatory cytokines among patients with bipolar disorder and unipolar depression and normal controls. Bipolar Disord 17, 269-277. (SCI)
  25. Tu, P.C., Su, T.P., Huang, C.C., Yang, A.C., Yeh, H.L., Hong, C.J., Liou, Y.J., Liu, M.E., Lin, C.P., Tsai, S.J., 2014. Interleukin-1 beta C-511T polymorphism modulates functional connectivity of anterior midcingulate cortex in non-demented elderly Han males. Brain Struct Funct 219, 61-69. (SCI)
  26. Bai, Y.M., Su, T.P., Tsai, S.J., Wen-Fei, C., Li, C.T., Pei-Chi, Tu., Mu-Hong, C., 2014. Comparison of inflammatory cytokine levels among type I/type II and manic/hypomanic/euthymic/depressive states of bipolar disorder. J Affect Disord 166, 187-192. (SCI)
  27. Li, C.T., Bai, Y.M., Hsieh, J.C., Lee, H.C., Yang, B.H., Chen, M.H., Lin, W.C., Tsai, C.F., Tu, P.C., Wang, S.J., Su, T.P., 2015a. Peripheral and central glucose utilizations modulated by mitochondrial DNA 10398A in bipolar disorder. Psychoneuroendocrinology 55, 72-80. (SCI)
  28. Li, C.T., Su, T.P., Wang, S.J., Tu, P.C., Hsieh, J.C., 2015b. Prefrontal glucose metabolism in medication-resistant major depression. Br J Psychiatry 206, 316-323. (SCI)
  29. Li, C.-T., Hsieh, J.-C., Huang, H.-H., Chen, M.-H., Juan, C.-H., Tu, P.-C., Lee, Y.-C., Wang, S.-J., Cheng, C.-M., Su, T.-P., 2014a. Cognition-Modulated Frontal Activity in Prediction and Augmentation of Antidepressant Efficacy: A Randomized Controlled Pilot Study. Cerebral Cortex. (SCI)
  30. Li, C.T., Bai, Y.M., Lee, Y.C., Mao, W.C., Chen, M.H., Tu, P.C., Chen, Y.S., Chen, T.J., Chang, W.H., Su, T.P., 2014b. High dosage of hypnotics predicts subsequent sleep-related breathing disorders and is associated with worse outcomes for depression. Sleep 37, 803-809, 809a-809b. (SCI)
  31. Li, C.T., Chen, M.H., Juan, C.H., Huang, H.H., Chen, L.F., Hsieh, J.C., Tu, P.C., Bai, Y.M., Tsai, S.J., Lee, Y.C., Su, T.P., 2014c. Efficacy of prefrontal theta-burst stimulation in refractory depression: a randomized sham-controlled study. Brain 137, 2088-2098. (SCI)
  32. Li, C.T., Hsieh, J.C., Huang, H.H., Chen, M.H., Juan, C.H., Tu, P.C., Lee, Y.C., Wang, S.J., Cheng, C.M., Su, T.P., 2014d. Cognition-Modulated Frontal Activity in Prediction and Augmentation of Antidepressant Efficacy: A Randomized Controlled Pilot Study. Cereb Cortex. (SCI)
  33. Chen, Y.L., Tu, P.C., Lee, Y.C., Chen, Y.S., Li, C.T., Su, T.P., 2013. Resting-state fMRI mapping of cerebellar functional dysconnections involving multiple large-scale networks in patients with schizophrenia. Schizophr Res 149, 26-34. (SCI)
  34. Ku, H.L., Lin, C.S., Chao, H.T., Tu, P.C., Li, C.T., Cheng, C.M., Su, T.P., Lee, Y.C., Hsieh, J.C., 2013. Brain signature characterizing the body-brain-mind axis of transsexuals. PLoS One 8, e70808. (SCI)
  35. Li, C.T., Bai, Y.M., Tu, P.C., Lee, Y.C., Huang, Y.L., Chen, T.J., Chang, W.H., Su, T.P., 2012. Major depressive disorder and stroke risks: a 9-year follow-up population-based, matched cohort study. PLoS One 7, e46818. (SCI)
  36. Tu, P.C., Lee, Y.C., Chen, Y.S., Li, C.T., Su, T.P., 2013. Schizophrenia and the brain's control network: aberrant within- and between-network connectivity of the frontoparietal network in schizophrenia. Schizophr Res 147, 339-347. (SCI)
  37. Li, C.T., Chen, L.F., Tu, P.C., Wang, S.J., Chen, M.H., Su, T.P., Hsieh, J.C., 2013. Impaired prefronto-thalamic functional connectivity as a key feature of treatment-resistant depression: a combined MEG, PET and rTMS study. PLoS One 8, e70089. (SCI)
  38. Lin, C.J., Tu, P.C., Chern, C.M., Hsiao, F.J., Chang, F.C., Cheng, H.L., Tang, C.W., Lee, Y.C., Chen, W.T., Lee, I.H., 2014a. Connectivity features for identifying cognitive impairment in presymptomatic carotid stenosis. PLoS One 9, e85441. (SCI)
  39. Lin, C.S., Ku, H.L., Chao, H.T., Tu, P.C., Li, C.T., Cheng, C.M., Su, T.P., Lee, Y.C., Hsieh, J.C., 2014b. Neural network of body representation differs between transsexuals and cissexuals. PLoS One 9, e85914. (SCI)
  40. Yang, A.C., Huang, C.C., Yeh, H.L., Liu, M.E., Hong, C.J., Tu, P.C., Chen, J.F., Huang, N.E., Peng, C.K., Lin, C.P., Tsai, S.J., 2013. Complexity of spontaneous BOLD activity in default mode network is correlated with cognitive function in normal male elderly: a multiscale entropy analysis. Neurobiol Aging 34, 428-438.
