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Ching-Mao Chang (張清貿)

Ching-Mao Chang(張清貿)

簡介

學歷
  1. 長庚大學臨床醫學研究所醫學博士 臨床醫學 醫學博士 (2017)
  2. 中國醫藥大學中醫學系中醫學士 中醫 學士
經歷 現職:
  1. - 迄今 臺北榮民總醫院 傳統醫學部 主治醫師
  2. - 迄今 國立陽明大學 醫學系 助理教授
經歷:
  1. - 塔夫茨醫學中心 風濕免疫科/補充與整合醫學中心 訪問研究學者
  2. - 臺北榮民總醫院 傳統醫學部 總醫師
  3. - 臺北榮民總醫院 傳統醫學部 住院醫師
醫療專長
  1. 自體免疫風濕疾病、修格蘭氏症/乾燥症、紅斑性狼瘡、類風濕關節炎、失眠、憂鬱、胃食道逆流、免疫性不孕、過敏性鼻炎、針刺
證照
  1. 中華民國中醫師執照

著作

Representative works (in English):

  1. Ching-Mao Chang, Hsueh-Ting Chu, Yau-Huei Wei, Fang-Pey Chen, Shengwen Wang, Po-Chang Wu, Hung-Rong Yen, Tzeng-Ji Chen* and Hen-Hong Chang*The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren's syndrome: A Nationwide Population-Based StudyScientific Reports. 2015 (SCI, 2014 IF= 5.578) 
  2. Hen-Hong Chang, Shue-Fen Luo, Yin-Tzu Hsue, Ching-Mao Chang, Tzung-Yan Lee, Ming-Ling Hsu, Yu-Chuen Huang, Yu-Jen Chen. Modulation of Endothelial Injury Biomarkers by Traditional Chinese Medicine LC in Systemic Lupus Erythematosus Patients Receiving Standard Treatments. Scientific Reports. 2016 (SCI, 2015 IF=5.578)
  3. Ching-Mao Chang, Po-Chang Wu, Jen-Huai Chiang, Yau-Huei Wei, Fang-Pey Chen, Tzeng-Ji Chen, Tai-Long Pan, Hung-Rong Yen* and Hen-Hong Chang*. Integrative therapy decreases the risk of lupus nephritis in patients with systemic lupus erythematosus: A population-based retrospective cohort study. Journal of Ethnopharmacology. 2017 (SCI, 2015 IF= 3.055)
  4. Pei-Wen Wu#, Po-Hsuan Shih#, Yen-Ying Kung, Fang-Pey Chen, Ching-Mao Chang*Integrated Therapy Improve Urinary Total Protein in Patients with Lupus Nephritis: A Case ReportComplementary Therapies in Medicine. 2018 (SCI, 2016 IF= 2.013)
  5. Ching-Mao Chang#, Po-Hsuan Shih#, Tzeng-Ji Chen, Wen-Chao Ho*, Chun-Pai Yang*. Integrated Therapy Decreases the Mortality of Patients with Polymyositis and Dermatomyositis: A Taiwan-wide Population-Based Retrospective Study. Journal of Ethnopharmacology. 2019, 236: 70-81 (SCI, 2018 IF= 3.414)

 

Representative works (in Chinese):

  1. 張清貿, 施柏瑄, 楊仕哲*. 心腦主神明學說的沿革中醫藥雜誌. 2017, 28(1): 2801001
  2. 施柏瑄#, 洪國棟#, 林奕中, 張清貿*僵直性脊椎炎之中醫藥文獻回顧中醫藥研究論叢. 2016, 19(2):99-112
  3. 張清貿, 施柏瑄, 朱學亭, 陳方佩. 該如何理解「證」?- 中醫證型現代研究的定性與定量臨床醫學. 2014 (73):189-195
  4. 張清貿, 侯庭鏞, 朱學亭, 李佳橙, 張永賢* 附子在溫經散寒及清熱瀉火劑之數學模式表現 (A mathematical method to differentiate the effects of “Aconitum carmichaeli Debx” in different prescriptions)Mid-Taiwan Journal of Medicine. 2008 13(3): 152-157
  5. [專欄採訪] 2017 榮總人 394 -科學化現代醫學語言證實中藥改善眼乾口渴-臺北榮民總醫院傳統醫學部張清貿主治醫師
  6. [食譜] #史上最強!水波爐脫油減鹽料理117# - 「涼補醬燒雞」藥膳料理,由臺北榮民總醫院張清貿醫師及振興醫院中醫科施柏瑄醫師提供

