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何祥齡 (Hsiang-Ling Ho)

何祥齡(Hsiang-Ling Ho)圖 Return Appointment First Appointment

[Profile]

  • Education
    • B.S., Department of Biotechnology and Laboratory Science in Medicine; National Yang-Ming University,
    • Ph.D, Institute of Biochemistry and Molecular Biology; National Yang-Ming University,
  • Career and Experience
    Current Positions：
    • 2017- Now, Section Chief, Division of Core Laboratory, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital,
    • 2018- Now, Adjunct Associate Professor, Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University,,
    Experiences：
    • - , Chief medical technologist, Division of Molecular Pathology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital,
    • - , Medical technologist, Division of Surgical Pathology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital,
    • - , Post-doctoral fellow, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital,
    • - , Post-doctoral fellow, Institute of Biomedical Sciences, Academia Sinica,
  • Medical Expertise
    1. Molecular biology
    2. Laboratory medicine
    3. Laboratory management and quality control
  • License
    License of Medical Technologist, Taiwan License of Molecular Diagnostics, Taiwan Society of Laboratory Medicine
  • Language Expertise
    Mandarin, Taiwanese, English

[Publications]

  1. Chiang CL, Ho HL, Yeh YC, Lee CC, Huang HC, Shen CI, Luo YH, Chen YM, Chiu CH*, Chou TY*. Prognosticators of osimertinib treatment outcomes in patients with EGFR-mutant non-small cell lung cancer and leptomeningeal metastasis. J Cancer Res Clin Oncol. 2022 Nov 1. doi: 10.1007/s00432-022-04396-1. Online ahead of print.
  2. Ho HL*, Wang FY, Chiang CL, Tsai CM, Chiu CH, Chou TY*. Dynamic assessment of tissue and plasma EGFR-activating and T790M mutations with droplet digital PCR assays for monitoring response and resistance in non-small cell lung cancers treated with EGFR-TKIs. Int J Mol Sci. 23(19):11353, 2022. (*co-corresponding authors)
  3. Yeh YC, Ma HH, Chu PY, Ho HL, Chou TY*. Programmed Death-Ligand 1 Expression in Lymphovascular Tumor Emboli in Lung Cancer. JTO Clin Res Rep. 3(7):100349, 2022.
  4. Chang WC, Yeh YC, Ho HL, Chou TY*. Deep exploration of immune function in EGFR wild-type and mutated lung adenocarcinomas by gene expression profiling: role of TRAIL-R2 (TNFRSF10B) in patient treatment and outcome. Hum Pathol. 126:9-18, 2022.
  5. Lee HR, Wang FY, Li JL, Chou TY, Ho HL*. Real-world Evaluation of a Sample Pooling Strategy for Large-Scale Rapid COVID-19 Testing. J Clin Virol. 2022 Apr; 149:105133. doi: 10.1016/j.jcv.2022.105133.
