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張世慶 (Shih-Ching Chang)

張世慶(Shih-Ching Chang)圖 Return Appointment First Appointment

[Profile]

  • Education
    • 博士, 臨床醫學研究所; 國立陽明大學,
    • 學士, 醫學系; 國立陽明大學,
  • Career and Experience
    Current Positions：
    • - Now, 教授, 醫學系外科學科, 國立陽明大學,
    • - Now, 科主任, 外科部大腸直腸外科, 台北榮民總醫院,
    • - Now, 主治醫師, 外科部大腸直腸外科, 臺北榮民總醫院,
    • - Now, 理事, 中華民國大腸直腸外科醫學會,
    Experiences：
    • - , 臨床研究員, 美國 MD Anderson 癌症中心,
    • - , 住院總醫師, 外科部, 臺北榮民總醫院,
    • - , 住院醫師, 外科部, 臺北榮民總醫院,
  • Medical Expertise
    1. 大腸直腸癌手術、大腸鏡檢查,息肉切除、遺傳性癌症篩檢、肛門疾病
    2. 痔瘡、 肛裂、 肛門瘻管、肛門膿瘍
    3. 大腸直腸肛門良性病灶、惡性腫瘤診斷及手術治療
    4. 大腸內視鏡診斷與治療
    5. 惡性腫瘤診斷及腹腔鏡微創手術治療&達文西機械手臂手術
  • License
    中華民國大腸直腸外科醫學會專科醫師 　 台灣外科醫學會專科醫師 中華民國大腸直腸外科醫學會達文西機械手臂輔助直腸手術證書

[Publications]

