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陳志強 (Chih-Chiang chen)


  • 學歷
    • 陽明大學臨床醫學研究所博士班畢業
    • 陽明大學醫學系畢業
  • 經歷
    • - 迄今 國立陽明大學皮膚學科副教授
    • - 迄今 臺北榮民總醫院皮膚部 部主任
    • - 迄今 臺灣皮膚科醫學會 理事
    • - 迄今 臺灣皮膚科技教育學會 醫學常務理事
    • - 迄今 台灣檢驗及品保學會 理事
    • - 臺北榮總皮膚科專科醫師
    • - 桃園榮民總醫院 皮膚科主治醫師
    • - 美國南加州大學組織工程實驗室進修
    • - 臺北榮總皮膚部 皮膚診斷科 主任
    • - 美國史丹佛大學表徵基因 實驗室進修
  • 醫療專長
    1. 落髮、青春痘、異位性皮膚炎、蕁麻疹、醫學美容、乾癬
  • 證照





  1. Li CL, Chen CC*. Progressive hair loss with short hair in a child. JAMA Dermatol. 2022 Nov 23. (I.F. 11.8, Ranking: 2/68)
  2. Wang YC, Lin YH, Ma SH, MD, Chang YT, Chen CC*. Infection risk in psoriatic patients receiving tumour necrosis factor inhibitors: a 20-year systematic review and meta-analysis of randomized controlled trials. J Eur Acad Dermatol Venereol. 2022 Jul 6. doi: 10.1111. (I.F. 9.228, Ranking: 4/68)
  3. Lin CW, Chen CC, Huang WY, Chen YY, Chen ST, Chou HW, Hung CM, Chen WJ,  Lu CS, Nian SX,  Chen SG, Chang HW, Chang Vincet HS, Liu LY, Kuo ML, Chang SC. Restoring Pro-healing/remodeling- associated M2a/c Macrophages using ON101 Accelerates Diabetic Wound Healing. JID Innov 2022 Jun 2;2(5):100138. (Co-first author)
  4. Ma SH, Wei YH, Lee DD, Chang YT, Chen CC*. Efficacy and safety of PavéDerm J-Fill for nasolabial folds: A phase III randomized, blinded, prospective, and split-faced head-to-head trial. Dermatol Ther 2022 Jun 1;e15612. (I.F. 3.858, Ranking: 19/69)
  5. Harn HI, Chen CC, Wang SP, Lei M, Chuong CM. Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging. Front Cell Dev Biol. 2021;9:635340. (I.F. 6.081, Ranking: 6/39)
  6. Ma SH, Sytwu HP, Chen CC*. The cutaneous manifestations related to COVID-19 infection and vaccination: current aspects and future prospects. Dermatol Sin 2021;39:65-6. (I.F. 1.107, Ranking: 63/68)
  7. Dai YX, Chen CC, Tai YH, Chang YT, Chen TJ, Chen MH. Increased Risk of Major Depressive Disorder Among Probands With Psoriasis and Unaffected Siblings: A Nationwide Population-Based Study. J Eur Acad Dermatol Venereol. 2020;34(7):1510-1515. (Co-first author) (I.F. 9.228, Ranking: 4/68)
  8. Dai YX, Tai YH, Chen CC, Chang YT, Chen TJ, Chen MH. Bidirectional association between alopecia areata and major depressive disorder among probands and unaffected siblings: A nationwide population-based study. J Am Acad Dermatol. 2020;82(5):1131-1137. (I.F. 15.487, Ranking: 1/68)
  9. Dai YX, Chuang YY, Chen PY, Chen CC*. Efficacy and Safety of Ablative Resurfacing With A High-Energy 1,064 Nd-YAG Picosecond-domain Laser for the Treatment of Facial Acne Scars in Asians. Lasers Surg Med. 2020 Jun;52(5):389-395. (I.F. 4.025, Ranking: 44/211)
  10. Dai YX, Yeh CP, Chen CC*. Efficacy and safety of tofacitinib therapy in Asian patients with severe alopecia areata. Dermatol Sin 2020;38:3-8. (I.F. 1.107, Ranking: 63/68)
  11. Ma SH, Tai YH, Dai YX, Chen CC, Chen TJ, Chang YT. Impact of the COVID-19 pandemic on dermatology clinic visits: Experience from a tertiary medical center in Taiwan. Dermatol Sin 2020;38:180-1. (I.F. 1.107, Ranking: 63/68)
  12. Chu SY, Chou CH, Huang HD, Yen MH, Hong HC, Chao PH, Wang YH, Chen PU, Nian SX, Chen YR, Liou LY, Liu YC, Chen HM, Lin FM, Chang YT, Chen CC*, Lee OK. Mechanical stretch induces hair regeneration through the alternative activation of macrophages. Nat Commun 2019 Apr 3;10(1):1524 (I.F. 17.694, Ranking: 6/73)