  6. Ho HL, Jiang Y, Chiang CL, Karwowska S, Yerram R, Sharma K, Scudder S, Chiu CH, Tsai CM, Palma JF, Sharma A*, Chou TY*. Efficacy of liquid biopsy for disease monitoring and early prediction of tumor progression in EGFR mutation-positive non-small cell lung cancer. PLoS One. 17(4): e0267362, 2022
  7. Chang YH, Yang HJ, Chen HW, Hsiao CW, Hsieh YC, Chan YW, Chang SW, Hwang WL, Chen WS, Cheng HH, Chou TY, Chang FP, Ho HL, Chu FY, Lo YL, Chen CJ, Tsai HF, Shiau MY*. Characterization of Collapsin Response Mediator Protein 2 in Colorectal Cancer Progression in Subjects with Diabetic Comorbidity. Cells. 11(4):727, 2022
  8. Lin YY, Wang YC, Yeh DW, Hung CY, Yeh YC, Ho HL, Mon HC, Chen MY, Wu YC, Chou TY*. Gene Expression Profile in Primary Tumor Is Associated with Brain-Tropism of Metastasis from Lung Adenocarcinoma. Int J Mol Sci. 22(24):13374, 2021 
  9. Ho HL*, Lin YY, Wang FY, Wu CH, Lee CL and Chou TY. Establishing diagnostic algorithms for SARS-CoV-2 nucleic acid testing in clinical practice. J Chin Med Assoc. 84(12): 1120-1125, 2021
  10. Yeh YC, Ho HL, Linc CI, Chou TY, Wang YC*. Whole-exome Sequencing of Epstein-Barr Virus-associated Pulmonary Carcinoma with Low Lymphocytic Infiltration Shows Molecular Features Similar to Those of Classic Pulmonary Lymphoepithelioma-like Carcinoma: Evidence to Support Grouping Together as One Disease Entity. Am J Surg Pathol. 45(11):1476-1486, 2021
  11. Chen PL, Hsiao YH, Chuang C, Feng JY, Ho HL, Lin YT, Chen SJ, Huang SF, Chen HP, Chou TY, Chen YM*, Wang FD*. The Clinical Manifestations and Interval Changes of Reverse-Transcriptase Quantitative Polymerase Chain Reactions among Different Specimens of Coronavirus Disease 2019 Patients. J Chin Med Assoc. 84(2):151-157, 2021
  12. Lin SY, Hang JF, Lin YY, Lai CR, Ho HL*, Chou TY*. Diffuse Intratumoral Stromal Inflammation in Ovarian Clear Cell Carcinoma is Associated with Loss of Mismatch Repair Protein and High PD-L1 Expression. Int J Gynecol Pathol. 40(2):148-155. 2021 (*co-corresponding authors)
  13. Wang LC, Lin TC, Yeh YC, Ho HL*, Tsai CC, Chou TY*. Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Somatic Mutations in CDH1 and Other Clinically Actionable Mutations Imply Early Use of Targeted Agents. Curr Oncol. 28(1):918-927. 2021 (*co-corresponding authors)
  14. Lin YY, Lin LY, Hang JF, Lin CH, Ho HL, Chou TY*. Programmed death-ligand 1 (PD-L1)/thyroid transcription factor-1 double immunohistochemical staining facilitates scoring of tumor PD-L1 expression in cytopathology specimens from lung adenocarcinoma patients. Cancer Cytopathol. 129(2):148-155, 2021
  15. Ho HL, Wang FY, Lee HR, Huang YL, Lai CL, Jen WC, Hsieh SL, Chou TY*. Seroprevalence of COVID-19 in Taiwan revealed by testing anti-SARS-CoV-2 serological antibodies on 14,765 hospital patients. The Lancet Regional Health - Western Pacific 3, 2020, 100041
  16. Yeh YC, Ho HL, Wu YC, Pan CC, Wang YC*, Chou TY*. AKT1 internal tandem duplications and point mutations are the genetic hallmarks of sclerosing pneumocytoma. Mod Pathol. 33(3):391-403, 2020
  17. Shen CI, Ho HL, Yeh YC, Chiu CH*, Chou TY. Epidermal growth factor receptor mutations in non-small cell lung cancer undetected by high-sensitivity allele-specific real-time polymerase chain reaction-based assays. J Chin Med Assoc. 83(4):345-349, 2020
