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楊純豪 (Shung-Haur Yang)

楊純豪(Shung-Haur Yang)圖 Return Appointment First Appointment

[Profile]

  • Education
    • Ph. D., Institute of Clinical Dedicine, School of Medicine; National Yang-Ming University, Taipei, Taiwan,
    • M. D., Medical College; National Yang-Ming University, Taipei, Taiwan,
  • Career and Experience
    Current Positions：
    Experiences：
    • - , Chairman, Department of experimental surgery, Taipei Veterans General Hospital,
    • - , Professor of surgery, National Yang-Ming University,
    • - , Attending physician, Department of Colorectal Surgery, Taipei Veterans General Hospital,
  • Medical Expertise
    1. minimal invasive surgery, laparoscopic colorectal surgery, robotic-assisted colorectal surgery
    2. Colorectal cancer research, Diagnosis and treatment of anorectal disease, Colonoscopy and polypectomy
  • License
    Taiwan Surgical Association Taiwan Surgical Society of Gastroenterology The Society of Colon and Rectal Surgeons, Taiwan

[Publications]

  1. Yang, Y. H., Lin, J. K., Chen, W. S., Lin, T. C., Yang, S. H., Jiang, J. K., Lan, Y. T., Lin, C. C., Yen, C. C., Tzeng, C. H., and Teng, H. W. (2014) Comparison of cetuximab to bevacizumab as the first-line bio-chemotherapy for patients with metastatic colorectal cancer: Superior progression-free survival is restricted to patients with measurable tumors and objective tumor response-a retrospective study, J Cancer Res Clin Oncol.
  2. Yang, C. Y., Lu, R. H., Lin, C. H., Jen, C. H., Tung, C. Y., Yang, S. H., Lin, J. K., Jiang, J. K., and Lin, C. H. (2014) Single nucleotide polymorphisms associated with colorectal cancer susceptibility and loss of heterozygosity in a taiwanese population, PLoS One 9, e100060.
  3. Wang, P. H., Tsui, K. H., and Yang, S. H. (2014) Incomplete flexible sigmoidoscopy insertion after cesarean section, J Chin Med Assoc 77, 115-116.
  4. Wang, H. W., Yang, S. H., Huang, G. D., Lin, J. K., Chen, W. S., Jiang, J. K., Lan, Y. T., Lin, C. C., Hwang, W. L., Tzeng, C. H., Li, A. F., Yen, C. C., and Teng, H. W. (2014) Temsirolimus enhances the efficacy of cetuximab in colon cancer through a CIP2A-dependent mechanism, J Cancer Res Clin Oncol 140, 561-571.
  5. Tseng, J. Y., Yang, C. Y., Liang, S. C., Liu, R. S., Yang, S. H., Lin, J. K., Chen, Y. M., Wu, Y. C., Jiang, J. K., and Lin, C. H. (2014) Interleukin-17A modulates circulating tumor cells in tumor draining vein of colorectal cancers and affects metastases, Clinical cancer research : an official journal of the American Association for Cancer Research 20, 2885-2897.
  6. Lin, P. C., Lin, J. K., Lin, C. H., Lin, H. H., Yang, S. H., Jiang, J. K., Chen, W. S., Chou, C. C., Tsai, S. F., and Chang, S. C. (2014) Clinical Relevance of Plasma DNA Methylation in Colorectal Cancer Patients Identified by Using a Genome-Wide High-Resolution Array, Ann Surg Oncol.
  7. Lin, J. K., Lin, P. C., Lin, C. H., Jiang, J. K., Yang, S. H., Liang, W. Y., Chen, W. S., and Chang, S. C. (2014) Clinical Relevance of Alterations in Quantity and Quality of Plasma DNA in Colorectal Cancer Patients: Based on the Mutation Spectra Detected in Primary Tumors, Ann Surg Oncol.
  8. Lin, H. H., Lin, J. K., Jiang, J. K., Lin, C. C., Lan, Y. T., Yang, S. H., Wang, H. S., Chen, W. S., Lin, T. C., Liang, W. Y., and Chang, S. C. (2014) Clinicopathological analysis of colorectal carcinoid tumors and patient outcomes, World journal of surgical oncology 12, 366.