  1. Chou CL, Lin JK, Wang HS, Yang SH, Li AF, Chang SC.* Microsatellite instability screening should be done for right-sided colon cancer patients less than 60 years of age. Int J Colorectal Dis 2010;25:47-52. doi:10.1007/s00384-009-0815-y
  2. Chang SC, Lin PC, Yang SH, Wang HS, Liang WY, Lin JK. Taiwan hospital-based detection of Lynch syndrome distinguishes 2 types of microsatellite instabilities in colorectal cancers. Surgery 2010;147:720-8. doi:10.1016/j.surg.2009.10.069
  3. Kao PS, Chang SC, Wang LW, Lee RC, Liang WY, Lin TC, Chen WS, Jiang JK, Yang SH, Wang HS, Lin JK. The impact of preoperative chemoradiotherapy on advanced low rectal cancer. J Surg Oncol 2010;102:771-7. doi:10.1002/jso.21711
  4. Lin JK, Shen MY, Lin TC, Lan YT, Wang HS, Yang SH, Li AF, Chang SC.* Distribution of a single nucleotide polymorphism of insulin-like growth factor-1 in colorectal cancer patients and its association with mucinous adenocarcinoma. Int J Biol Markers 2010;25:195-9
  5. Wang SC, Lin JK, Wang HS, Yang SH, Li AF, Chang SC.* Nuclear expression of CXCR4 is associated with advanced colorectal cancer. Int J Colorectal Dis 2010;25:1185-91. doi:10.1007/s00384-010-0999-1
  6. Lai YL, Lin JK, Liang WY, Huang YC, Chang SC.* Surgical resection combined with chemotherapy can help achieve better outcomes in patients with primary colonic lymphoma. J Surg Oncol 2011;104:265-8. doi:10.1002/jso.21927
  7. Lin JK, Lin CC, Yang SH, Wang HS, Jiang JK, Lan YT, Lin TC, Li AF, Chen WS, Chang SC.* Early postoperative CEA level is a better prognostic indicator than is preoperative CEA level in predicting prognosis of patients with curable colorectal cancer. Int J Colorectal Dis 2011;26:1135-41. doi:10.1007/s00384-011-1209-5
  8. Lin CH, Lin JK, Chang SC, Chang YH, Chang HM, Liu JH, Li LH, Chen YT, Tsai SF, Chen WS. Molecular profile and copy number analysis of sporadic colorectal cancer in Taiwan. J Biomed Sci 2011;18:36. doi:10.1186/1423-0127-18-36
  9. Lin JK, Lin AJ, Lin CC, Lan YT, Yang SH, Li AF, Chang SC.* The status of EGFR-associated genes could predict the outcome and tumor response of chemo-refractory metastatic colorectal patients using cetuximab and chemotherapy. J Surg Oncol 2011;104:661-6. doi:10.1002/jso.21993
  10. Hwang WL, Yang MH, Tsai ML, Lan HY, Su SH, Chang SC, Teng HW, Yang SH, Lan YT, Chiou SH, Wang HW. SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. Gastroenterology 2011;141:279-91, 91 e1-5. doi:10.1053/j.gastro.2011.04.008
  11. Lin JK, Yueh TC, Chang SC, Lin CC, Lan YT, Wang HS, Yang SH, Jiang JK, Chen WS, Lin TC. The influence of fecal diversion and anastomotic leakage on survival after resection of rectal cancer. J Gastrointest Surg 2011;15:2251-61. doi:10.1007/s11605-011-1721-5
  12. Chou CL, Chang SC, Lin TC, Chen WS, Jiang JK, Wang HS, Yang SH, Liang WY, Lin JK. Differences in clinicopathological characteristics of colorectal cancer between younger and elderly patients: an analysis of 322 patients from a single institution. Am J Surg 2011;202:574-82. doi:10.1016/j.amjsurg.2010.10.014
  13. Lin CC, Lai YL, Lin TC, Chen WS, Jiang JK, Yang SH, Wang HS, Lan YT, Liang WY, Hsu HM, Lin JK, Chang SC.* Clinicopathologic features and prognostic analysis of MSI-high colon cancer. Int J Colorectal Dis 2012;27:277-86. doi:10.1007/s00384-011-1341-2
  14. Lin PC, Lin JK, Lin CC, Wang HS, Yang SH, Jiang JK, Lan YT, Lin TC, Li AF, Chen WS, Chang SC.* Carbohydrate antigen 19-9 is a valuable prognostic factor in colorectal cancer patients with normal levels of carcinoembryonic antigen and may help predict lung metastasis. Int J Colorectal Dis 2012;27:1333-8. doi:10.1007/s00384-012-1447-1
  15. Chou CL, Weng SF, Lin JK, Chang SC.* Role for gender in colorectal cancer risk: a Taiwan population-based study. Int J Colorectal Dis 2013;28:1001-8. doi:10.1007/s00384-013-1647-3
  16. Lin PC, Lin HH, Lin JK, Lin CC, Yang SH, Li AF, Chen WS, Chang SC.* Expression of ABCG2 associated with tumor response in metastatic colorectal cancer patients receiving first-line FOLFOX therapy--preliminary evidence. Int J Biol Markers 2013;28:182-6. doi:10.5301/jbm.5000004
  17. Fang WL, Chang SC, Lan YT, Huang KH, Chen JH, Lo SS, Hsieh MC, Li AF, Wu CW, Chiou SH. Microsatellite instability is associated with a better prognosis for gastric cancer patients after curative surgery. World J Surg 2012;36:2131-8. doi:10.1007/s00268-012-1652-7
  18. Fang WL, Chang SC, Lan YT, Huang KH, Lo SS, Li AF, Chi CW, Wu CW, Chiou SH. Molecular and survival differences between familial and sporadic gastric cancers. Biomed Res Int 2013;2013:396272. doi:10.1155/2013/396272
  19. Lu YJ, Lin PC, Lin CC, Wang HS, Yang SH, Jiang JK, Lan YT, Lin TC, Liang WY, Chen WS, Lin JK, Chang SC*. The impact of the lymph node ratio is greater than traditional lymph node status in stage III colorectal cancer patients. World J Surg 2013;37:1927-33. doi:10.1007/s00268-013-2051-4