  18. Wang ML, Hsu YF, Liu CH, Kuo YL, Chen YC, Yeh YC, Ho HL, Wu YC, Chou TY*, Wu CW*. Low-Dose Nicotine Activates EGFR Signaling via α5-nAChR and Promotes Lung Adenocarcinoma Progression. Int J Mol Sci.21(18):6829, 2020
  19. Ho HL, Chou TY, Yang SH, Jiang JK, Chen WS, Chao Y, Teng HW*. PD-L1 is a double-edged sword in colorectal cancer: the prognostic value of PD-L1 depends on the cell type expressing PD-L1. J Cancer Res Clin Oncol. 145(7):1785-1794, 2019
  20. Chen YY, Ho HL, Lin SC, Hsu CY*, Ho DM. Loss of BCAT1 Expression is a Sensitive Marker for IDH-Mutant Diffuse Glioma. Neurosurgery. 85(3):335-342, 2019
  21. Chang WC, Yeh YC, Ho HL, Hsieh SL, Chou TY*. Decoy Receptor 3 Expression Is Associated With Wild-Type EGFR Status, Poor Differentiation of Tumor, and Unfavorable Patient Outcome. Am J Clin Pathol. 152(2):207-216, 2019
  22. Lin CS, Huang YY, Pan SC, Cheng CT, Liu CC, Shih CH, Ho HL, Yeh YC, Chou TY, Lee MY*, Wei YH*. Involvement of increased p53 expression in the decrease of mitochondrial DNA copy number and increase of SUV max of FDG-PET scan in esophageal squamous cell carcinoma. Mitochondrion. 47:54-63, 2019
  23. Yeh YC, Kao HL, Lee KL, Wu MH, Ho HL, Chou TY*. Epstein-Barr Virus-Associated Pulmonary Carcinoma: Proposing an Alternative Term and Expanding the Histologic Spectrum of Lymphoepithelioma-like Carcinoma of the Lung. Am J Surg Pathol. 43(2):211-219, 2019
  24. Ho HL, Huang CC, Ku WH, Ho CL, Lin CH, Yu SL*, Chou TY*. Liquid biopsy for detection of EGFR T790M mutation in non-small cell lung cancer: An experience of proficiency testing in Taiwan. J Chin Med Assoc. 82(6):473-476, 2019
  25. Ho HL, Kao HL, Yeh YC, Chou TY*. The importance of EGFR mutation testing in squamous cell carcinoma or non-small cell carcinoma favor squamous cell carcinoma diagnosed from small lung biopsies. Diagn Pathol. 14(1):59, 2019
  26. Tseng YH, Ho HL, Lai CR, Luo YH, Tseng YC, Whang-Peng J, Lin YH, Chou TY, Chen YM*. PD-L1 Expression of Tumor Cells, Macrophages, and Immune Cells in Non-Small Cell Lung Cancer Patients with Malignant Pleural Effusion. J Thorac Oncol. 13(3):447-453, 2018
  27. Chen YY, Ho HL, Lin SC, Ho TD, Hsu CY*. Upregulation of miR-125b, miR-181d, and miR-221 Predicts Poor Prognosis in MGMT Promoter-Unmethylated Glioblastoma Patients. Am J Clin Pathol. 149(5):412-417, 2018
  28. Lin YC, Lin CH, Yeh YC, Ho HL, Wu YC, Chen MY*, Chou TY*. High O-linked N-acetylglucosamine transferase expression predicts poor survival in patients with early stage lung adenocarcinoma. Oncotarget. 9(57):31032-31044, 2018
  29. Yang CF, Ho HL, Lin SC, Hsu CY, Ho DM*. Detection of human cytomegalovirus in glioblastoma among Taiwanese subjects. PLoS One.12(6): e0179366, 2017
  30. Hsu CY, Ho HL, Lin SC, Chen MH, Hsu SP, Yen YS, Guo WY, Ho DM*. Comparative Assessment of 4 Methods to Analyze MGMT Status in a Series of 121 Glioblastoma Patients. Appl Immunohistochem Mol Morphol. 25(7):497-504, 2017
  31. Hsu CY, Ho HL, Lin SC, Ho TD, Ho DM*. The MGMT promoter single-nucleotide polymorphism rs1625649 had prognostic impact on patients with MGMT methylated glioblastoma. PLoS One. 12(10): e0186430, 2017
  32. Chiang CL, Wang LC, Ho HL, Tsai CM, Yeh YC, Hsu WH, Chou TY, Chiu CH*, Wu YC*. Effect of postoperative systemic therapy on pulmonary adenocarcinoma with unexpected pleural spread detected during thoracotomy or thoracoscopy. Oncotarget.9(4):5435-5444, 2017