  13. Dai YX, Chen CC*. Tofacitinib therapy for Asian children with severe alopecia areata. J Am Acad Dermatol 2019;80(4):1164-1166. (I.F. 15.487, Ranking: 1/68)
  14. Chen CC, Chang YT, Liu HN, Chen YJ. Cancer risk in patients with alopecia areata: a nationwide population-based matched cohort study. Cancer Med. 2018 Mar 25. (I.F. 4.711, Ranking: 106/245)
  15. Hsu YJ, Chen CC, Huang CH, Yeh CH, Liu LY, Chen SY. Line-scanning hyperspectral imaging based on structured illumination optical sectioning. Biomed Opt Express. 2017;18;8(6):3005-3016. (I.F. 3.562, 31/101)
  16. Chen CC, Plikus MV, Tang PC, Randall B. Widelitz RB, Chuong CM. The modulatable stem cell niche: Tissue interactions during hair and feather follicle regeneration. J Mol Biol 2016;428(7):1423-40.  (I.F. 6.151, Ranking: 71/296)
  17. Chen CC, Wang L, Plikus MV, Jiang TX, Murray PJ, Ramos R, Guerrero-Juarez CF, Hughes MW, Lee OK, Shi S, Widelitz RB, Lander AD, Chuong CM. Organ-level quorum sensing directs regeneration in hair stem cell populations. Cell 2015;161(2):277-290. (I.F. 66.850, Ranking: 2/296)
  18. Hsu MC, Chen CC*. Low-dose methotrexate-induced ulcerated psoriatic plaques : a rare case report. J Am Acad Dermatol 2015;1(5):264-6. (I.F. 15.487, Ranking: 1/68)
  19. Wu LC, Hwang CY, Chung PI, Hua TC, Chen YD, Chu SY, Lee DD, Chang YT, Wang WJ, Liu HN, Chen CC*. Autoimmune Disease Comorbidities in Patients with Atopic Dermatitis: A Nationwide Case-Control Study in Taiwan. Pediatr Allergy Immunol 2014;25(6):586-92. (I.F. 6.377, Ranking: 5/129)
  20. Chen CC, Murray PJ, Jiang TX, Plikus MV, Chang YT, Lee OK, Widelitz RB, Chuong CM. Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4. J Invest Dermatol 2014; 134(8): 2086-96. (I.F. 7.590, Ranking: 5/68)
  21. Chen CC, Chiang AN, Liu HN, Chang YT. EGb-761 prevents ultraviolet B-induced photoaging via inactivation of mitogen-activated protein kinases and proinflammatory cytokine expression. J Dermatol Sci 2014;75(1):55-62. (I.F. 5.408, Ranking: 9/68)
  22. Liu HN, Wang WJ, Chen CC, Lee DD, Chang YT. Senile gluteal dermatosis: a clinical study of 137 cases. Int J Dermatol 2014;53(1):51-5. (I.F. 3.204, Ranking: 27/68)
  23. Shiao YM, Chung HJ, Chen CC, Chiang KN, Chang YT, Lee DD, Lin MW, Tsai SF, Matsuura I. MCP-1 as an Effector of IL-31 Signaling in Familial Primary Cutaneous Amyloidosis. J Invest Dermatol 2013;133(5):1375-8. (I.F. 7.590, Ranking: 5/68)
  24. Chen YJ, Chen CC, Lin MW, Chen TJ, Li CY, Hwang CY, Chu SY, Lee DD, Chang YT, Wang WJ, Liu HN. Increased Risk of Sexual Dysfunction in Male Patients with Psoriasis: A Nationwide Population-Based Follow-Up Study. J Sex Med. 2013;10(5):1212-8. (I.F. 3.937, Ranking: 30/90)
  25. Chueh SC, Lin SJ, Chen CC, Lei M, Wang LM, Widelitz R, Hughes MW, Jiang TX, Chuong CM. Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering. Expert Opin Biol Ther 2013;13(3):377-91. (I.F. 5.589, Ranking: 36/158)
  26. Hwang CY, Hwang YY, Chen YJ, Chen CC, Lin MW, Chen TJ, Lee DD, Chang YT, Wang WJ, Liu HN. Atopic Diathesis in Patients with Kawasaki Disease. J Pediatr 2013;163(3):811-5.