  9. Lin, H. H., Chang, Y. Y., Lin, J. K., Jiang, J. K., Lin, C. C., Lan, Y. T., Yang, S. H., Wang, H. S., Chen, W. S., Lin, T. C., and Chang, S. C. (2014) The role of adjuvant chemotherapy in stage II colorectal cancer patients, Int J Colorectal Dis.
  10. Lin, C. C., Lin, J. K., Lin, T. C., Chen, W. S., Yang, S. H., Wang, H. S., Lan, Y. T., Jiang, J. K., Yang, M. H., and Chang, S. C. (2014) The prognostic role of microsatellite instability, codon-specific KRAS, and BRAF mutations in colon cancer, J Surg Oncol.
  11. Lan, Y. T., Yang, S. H., Lin, J. K., Lin, C. C., Wang, H. S., Chen, W. S., Lin, T. C., Jiang, J. K., and Chang, S. C. (2014) Genetic variations are associated with lymph node metastasis in colorectal cancer patients, J Surg Oncol 110, 307-312.
  12. Lan, Y. T., Chang, S. C., Yang, S. H., Lin, C. C., Wang, H. S., Jiang, J. K., Chen, W. S., Lin, T. C., Chiou, S. H., and Lin, J. K. (2014) Comparison of clinicopathological characteristics and prognosis between early and late recurrence after curative surgery for colorectal cancer, Am J Surg 207, 922-930.
  13. Hwang, W. L., Jiang, J. K., Yang, S. H., Huang, T. S., Lan, H. Y., Teng, H. W., Yang, C. Y., Tsai, Y. P., Lin, C. H., Wang, H. W., and Yang, M. H. (2014) MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells, Nature cell biology 16, 268-280.
  14. Huang, C. S., Lin, J. K., Wang, L. W., Liang, W. Y., Lin, C. C., Lan, Y. T., Wang, H. S., Yang, S. H., Jiang, J. K., Chen, W. S., Lin, T. C., and Chang, S. C. (2014) Assessment of the value of carcinoembryonic antigen reduction ratio as a prognosis factor in rectal cancer, Am J Surg 208, 99-105.
  15. Chen, H. M., Lin, J. K., Chen, W. S., Jiang, J. K., Yang, S. H., Lan, Y. T., Lin, C. C., and Teng, H. W. (2014) Reduced-intensity FOLFOXIRI in Treating Refractory Metastatic Colorectal Cancer: A Pilot Study, American journal of clinical oncology.
  16. Chen, C. C., Lai, Y. L., Jiang, J. K., Chu, C. H., Huang, I. P., Chen, W. S., Cheng, A. Y., and Yang, S. H. (2014) The evolving practice of hybrid natural orifice transluminal endoscopic surgery (NOTES) for rectal cancer, Surg Endosc.
  17. Chang, C. C., Lin, H. H., Lin, J. K., Lin, C. C., Lan, Y. T., Wang, H. S., Yang, S. H., Chen, W. S., Lin, T. C., Jiang, J. K., and Chang, S. C. (2014) FBXW7 mutation analysis and its correlation with clinicopathological features and prognosis in colorectal cancer patients, Int J Biol Markers, 0.
  18. Yang, S. H., Jiang, J.K., Change, S.C., Huang, C.J., Lin, J,K, and Jen-Kou Lin. (2013 ) Clinical Significance of CA19-9 in the Follow-Up of Colorectal Cancer Patients with Elevated Preoperative Serum CA19-9, Hepato-Gastroenterology. 60.
  19. Shao, Y. C., Chang, Y. Y., Lin, J. K., Lin, C. C., Wang, H. S., Yang, S. H., Jiang, J. K., Lan, Y. T., Lin, T. C., Li, A. F., Chen, W. S., and Chang, S. C. (2013) Neoadjuvant chemotherapy can improve outcome of colorectal cancer patients with unresectable metastasis, Int J Colorectal Dis.
  20. Lu, Y. J., Lin, P. C., Lin, C. C., Wang, H. S., Yang, S. H., Jiang, J. K., Lan, Y. T., Lin, T. C., Liang, W. Y., Chen, W. S., Lin, J. K., and Chang, S. C. (2013) The Impact of the Lymph Node Ratio is Greater than Traditional Lymph Node Status in Stage III Colorectal Cancer Patients, World J Surg.
  21. Ling-Wei Wang, T.-J. C., Chong-Yau Fu,  Jen-Kou Lin,  Shung-Haur Yang, . (2013) The Status of Sphincter-Preserving Surgery for Rectal Cancer in Taiwan: a 10-year Population-based Study, Hepatogastroenterology.