  33. Yeh YC, Lei HJ, Chen MH, Ho HL, Chiu LY, Li CP, Wang YC*. C-Reactive Protein (CRP) is a Promising Diagnostic Immunohistochemical Marker for Intrahepatic Cholangiocarcinoma and is Associated with Better Prognosis. Am J Surg Pathol. 41(12):1630-1641, 2017
  34. Kao HL, Yeh YC, Lin CH, Hsu WF, Hsieh WY, Ho HL*, Chou TY*. Diagnostic algorithm for detection of targetable driver mutations in lung adenocarcinomas: Comprehensive analyses of 205 cases with immunohistochemistry, real-time PCR and fluorescence in situ hybridization methods. Lung Cancer. 101:40-47, 2016 (*co-corresponding authors)
  35. Kao HL, Lai CR, Ho HL, Pan CC*. Molecular typing for detection of high-risk human papillomavirus is a useful tool for distinguishing primary bladder carcinoma from secondary involvement of uterine cervical carcinoma in the urinary bladder. Histopathology. 68(4):513-9, 2016
  36. Hsu CY, Ho HL, Chang-Chien YC, Chang YW, Ho DM*. MGMT promoter methylation in non-neoplastic brain. J Neurooncol. 121(3):459-467, 2015
  37. Hsu CY, Ho HL, Lin SC, Chang-Chien YC, Chen MH, Hsu SP, Yen YS, Guo WY, Ho DM*. Prognosis of glioblastoma with faint MGMT methylation-specific PCR product. J Neurooncol. 122(1):179-88, 2015
  38. Chiu CH, Ho HL#, Doong H, Yeh YC, Chen MY, Chou TY*, Tsai CM*. MLH1 V384D polymorphism associates with poor response to EGFR tyrosine kinase inhibitors in patients with EGFR L858R-positive lung adenocarcinoma. Oncotarget. 6(10):8407-8417, 2015 (#co-first authors)
  39. Luo YH, Ho HL, Tsai CM, Shih JF, Chiu CH, Lai SL, Lee YC, Perng RP, Whang-Peng J, Chou TY, Chen YM*. The association between tumor epidermal growth factor receptor (EGFR) mutation and multiple primary malignancies in patients with adenocarcinoma of the lungs. Am J Clin Oncol. 38(2):147-51. 2015
  40. Chiu CH, Ho HL#, Chiang CL, Lin SF, Ma HH, Chuang YT, Lin KY, Tsai CM, Chou TY*. Clinical characteristics and treatment outcomes of lung adenocarcinomas with discrepant EGFR mutation testing results derived from PCR-direct sequencing and real-time PCR-based assays. J Thorac Oncol. 9(1):91-6, 2014 (#co-first authors)
  41. Hsu CY, Yang CF, Liao LR, Ho HL, Ho DM*. Tonsil surface epithelium is ideal for monitoring Ki-67 immunohistochemical staining. Histopathology. 63(6):810-816, 2013
  42. Hsu CY, Lin SC, Ho HL, Chang-Chien YC, Hsu SP, Yen YS, Chen MH, Guo WY, Ho DM*. Exclusion of histiocytes/endothelial cells and using endothelial cells as internal reference are crucial for interpretation of MGMT immunohistochemistry in glioblastoma. Am J Surg Pathol 37(2):264-271, 2013
  43. Ho HL, Chang FP, Ma HH, Liao LR, Chuang YT, Chang-Chien YC, Lin KY, Chou TY*. Molecular diagnostic algorithm for epidermal growth factor receptor mutation detection in Asian lung adenocarcinomas: comprehensive analyses of 445 Taiwanese patients with immunohistochemistry, PCR-direct sequencing and Scorpion/ARMS methods. Respirology. 18(8):1261-1270, 2013
  44. Ho HL, Lee HY, Liao HC, Chen MY*. Involvement of Saccharomyces cerevisiae Avo3p/Tsc11p in maintaining TOR complex 2 integrity and coupling to downstream signaling. Eukaryot Cell. 7(8):1328-1343, 2008
  45. Ho HL, Shiau YS, Chen MY*. Saccharomyces cerevisiaeTSC11/AVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex. Curr Genet. 47(5):273-288, 2005
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