  41. Liu, M.E., Huang, C.C., Chen, M.H., Yang, A.C., Tu, P.C., Yeh, H.L., Hong, C.J., Chen, J.F., Hwang, J.P., Lin, C.P., Tsai, S.J., 2014a. Effect of the BDNF Val66Met polymorphism on regional gray matter volumes and cognitive function in the Chinese population. Neuromolecular Med 16, 127-136. (SCI)
  42. Liu, M.E., Huang, C.C., Hwang, J.P., Yang, A.C., Tu, P.C., Yeh, H.L., Hong, C.J., Liou, Y.J., Chen, J.F., Lin, C.P., Tsai, S.J., 2013a. Effect of Bcl-2 rs956572 SNP on regional gray matter volumes and cognitive function in elderly males without dementia. Age (Dordr) 35, 343-352. (SCI)
  43. Liu, M.E., Huang, C.C., Yang, A.C., Tu, P.C., Yeh, H.L., Hong, C.J., Chen, J.F., Liou, Y.J., Lin, C.P., Tsai, S.J., 2013b. Effect of Bcl-2 rs956572 polymorphism on age-related gray matter volume changes. PLoS One 8, e56663. (SCI)
  44. Liu, M.E., Huang, C.C., Yang, A.C., Tu, P.C., Yeh, H.L., Hong, C.J., Liou, Y.J., Chen, J.F., Chou, K.H., Lin, C.P., Tsai, S.J., 2014b. Catechol-O-methyltransferase Val158Met polymorphism on the relationship between white matter hyperintensity and cognition in healthy people. PLoS One 9, e88749. (SCI)
  45. Liu, T.Y., Hsieh, J.C., Chen, Y.S., Tu, P.C., Su, T.P., Chen, L.F., 2012. Different patterns of abnormal gamma oscillatory activity in unipolar and bipolar disorder patients during an implicit emotion task. Neuropsychologia 50, 1514-1520. (SCI)
  46. Teng, S., Lu, C.F., Wang, P.S., Hung, C.I., Li, C.T., Tu, P.C., Su, T.P., Wu, Y.T., 2013. Classification of bipolar disorder using basal-ganglia-related functional connectivity in the resting state. Conf Proc IEEE Eng Med Biol Soc 2013, 1057-1060. (SCI)
  47. Tu, P.C., Chen, L.F., Hsieh, J.C., Bai, Y.M., Li, C.T., Su, T.P., 2012a. Regional cortical thinning in patients with major depressive disorder: a surface-based morphometry study. Psychiatry Res 202, 206-213. (SCI)
  48. Cheng, H.L., Lin, C.J., Soong, B.W., Wang, P.N., Chang, F.C., Wu, Y.T., Chou, K.H., Lin, C.P., Tu, P.C.*, Lee, I.H., 2012. Impairments in cognitive function and brain connectivity in severe asymptomatic carotid stenosis. Stroke 43, 2567-2573. (SCI)
  49. Tu, P.C., Hsieh, J.C., Li, C.T., Bai, Y.M., Su, T.P., 2012. Cortico-striatal disconnection within the cingulo-opercular network in schizophrenia revealed by intrinsic functional connectivity analysis: A resting fMRI study. Neuroimage 59, 238-247.(SCI)
  50. Tu PC, Hsieh JC, Chen LF, Li CT, Bai YM, Su TP. Regional cortical thinning in patients with major depressive disorder: a surface-based morphometry study. Psychiatry Research, NeuroImaging(SCI)
  51. Tu P, R. L. Buckner , L. Zollei, K. A. Dyckman,  D. C. Goff, D. S. Manoach. 2010 Feb;  Reduced functional connectivity in a right-hemisphere network for spatial attention and volitional ocular motor control in schizophrenia. Brain. 133 :625-37. (SCI)
  52. Kong J, Tu PC*, Z. Carolyn,  Su TP. 2010 Aug Intrinsic functional connectivity of the periaqueductal gray, a resting fMRI study. Behav Brain Res. 25;211(2):215-9. 27 *co- first author( SCI)
  53. Krienen FM, Tu PC, Buckner RL. 2010 Oct. Clan mentality: evidence that the medial prefrontal cortex responds to close others. J Neurosci. 13;30(41):13906-15.(SCI)
  54. Chen SS, Tu PC, Su TP, Hsieh JC, Lin YC, Chen LF. 2008 Nov. Impaired frontal synchronization of spontaneous magnetoencephalographic activity in patients with bipolar disorder. Neurosci Lett. 14;445(2):174-8.(SCI)
  55. Tu PC, Yang TH, Kuo WJ, Hsieh JC Su TP. Neural correlates of antisaccade deficits in schizophrenia, an fMRI study. J Psychiatr Res .2006 Oct; 40(7):606-12.  (SCI)      
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