  22. Lin, S. P., Lee, Y. T., Yang, S. H., Miller, S. A., Chiou, S. H., Hung, M. C., and Hung, S. C. (2013) Colon cancer stem cells resist antiangiogenesis therapy-induced apoptosis, Cancer Lett 328, 226-234.
  23. Huang, C. J., Teng, H. W., Chien, C. C., Lin, J. K., and Yang, S. H. (2013) Prognostic Significance of C-Reactive Protein Polymorphism and KRAS/BRAF in Synchronous Liver Metastasis from Colorectal Cancer, PLoS One 8, e65117.
  24. Yang, Y. H., Lin, J. K., Chen, W. S., Lin, T. C., Yang, S. H., Jiang, J. K., Chang, S. C., Lan, Y. T., Lin, C. C., Yen, C. C., Tzeng, C. H., Wang, W. S., Chiang, H. L., Teng, C. J., and Teng, H. W. (2012) Duloxetine improves oxaliplatin-induced neuropathy in patients with colorectal cancer: an open-label pilot study, Support Care Cancer 20, 1491-1497.
  25. Teng, H. W., Yang, S. H., Lin, J. K., Chen, W. S., Lin, T. C., Jiang, J. K., Yen, C. C., Li, A. F., Chen, P. C., Lan, Y. T., Lin, C. C., Hsu, Y. N., Wang, H. W., and Chen, K. F. (2012) CIP2A is a predictor of poor prognosis in colon cancer, J Gastrointest Surg 16, 1037-1047.
  26. Teng, H. W., Huang, Y. C., Lin, J. K., Chen, W. S., Lin, T. C., Jiang, J. K., Yen, C. C., Li, A. F., Wang, H. W., Chang, S. C., Lan, Y. T., Lin, C. C., Wang, H. S., and Yang, S. H. (2012) BRAF mutation is a prognostic biomarker for colorectal liver metastasectomy, J Surg Oncol 106, 123-129.
  27. Lin, P. C., Lin, J. K., Lin, C. C., Wang, H. S., Yang, S. H., Jiang, J. K., Lan, Y. T., Lin, T. C., Li, A. F., Chen, W. S., and Chang, S. C. (2012) Carbohydrate antigen 19-9 is a valuable prognostic factor in colorectal cancer patients with normal levels of carcinoembryonic antigen and may help predict lung metastasis, Int J Colorectal Dis 27, 1333-1338.
  28. Lin, J. K., Lee, L. K., Chen, W. S., Lin, T. C., Jiang, J. K., Yang, S. H., Wang, H. S., Chang, S. C., Lan, Y. T., Lin, C. C., Yen, C. C., Liu, J. H., Tzeng, C. H., and Teng, H. W. (2012) Concurrent chemoradiotherapy followed by metastasectomy converts to survival benefit in stage IV rectum cancer, J Gastrointest Surg 16, 1888-1896.
  29. Lin, C. C., Lai, Y. L., Lin, T. C., Chen, W. S., Jiang, J. K., Yang, S. H., Wang, H. S., Lan, Y. T., Liang, W. Y., Hsu, H. M., Lin, J. K., and Chang, S. C. (2012) Clinicopathologic features and prognostic analysis of MSI-high colon cancer, Int J Colorectal Dis 27, 277-286.
  30. Lan, Y. T., Yang, S. H., Chang, S. C., Liang, W. Y., Li, A. F., Wang, H. S., Jiang, J. K., Chen, W. S., Lin, T. C., and Lin, J. K. (2012) Analysis of the seventh edition of American Joint Committee on colon cancer staging, Int J Colorectal Dis 27, 657-663.
  31. Lan, Y. T., Lin, J. K., Lin, T. C., Chen, W. S., Jiang, J. K., Wang, H. S., Chang, S. C., and Yang, S. H. (2012) Prognostic significance of perioperative change of CEA level in colorectal patients when pre-operative level is normal, Hepatogastroenterology 59, 717-720.
  32. Chien, C. C., Tu, T. C., Huang, C. J., Yang, S. H., and Lee, C. L. (2012) Lowly expressed ribosomal protein s19 in the feces of patients with colorectal cancer, ISRN Gastroenterol 2012, 394545.