  20. Shao YC, Chang YY, Lin JK, Lin CC, Wang HS, Yang SH, Jiang JK, Lan YT, Lin TC, Li AF, Chen WS, Chang SC.* Neoadjuvant chemotherapy can improve outcome of colorectal cancer patients with unresectable metastasis. Int J Colorectal Dis 2013;28:1359-65. doi:10.1007/s00384-013-1713-x
  21. Lin HH, Lin JK, Lin CC, Lan YT, Wang HS, Yang SH, Jiang JK, Chen WS, Lin TC, Liang WY, Chang SC*. Circumferential margin plays an independent impact on the outcome of rectal cancer patients receiving curative total mesorectal excision. Am J Surg 2013;206:771-7. doi:10.1016/j.amjsurg.2013.03.009
  22. Huang CS, Lin JK, Wang LW, Liang WY, Lin CC, Lan YT, Wang HS, Yang SH, Jiang JK, Chen WS, Lin TC, Chang SC*. Assessment of the value of carcinoembryonic antigen reduction ratio as a prognosis factor in rectal cancer. Am J Surg 2014;208:99-105. doi:10.1016/j.amjsurg.2013.08.054
  23. Lin CC, Lin JK, Lin TC, Chen WS, Yang SH, Wang HS, Lan YT, Jiang JK, Yang MH, Chang SC*. The prognostic role of microsatellite instability, codon-specific KRAS, and BRAF mutations in colon cancer. J Surg Oncol 2014;110:451-7. doi:10.1002/jso.23675
  24. Lin HH, Chang YY, Lin JK, Jiang JK, Lin CC, Lan YT, Yang SH, Wang HS, Chen WS, Lin TC, Chang SC*. The role of adjuvant chemotherapy in stage II colorectal cancer patients. Int J Colorectal Dis 2014;29:1237-43. doi:10.1007/s00384-014-1943-6
  25. Lin JK, Lin PC, Lin CH, Jiang JK, Yang SH, Liang WY, Chen WS, Chang SC*. Clinical relevance of alterations in quantity and quality of plasma DNA in colorectal cancer patients: based on the mutation spectra detected in primary tumors. Ann Surg Oncol 2014;21 Suppl 4:680-6. doi:10.1245/s10434-014-3804-5
  26. Lan YT, Yang SH, Lin JK, Lin CC, Wang HS, Chen WS, Lin TC, Jiang JK, Chang SC*. Genetic variations are associated with lymph node metastasis in colorectal cancer patients. J Surg Oncol 2014;110:307-12. doi:10.1002/jso.23613
  27. Lin PC, Lin JK, Lin CH, Lin HH, Yang SH, Jiang JK, Chen WS, Chou CC, Tsai SF, Chang SC*. Clinical Relevance of Plasma DNA Methylation in Colorectal Cancer Patients Identified by Using a Genome-Wide High-Resolution Array. Ann Surg Oncol 2014. doi:10.1245/s10434-014-4277-
  28. Hang JF, Li AF, Chang SC, Liang WY. Immunohistochemical detection of BRAF V600E mutant protein in colorectal cancers in Taiwan is highly concordant with the molecular test. Histopathology 2015. doi:10.1111/his.12903Chang SC, Lin PC, Lin JK, Lin CH, Yang SH, Liang WY, Chen WS, Jiang JK. Mutation Spectra of Common Cancer-Associated Genes in Different Phenotypes of Colorectal Carcinoma Without Distant Metastasis. Ann Surg Oncol 2015. doi:10.1245/s10434-015-4899-z
  29. Lin HH, Yang HL, Lin JK, Lin CC, Wang HS, Yang SH, Jiang JK, Lan YT, Lin TC, Chen WS, Liang WY, Chang SC. The Number of Risk Factors Determines the Outcome Of Stage II Colorectal Cancer Patients. Hepatogastroenterology 2014;61:1024-7
  30. Lee YT, Liu CJ, Hu YW, Teng CJ, Tzeng CH, Yeh CM, Chen TJ, Lin JK, Lin CC, Lan YT, Wang HS, Yang SH, Jiang JK, Chen WS, Lin TC, Chang SC, Chen MH, Teng HW, Liu JH, Yen CC. Incidence of Second Primary Malignancies Following Colorectal Cancer: A Distinct Pattern of Occurrence Between Colon and Rectal Cancers and Association of Co-Morbidity with Second Primary Malignancies in a Population-Based Cohort of 98,876 Patients in Taiwan. Medicine (Baltimore) 2015;94:e1079. doi:10.1097/md.0000000000001079
  31. Lin PC, Lin JK, Lin HH, Lan YT, Lin CC, Yang SH, Chen WS, Liang WY, Jiang JK, Chang SC. A comprehensive analysis of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) loss in colorectal cancer. World J Surg Oncol 2015;13:186. doi:10.1186/s12957-015-0601-y
  32. Lan YT, Jen-Kou L, Lin CH, Yang SH, Lin CC, Wang HS, Chen WS, Lin TC, Jiang JK, Chang SC. Mutations in the RAS and PI3K pathways are associated with metastatic location in colorectal cancers. J Surg Oncol 2015;111:905-10. doi:10.1002/jso.23895
  33. Huang CS, Yang SH, Lin CC, Lan YT, Chang SC, Wang HS, Chen WS, Lin TC, Lin JK, Jiang JK. Synchronous and metachronous colorectal cancers: distinct disease entities or different disease courses? Hepatogastroenterology 2015;62:286-90
  34. Chang YY, Lin JK, Lin TC, Chen WS, Jeng KJ, Yang SH, Wang HS, Lan YT, Lin CC, Liang WY, Chang SC. Impact of KRAS mutation on outcome of patients with metastatic colorectal cancer. Hepatogastroenterology 2014;61:1946-53
  35. Huang SC, Lin JK, Lin TC, Chen WS, Yang SH, Wang HS, Lan YT, Lin CC, Jiang JK, Chang SC. Concordance of Carcinoembryonic Antigen Ratio and Response Evaluation Criteria in Solid Tumors as Prognostic Surrogate Indicators of Metastatic Colorectal Cancer Patients Treated with Chemotherapy. Ann Surg Oncol 2015;22:2262-8. doi:10.1245/s10434-014-4228-y

 

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