  27. Chu SY, Chen YJ, Liu CJ, Tseng WC, Lin MW, Hwang CY, Chen CC, Lee DD, Chen TJ, Chang YT, Wang WJ, Liu HN. Increased risk of acute myocardial infarction in systemic sclerosis: a nationwide population-based study. Am J Med 2013;126(11):982-8.
  28. Chen CC* and Chuong CM. Multi-layered environmental regulation on the homeostasis of stem cells: The saga of hair growth and alopecia. J Dermatol Sci 2012;66(1):3-11. (I.F. 5.408, Ranking: 9/68)
  29. Li WH, Chen YJ, Tseng WC, Lin MW, Chen TJ, Chu SY, Hwang CY, Chen CC, Lee DD, Chang YT, Wang WJ, Liu HN. Malignancies after renal transplantation in Taiwan: a nationwide population-based study. Nephrol Dial Transplant 2012;27(2):833-9.
  30. Hwang CY, Chen YJ, Lin MW, Chen TJ, Chu SY, Chen CC, Lee DD, Chang YT, Wang WJ, Liu HN. Cancer risk in allergic rhinitis, asthma, and atopic dermatitis: A nationwide cohort study in Taiwan. Int J Cancer 2012; 130(5):1160-7.
  31. Plikus MV, Baker RE, Chen CC, Fare C, de la Cruz D, Andl T, Maini PK, Millar SE, Widelitz R, Chuong CM. Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science 2011;332(6029):586-9. (I.F. 63.798, Ranking: 2/73)
  32. Chen YJ, Wu CY, Lin MW, Chen TJ, Liao KK, Chen YC, Hwang CY, Chu SY, Chen CC, Lee DD, Chang YT, Wang WJ, Liu HN. Comorbidity profiles among patients with bullous pemphigoid: a nationwide population-based study. Br J Dermatol 2011;165(3):593-599.
  33. HN Liu, WJ Wang, CC Chen, DD Lee, YT Chang. Senile gluteal dermatosis - a clinicopathologic study of 12 cases and its distinction from anosacral amyloidosis. J Eur Acad Dermatol Venereol 2011;26(2):258-60.
  34. Szu-Ying Chu, Yi-Ju Chen, Wei-Cheng Tseng, Ming-Wei Lin, Tzeng-Ji Chen, Chian-Yaw Hwang, Chih-Chiang Chen, Ding-Dar Lee, Yun-Ting Chang, Wen-Jen Wang, Han-Nan Liu. Comorbidity profiles among patients with alopecia areata: the importance of onset age, a nationwide population-based study. J Am Acad Dermatol 2011;65(5):949-56.
  35. Han-Nan Liu, Tsung-Yun Liu, Chih-Chiang Chen, Ding-Dar Lee and Yun-Ting Chang. Insights into the mechanism of Piper betle leaf-induced contact leukomelanosis using C57BL/6 mice as the animal model and tyrosinase assays. Australas J Dermatol 2011;52(3):172-8.
  36. Chian-Yaw Hwang, Yi-Ju Chen, Ming-Wei Lin, Tzeng-Ji Chen, Szu-Ying Chu, Chih-Chiang Chen, Ding-Dar Lee, Yun-Ting Chang, Wen-Jen Wan, Han-Nan Liu. Elevated risk of second primary cancer in patients with cutaneous malignant melanoma: a nationwide cohort study in Taiwan. J Dermatol Sci 2010;60(3):167-72.
  37. Hwang CY, Chen YJ, Lin MW, Chen TJ, Chu SY, Chen CC, Lee DD, Chang YT, Wang WJ, Liu HN. Prevalence of atopic dermatitis, allergic rhinitis and asthma in Taiwan: a national study 2000 to 2007. Acta Derm Venereol 2010;90(6):589-94.
  38. Jaw-Shyang Jih, Yi-Ju Chen1, Ming-Wei Lin, Yu-Chun Chen, Tzeng-Ji Chen, Yu-Lin Huang, Chih-Chiang Chen, Ding-Dar Lee, Yun-Ting Chang, Wen-Jen Wang, Han-Nan Liu. Epidemiological Features and Costs of Herpes Zoster in Taiwan: a National Study 2000 to 2006. Acta Derm Venereol 2009;89(6):612-6.
  39. Huang YL, Chen YJ, Lin MW, Wu CY, Liu PC, Chen TJ, Chen YC, Jih JS, Chen CC, Lee DD, Chang YT, Wang WJ, Liu HN. Malignancies associated with dermatomyositis and polymyositis in Taiwan: a nationwide population-based study. Br J Dermatol 2009;161(4):854-60.