  33. Yang, S. H., Huang, C. J., Chang, S. C., and Lin, J. K. (2011) Association of C-reactive protein gene polymorphisms and colorectal cancer, Ann Surg Oncol 18, 1907-1915.
  34. Tsai, K. S., Yang, S. H., Lei, Y. P., Tsai, C. C., Chen, H. W., Hsu, C. Y., Chen, L. L., Wang, H. W., Miller, S. A., Chiou, S. H., Hung, M. C., and Hung, S. C. (2011) Mesenchymal stem cells promote formation of colorectal tumors in mice, Gastroenterology 141, 1046-1056.
  35. Liu, C. J., Lin, J. K., Chen, W. S., Lin, T. C., Yang, S. H., Jiang, J. K., Chang, S. C., Lan, Y. T., Yen, C. C., Tzeng, C. H., Wang, H. W., and Teng, H. W. (2011) The efficacy of chemotherapy in patients with high-grade metastatic colon cancer, Hepatogastroenterology 58, 1495-1501.
  36. Lin, J. K., Yueh, T. C., Chang, S. C., Lin, C. C., Lan, Y. T., Wang, H. S., Yang, S. H., Jiang, J. K., Chen, W. S., and Lin, T. C. (2011) The influence of fecal diversion and anastomotic leakage on survival after resection of rectal cancer, J Gastrointest Surg 15, 2251-2261.
  37. Lin, J. K., Lin, C. C., Yang, S. H., Wang, H. S., Jiang, J. K., Lan, Y. T., Lin, T. C., Li, A. F., Chen, W. S., and Chang, S. C. (2011) Early postoperative CEA level is a better prognostic indicator than is preoperative CEA level in predicting prognosis of patients with curable colorectal cancer, Int J Colorectal Dis 26, 1135-1141.
  38. Lin, J. K., Lin, A. J., Lin, C. C., Lan, Y. T., Yang, S. H., Li, A. F., and Chang, S. C. (2011) The status of EGFR-associated genes could predict the outcome and tumor response of chemo-refractory metastatic colorectal patients using cetuximab and chemotherapy, J Surg Oncol.
  39. Lin, C. C., Lai, Y. L., Lin, T. C., Chen, W. S., Jiang, J. K., Yang, S. H., Wang, H. S., Lan, Y. T., Liang, W. Y., Hsu, H. M., Lin, J. K., and Chang, S. C. (2011) Clinicopathologic features and prognostic analysis of MSI-high colon cancer, Int J Colorectal Dis.
  40. Lan, Y. T., Lin, J. K., Jiang, J. K., Chang, S. C., Liang, W. Y., and Yang, S. H. (2011) Significance of lymph node retrieval from the terminal ileum for patients with cecal and ascending colonic cancers, Ann Surg Oncol 18, 146-152.
  41. Hwang, W. L., Yang, M. H., Tsai, M. L., Lan, H. Y., Su, S. H., Chang, S. C., Teng, H. W., Yang, S. H., Lan, Y. T., Chiou, S. H., and Wang, H. W. (2011) SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells, Gastroenterology 141, 279-291, 291 e271-275.
  42. Huang, Y. C., Lin, J. K., Chen, W. S., Lin, T. C., Yang, S. H., Jiang, J. K., Chang, S. C., Lan, Y. T., Wang, H. S., Liu, C. Y., Yang, Y. W., and Teng, H. W. (2011) Diabetes mellitus negatively impacts survival of patients with colon cancer, particularly in stage II disease, J Cancer Res Clin Oncol 137, 211-220.
  43. Huang, C. J., Yang, S. H., Huang, S. M., Lin, C. M., Chien, C. C., Chen, Y. C., Lee, C. L., Wu, H. H., and Chang, C. C. (2011) A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment, J Transl Med 9, 82.
  44. Hsu, Y. N., Liu, C. J., Lin, J. K., Chen, W. S., Lin, T. C., Yang, S. H., Jiang, J. K., Chang, S. C., Lan, Y. T., Lin, C. C., Yen, C. C., Liu, J. H., Tzeng, C. H., and Teng, H. W. (2011) Liver abscess after liver metastasectomy is a poor prognostic factor in patients with colorectal cancer, J Gastrointest Surg 15, 1798-1806.
  45. Hsu, Y. N., Lin, J. K., Chen, W. S., Lin, T. C., Yang, S. H., Jiang, J. K., Chang, S. C., Yen, C. C., Tzeng, C. H., and Teng, H. W. (2011) A new classification scheme for recurrent or metastatic colon cancer after liver metastasectomy, J Chin Med Assoc 74, 493-499.
