臺北榮總癲癇及相關疾病基因研究檢測服務

北榮癲癇科與陽明交大及跨國研究團隊合作發現局部腦皮質發育不全導致癲癇的新穎致病基因FOXJ3

影音:《線上癲癇教室》~劉祐岑醫師線上演講

影音:  破解迷思！憂鬱、便秘也可能是巴金森病前兆

真實世界數據」更貼近病患真實健康狀況，有效反應藥物療效

神經罕見疾病約診連絡電話02-2871-2121 轉 86704 (神經內科腦波室)；手機: 0972-035-675

英文履歷 (CV)

得獎紀錄:

• 2025 (114年) 7月份臺北榮民總醫院教學病歷優良指導醫師
  2024 (113年) 國軍退除役官兵輔導委員會優良醫師。

  2023 (112年)台灣癲癇醫學會研究論文獎第二名。
  2021亞太神經學大會(Asian Oceanian Congress of Neurology)最佳論文及口頭發表。
  2021 (110年)第17屆榮總台灣聯合大學合作研究計畫優良論文第二名。
  2020台灣神經學學會年會論文口頭發表最佳論文及口頭發表。
  2019 (108年)第15屆榮總台灣聯合大學合作研究計畫『優良壁報論文』第一名
  2017第四屆台灣巴金森暨動作障礙疾病研討會(Taiwan International Congress of Parkinson Disease and Movement Disorders)優秀論文。
  2017 (106年)臺北榮民總醫院PGY票選優良教學醫師。
  2017 (106年)台灣動作障礙學會年會優秀論文銅牌獎。
  2017 (106年)年台灣癲癇醫學會研究論文獎第一名。
  國立陽明交通大學醫學系109~112學年優良教師。
  國立陽明大學醫學系優良教師。
  國立陽明大學醫學系PBL引導老師優良教師。

論文著作：*Corresponding author, # equal contribution (selected)

1.  Epilepsy-associated FOXJ3 variants link a transcriptional program of the PTEN-mTOR pathway to neuronal specification and cortical lamination. Cheng HY^#, Liu C^#, Nian CW^$, Huang HC^$, Zhao HJ^$, Nian FS, Chen C, Custodio HM, Sisodiya SM, Lu C, Chen HH, Hsu CS, Pi WC, Chu CC, Hsu JS, Chen PL, Chang FP, Tung CY, Chou SJ, Alavi S, Houlden H, Chen WY, Liu YT*, Hou PS*, and Tsai JW*. Nat Commun. 2026 Mar 9;17(1):1815. doi: 10.1038/s41467-026-69241-2.
2. Knowledge Graph Representation of the Mappings between Seizure Semiology and Epileptogenic Zones. Yanga S, Wenb Z, Zhana W, Fotedarc N, Shih YC, Dinga JE, Bernardof D, Kallioniemig E, Alexandergh W, Huangi X, Rosenowj F, Sunk H, Liu YT^*#, Wul S^*#, and Liu F^*#. Scientific Reports. 2026 Jan 10;16(1):3004. doi: 10.1038/s41598-025-32920-z.
3. Epilepsy-Associated FOXJ3 Variants Link a Novel Transcriptional Program of PTEN-mTOR Pathway to Neuronal Specification and Cortical Lamination. Cheng HY^#, Liu C^#, Nian CW^$, Huang HC^$, Zhao HJ^$, Nian FS, Chen C, Custodio HM, Sisodiya S, Lu C, Chen HH, Hsu CS, Tung CY, Chou SJ, Alavi S, Houlden H, Chen WY, Chu CC, Hsu JS, Chen PL, Chang FP, Liu YT*, Hou PS*, and Tsai JW*. Nature Communications. Accepted in Oct 2025, in press. (SCI)
4. Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort. Wei CY^#, Wen MS^#, Cheng CK^#, Sheen YJ^#, Yao TC^#, Lee SL^#,…YT Liu,…Chen CH*, Chien CC*, Chiang HS*, Chiu YL*, Chen HC*, and Kwok PY*. Nat Commun. 2025 Jul 9;16(1):6344.(SCI)
5. Effects of dual-task training on gait variability in individuals with Parkinson's disease: A randomized controlled trial. Zhou JH, Wang RY, Liu YT, Cheng SJ, Liu HH, Yang YR*. J Sci Med Sport. 2025 Dec;28(12):1012-1018.
6. Relationship Between Executive Function and Dual-Task Walking in People with Parkinson's Disease. Zhou JH, Wang RY, Liu YT, Cheng SJ, Liu HH and Yang YR*. Front Aging Neurosci. 2025 Jun 18;17:1585524. eCollection 2025.(SCI)
7. The structural and dynamic insights into the Ala97ser amyloidogenic mutation in transthyretin. Feng YC, Agrawal S,Yang CH, Chang HC, Kuo L, Yu WC, Liu YT*^# and Yu TY.*^# Chemistry - An Asian Journal, 2024 Dec 12:e202401438. (SCI)