  40. Chang YT, Chen TJ, Liu PC, Chen YC, Chen YJ, Huang YL, Jih JS, Chen CC, Lee DD, Wang WJ, Lin MW, Liu HN. Epidemiological study of psoriasis in the national health insurance database in Taiwan. Acta Derm Venereol 2009;89(3):262-6.
  41. Liu HN, Chang YT, Chen CC, Yang AH. Facial apocrine fibroadenoma in man: a rare finding. Am J Dermatopathol 2007;29(3):274-8.
  42. Chang YT, Hsu CY, Chou CT, Lin MW, Shiao YM, Tsai CY, Yu CW, Shiue JJ, Lee YF, Huang CH, Chen CC, et al. The genetic polymorphisms of POU5F1 gene are associated with psoriasis vulgaris in Chinese. J Dermatol Sci 2007;46(2):153-6.
  43. Chang YT, Chou CT, Yu CW, Lin MW, Shiao YM, Chen CC, et al. Cytokine gene polymorphisms in Chinese patients with psoriasis. Br J Dermatol 2007;156(5):899-905.
  44. Huang CH, Chen CC, Wang CJ, Chang YT, Liu HN. Using desmoglein 1 and 3 enzyme-linked immunosorbent assay as an adjunct diagnostic tool for pemphigus. J Chin Med Assoc 2007;70(2):65-70.
  45. Chih-Chiang Chen, Han-Nan Liu. Clinical and Histological Characteristics of Poroid Neoplasms: A Study of 25 Cases in Taiwan. Int J Dermatol 2006; 45: 722-727.
  46. Chih-Chiang Chen, Chang-Lin Chen. Clinical and Histopathological Findings of Superficial Basal Cell Carcinoma: A Comparison with Other Basal Cell Carcinoma Subtypes. J Chin Med Assoc 2006; 69(8): 364-371.
  47. Han-Nan Liu, Yung-Ting Chang, Chih-Chiang Chen, Cheng-Hung Huang. Histopathological and immunohistochemical studies of poroid hidradenoma. Arch Dermatol Res 2006; 297:319-323.
  48. Cheng-Hung Huang, Chih-Chiang Chen, Chi-Jui Wang, Yun-Ting Chang, Han-Nan Liu. Using BP180 NC16a enzyme-linked immunosorbent assay as an adjust diagnostic tool for bullous pemphigoid. Dermatol Sinica 2006; 24(3):163-170.
  49. Y.T. Chang, H.N. Liu, C.W. Yu, M.W. Lin, C.H. Huang, C.C. Chen, et al. Cytokines gene polymorphisms in bullous pemphigoid in a Chinese population. Br J Dermatol 2006; 154:79-84.
  50. Y.T. Chang, W.R. Lee, C.W. Yu, H.N. Liu, M.W. Lin, C.H. Huang, C.C. Chen, et al. No association of cytokines gene polymorphisms in Chinese patients with atopic dermatitis. Exp Dermatol 2006; 31:419-423.
  51. y.T. Chang, C.T. Chou, Y.M. Shiao, M.W. Lin, C.W. Yu, C.C. Chen, et al. Psoriasis vulgaris in Chinese is associated with PSORS1C3 and CDSN genes. Br J Dermatol 2006; 155:663-669.
  52. yun-Ting Chang, Chan-Te Chou, Yu-Ming Shiao, Ming-Wei Lin, Chia-Wen Yu, Chih-Chiang Chen, et al. The KIR genes do not confer susceptibility to psoriasis vulgaris independently in Chinese. J Invest Dermatol 2006; 126(10):2335- 2338.
  53. Chih-Chiang Chen, Han-Nan Liu. Mixed Merkel cell and Squamous cell carcinoma on the skin. Dermatol Sinica 2004; 22: 74-78.
  54. Han-Nan Liu, Yung-Ting Chang, Chih-Chiang Chen. Differentiation of Hidroacanthoma Simplex from Clonal Seborrheic Keratosis — An immunohistochemical study. Am J Dermatopathol 2004; 26:188-193.
  55. Chen-Yi Wu, Ding-Dar Lee, Chih-Chiang Chen, et al. Hepatocellular Carcinoma with an unusual Cutaneous Metastasis: Report of a Case. Gastroenterol J Taiwan 2003; 20: 24-29
  56. Hong-Jen Chang, Chih-Chiang Chen, Wei Tsauer, Hsu-Sung Kuo, Mei-Ling Hsiao, Pesus Chou. Chin J Public Health 1998;17(1):36-47.