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[臨床病例報告] 

中西醫整合治療紅斑性狼瘡腎炎病例報告

題目:Integrated Therapy Improve Urinary Total Protein in Patients with Lupus Nephritis: A Case Report
期刊:Complementary Therapies in Medicine
 

本病例是一位55歲女性,自民國89年確診為紅斑性狼瘡(Systemic Lupus Erythematosus, SLE),接受口服類固醇治療,規律追蹤至民國105年初,開始出現雙小腿水腫,抽筋,反覆泌尿道感染,以及小便伴隨泡沫,經風濕免疫科診斷為狼瘡性腎炎(Lupus Nephritis, LN),患者服用西藥同時併用中醫藥治療,有效改善水腫以及24小時尿液蛋白(Urine Total Protein, M-TP)明顯減少,從1367.9 mg/24 h 減少至 143.6 mg/24 h.,病情趨於好轉。

這是我第一篇投稿國際SCI期刊的Systemic Lupus Erythematosus 紅斑性狼瘡病例報告,也是我指導學生完成的第一篇PAPER,這幾天正式獲國際期刊接受並刊出。

中醫藥治療腎炎很困難,治療免疫性疾病造成的腎炎更是困難。

雖然只是一篇小小的病例報告,但其實讓我想起我剛念碩士班的時候,一開始是做過敏性鼻炎,後來被張恒鴻指導教授指派去接手SLE-LC複方中醫藥臨床試驗,然後試驗完成才開始正式進行博士班修格蘭氏症中醫藥臨床試驗。

因為指導教授安排我回去幫大學生上課,主題為「大學生如何進行中醫專題研究」,讓我回顧了這10年來我到底在幹麻?沒想到我SLE還做了不少,從SLE問卷一致度、中藥改善狼瘡性腎炎資料庫、LC複方改善SLE患者血管內皮細胞,到這一篇的中西醫整合治療紅斑性狼瘡腎炎病例報告

最近回顧發現,
1.Systemic Lupus Erythematosus 紅斑性狼瘡研究進行了:資料庫、臨床試驗、臨床病例報告
2.Sjögren's syndrome 修格蘭氏症研究進行了:資料庫、臨床試驗

不管是Systemic Lupus Erythematosus 紅斑性狼瘡還是Sjögren's syndrome 修格蘭氏症研究,都從資料庫一直做到臨床,一直朝著我的理想中研究邁進,也能夠將研究轉譯轉化為臨床回饋給患者,再從臨床患者轉饋回研究,相輔相成。

非常感謝各位受試者和臨床門診患者的支持與鼓勵,希望能持續努力,為中醫藥實證醫學與中醫藥治療風濕免疫疾病能墊上一塊磚!
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https://www.sciencedirect.com/science/article/pii/S0965229918301948
Complementary Therapies in Medicine. 2018 
Integrated Therapy Improve Urinary Total Protein in Patients with Lupus Nephritis: A Case Report

Pei-Wen Wu, Po-Hsuan Shih, Yen-Ying Kung, Fang-Pey Chen, Ching-Mao Chang*


Objectives
To report on the potential effectiveness of Chinese herbal medicine (CHM) as part of an integrated treatment for lupus nephritis.

Clinical features and outcome
A 55-year-old female with systemic lupus erythematosus had experienced bilateral lower-limbs edema for half a year. Her urinary total protein (M-TP) was 1367.9 mg/24 h. Lupus nephritis (LN) was suspected by the Division of Rheumatology without a renal biopsy. Oral corticosteroid medication did not improve the edema; therefore, the patient requested CHM for integrated therapy, and was subsequently treated for seven months with a modified CHM prescription mainly composed of Zhi-Bo-Di-Huang-Wan, Gui-Shao-Zhi-Mu-Tang, and Zhu-Ling-TangAfter three days of CHM, her bilateral lower-limbs edema significantly improved, and after 143 days, her M-TP decreased from 1367.9 mg/24 h to 143.6 mg/24 h.

Conclusions
Integrated therapy could significantly improve proteinuria by reducing this LN patients’ urinary total protein, which further implies that CHM may have a protective effect against the progression of LN in this patient.