  46. Chou, C. L., Chang, S. C., Lin, T. C., Chen, W. S., Jiang, J. K., Wang, H. S., Yang, S. H., Liang, W. Y., and Lin, J. K. (2011) Differences in clinicopathological characteristics of colorectal cancer between younger and elderly patients: an analysis of 322 patients from a single institution, Am J Surg 202, 574-582.
  47. Yang Shung-Haur, C.-J. H., Chia-Long Lee, Chen-Chiung Liu, Chih-Cheng Chie, Shu-Hung Chen. (2010) Fecal RNA Detection of Cytokeratin 19 and Ribosomal Protein L19 for Colorectal Cancer, Hepato-Gastroenterology. 57, 710-715.
  48. Yang, R. N., Yang, S. H., Chang, C. C., Chien, C. C., Pan, S., and Huang, C. J. (2010) Upregulation of fecal cytokeratin 19 is associated with prognosis in older colorectal cancer patients, Genet Test Mol Biomarkers 14, 703-708.
  49. Lin, J. K., Shen, M. Y., Lin, T. C., Lan, Y. T., Wang, H. S., Yang, S. H., Li, A. F., and Chang, S. C. (2010) Distribution of a single nucleotide polymorphism of insulin-like growth factor-1 in colorectal cancer patients and its association with mucinous adenocarcinoma, Int J Biol Markers 25, 195-199.
  50. Lan, Y. T., Yang, S. H., Li, A. F., and Lin, J. K. (2010) Conflicting finding on intramucosal colon cancers based on national survival outcomes data, J Clin Oncol 28, e469; author reply e470.
  51. Kao, P. S., Chang, S. C., Wang, L. W., Lee, R. C., Liang, W. Y., Lin, T. C., Chen, W. S., Jiang, J. K., Yang, S. H., Wang, H. S., and Lin, J. K. (2010) The impact of preoperative chemoradiotherapy on advanced low rectal cancer, J Surg Oncol 102, 771-777.
  52. Huang, Y. C., Lin, J. K., Chen, W. S., Lin, T. C., Yang, S. H., Jiang, J. K., Chang, S. C., Lan, Y. T., Wang, H. S., Liu, C. Y., Yang, Y. W., and Teng, H. W. (2010) Diabetes mellitus negatively impacts survival of patients with colon cancer, particularly in stage II disease, J Cancer Res Clin Oncol.
  53. Chang, S. C., Lin, P. C., Yang, S. H., Wang, H. S., Liang, W. Y., and Lin, J. K. (2010) Taiwan hospital-based detection of Lynch syndrome distinguishes 2 types of microsatellite instabilities in colorectal cancers, Surgery 147, 720-728.
  54. Lin, C. C., Lin, J. K., Chang, S. C., Wang, H. S., Yang, S. H., Jiang, J. K., Chen, W. S., and Lin, T. C. (2009) Is adjuvant chemotherapy beneficial to high risk stage II colon cancer? Analysis in a single institute, International Journal of Colorectal Disease 24, 665-676.
  55. Lai, R. H., Wang, M. J., Yang, S. H., and Chen, J. Y. (2009) Genomic organization and functional characterization of the promoter for the human suppressor of cytokine signaling 6 gene, Gene 448, 64-73.
  56. Chang, S. C., Lin, P. C., Yang, S. H., Wang, H. S., Liang, W. Y., and Lin, J. K. (2009) Mitochondrial D-loop mutation is a common event in colorectal cancers with p53 mutations, International Journal of Colorectal Disease 24, 623-628.
  57. Chang, S. C., Lin, P. C., Yang, S. H., Wang, H. S., Li, A. F., and Lin, J. K. (2009) SDF-1alpha G801A polymorphism predicts lymph node metastasis in stage T3 colorectal cancer, Ann Surg Oncol 16, 2323-2330.
  58. Chang, C. C., Yang, S. H., Chien, C. C., Chen, S. H., Pan, S., Lee, C. L., Lin, C. M., Sun, H. L., Huang, C. C., Wu, Y. Y., Yang, R. N., and Huang, C. J. (2009) Clinical meaning of age-related expression of fecal cytokeratin 19 in colorectal malignancy, BMC Cancer 9, 376.
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