1. Improvement in Executive Function and Dual-task Cost in People With Parkinson Disease: A Randomized Controlled Trial. Zhou JH, Wang RY, Liu YT, Cheng SJ, Liu HH, Yang YR*. J Neurol Phys Ther. 2024 Oct 1;48(4):188-197. Epub 2024 Sep 17. (SCI) ***The winner of the Golden Synapse award as the most outstanding article published in JNPT in 2024.
2. Magnetic resonance radiomics-derived sphericity correlates with seizure in brain arteriovenous malformations. Lin JY, Lu CF, Hu YS, Yang HC, Liu YT, Loo JK, Lee KL, Liao CY, Chang FC, Liou KD, Lin CJ*. Eur Radiol. 2024 Jan;34(1):588-599.(SCI)
3. Monogenic causes in familial stroke across intracerebral hemorrhage and ischemic stroke subtypes identified by whole exome sequencing. Chang LH, Chi NF, Chen CY, Lin YS, Hsu SL, Ysai JY, Hunag HC, Lin CJ, Chung CP, Tung CY, Jeng CJ, Lee YC, Liu YT*^#, Lee IH*^#. Cell Mol Neurobiol. 2023 Aug;43(6):2769-2783.(SCI)
4. Plasma Matrix Metalloproeteinase‑9 Is Associated with Seizure and Angioarchitecture Changes in Brain Arteriovenous Malformations. Liu YT, Lee CC, Chang FC, Liou KD, Lin CC*. Mol Neurobiol. 2022 Oct;59(10):5925-5934.(SCI)
5. Clinical characteristics and long-term outcome of cerebral cavernous malformations-related epilepsy. Shih YC, Chou CC, Peng SJ, Yu HY, Hsu SPC, Lin CF, Lee CC, Yang HC, Chen YC, Kwan SY, Chen C, Wang SJ, Lin CJ, Lirng JF, Shih YH, Yen DJ, Liu YT*. Epilepsia. 2022 Aug;63(8):2056-2067.(SCI)
6. Novel Lissencephaly-Associated DCX Variants in the C-terminal DCX Domain Affect Microtubule Binding and Dynamics. Lin JR^#, Cheng JF^#, Liu YT, Hsu TR, Lin KM, Chen C, Lin CL, Tsai MH, Tsai JW*. Epilepsia. 2022 May;63(5):1253-1265.(SCI)
7. The clinical and imaging features of FLNA positive and negative periventricular nodular heterotopia. Lu YT, Hsu CY, Liu YT, Chang CK, Chuang YC, Lin CJ, Chang KP, Ho CJ, Ng CC, Lim KS, Tsai MH*. Biomed J. 2022 Jun;45(3):542-548.(SCI)
8. Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late onset amyloidosis and neurodegeneration. R B Ibrahim, SY Yeh, KP Lin, F Ricardo, TY Yu, CC Chan, JW Tsai*^#, YT Liu*^#. Cell Mol Life Sci. 2020 Apr;77(7):1421-1434. (SCI)
9. Biophysical characterization and pharmacological modulation of Transthyretin Ala97Ser mutant. YT Liu, YJ Yen, F Ricardo, Y Chang, PH Wu, SJ Huang, KP Lin*, TY Yu*. Ann Clin Transl Neurol. 2019 Oct;6(10):1961-1970.(SCI)
10. Novel SCA19/22-associated KCND3 mutations disrupt human KV4.3 protein biosynthesis and channel gating. Hsiao CT, Fu SJ, Liu YT, Liao YC, Lu YH, Huang JJ, Chien YC, Zhong CY, Tsai PC, Tang CY, Lee YC, Soong BW*, Jeng CJ*. Hum Mutat. 2019 Nov;40(11):2088-2107.
11. PDXK mutations cause polyneuropathy responsive to PLP supplementation. Chelban V, Wilson MP, Warman Chardon J,…Liu YT,… Houlden H*; Care4Rare Canada Consortium; SYNaPS Study Group. Ann Neurol. 2019 Aug;86(2):225-240.
12. Clinical and genetic profiles of hereditary transthyretin amyloidosis in Taiwan. Chao HC, Liao YC, Liu YT, Guo YC, Chang FP, Lee YC*, Lin KP*. Ann Clin Transl Neurol. 2019 Apr 9;6(5):913-922. (SCI)
13. PRRT2 Missense Mutations Cluster near C-terminus and Frequently Lead to Protein Mislocalization. Tsai MH, Nian FS, Hsu MH, Liu WS, Liu YT, Liu C, Lin PH, Hwang DY, Chuang YC, Tsai JW*. Epilepsia. 2019 May;60(5):807-817. (SCI)
14. Contributions of Animal Models to the Mechanisms and Therapies of Transthyretin Amyloidosis. Ibrahim RB, Liu YT, Yeh SY, Tsai JW. Front Physiol. 2019 Apr 2;10:338. doi: 10.3389/fphys.2019.00338. eCollection 2019. Review. (SCI)
15. Aberrant sensory gating of the primary somatosensory cortex contributes to the motor circuit dysfunction in paroxysmal kinesigenic dyskinesia. Liu YT, Chen YC, Kwan SY, Chou CC, Yu HY, Yen DJ, Liao KK, Chen WT, Lin YY, Chen RS, Jih KY, Lu SF, Wu YT, Wang PS, Hsiao FJ*. Front Neurol. 2018 Oct 15;9:831. (SCI)
16. Clinical and Biophysical Characterization of Nineteen GJB1 Mutations. Tsai PC, Yang DM, Liao YC, Chiu YU, Kuo HC, Su YP, Guo YC, Soong BW, Lin KP, Liu YT*, Lee YC*. Ann Clin Transl Neurol. 2016 Sep 1;3(11):854-865.
17. PRRT2 mutations lead to neuronal dysfunction and neurodevelopmental defects. Liu YT, Nian FS, Chou WJ, Tai CY, Kwan SY, Chen C, Kuo PW, Lin PH, Chen CY, Lee YC, Soong BW*, Tsai JW*. Oncotarget. 2016 Jun 28;7(26):39184-39196.
18. Transthyretin Ala97Ser in Chinese-Taiwanese patients with familial amyloid polyneuropathy: genetic studies and phenotype expression. Liu YT, Lee YC, Yang CC, Chen ML, Lin KP. J Neurol Sci. 2008 Apr 15;267(1-2):91-9. (SCI)