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Chang-Phone Fung (馮長風)

Chang-Phone Fung(馮長風)

簡介

學歷
  1. 國立台灣大學醫學系醫學士
  2. 英國倫敦大學醫用微生物研究所碩士
經歷 現職:
  1. - 迄今 臺北榮民總醫院 內科部感染科 特約醫師
經歷:
  1. - 國立陽明大學急重症醫學研究所 專任教授
  2. - 臺北榮民總醫院 內科部 住院醫師
  3. - 臺北榮民總醫院 內科部 總醫師
  4. - 國立陽明大學 醫學系 兼任講師
  5. - 臺北榮民總醫院 內科部感染科 主治醫師
  6. - 中華民國感染症醫學會秘書長
  7. - 微免與感染雜誌經理編輯
  8. - 國立陽明大學 醫學系 兼任副教授
  9. - 國家衛生研究院 臨床研究組 兼任副研究員
  10. - 國立陽明大學 熱帶醫學研究所 專任副教授
  11. - 竹東榮民醫院 副院長
  12. - 臺北榮民總醫院 內科部感染科 主任
醫療專長
  1. 感染症學、臨床微生物學及其致病機轉、分子生物學、細菌抗藥性的研究、院內感染
證照
  1. 中華民國感染症專科醫師
  2. 中華民國內科專科醫師
語言專長
  1. 國語 台語 英語

著作

2014

  1. Liu EY, Chang FY, Chang JC, Fung CP*. Differences in virulence of pneumolysin and autolysin mutants constructed by insertion duplication mutagenesis and in-frame deletion in Streptococcus pneumoniae. BMC Biotechnol. 2014 Feb 21;14:16. doi: 10.1186/1472-6750-14-16.
  2. Lin YT, Tseng KY, Yeh YC, Yang FC, Fung CP*, Chen NJ. TREM-1 promotes survival during Klebsiella pneumoniae liver abscess in mice.  Infect Immun. 2014 Mar;82(3):1335-42.
  3. Wu YY, Hsu CM, Chen PH, Fung CP, Chen LW*. Toll-like receptor stimulation induces nondefensin protein expression and reverses antibiotic-induced gut defense impairment. Infect Immun. 2014 May;82(5):1994-2005

 

2013

  1. Cheng A, Fung CP#, Liu CC, Lin YT, Tsai HY, Chang SC, Chou AH, Chang JY, Jiang RH, Hsieh YC, Su IJ, Chong PC, Hsieh SM. A Phase I, randomized, open-label study to evaluate the safety and immunogenicity of an enterovirus 71 vaccine. Vaccine. 2013;31(20):2471-6.(#Co-first author)
  2. Lin YT, Liu CJ, Yeh YC, Chen TJ, Fung CP*. Ampicillin and Amoxicillin Use and the Risk of Klebsiella pneumoniae Liver Abscess in Taiwan.  J Infect Dis. 2013 May 2. [Epub ahead of print]
  3. Yang SP, Chen YY, Hsu HS, Wang FD, Chen LY, Fung CP*. A risk factor analysis of healthcare-associated fungal infections in an intensive care unit: a retrospective cohort study. BMC Infect Dis. 2013;13:10. Epub 2013/01/10(*Coresponding author)
  4. Lin YT, Wang FD, Wu PF, Fung CP. Klebsiella pneumoniae liver abscess in diabetic patients: association of glycemic control with the clinical characteristics. BMC Infect Dis. 2013;13:56. Epub 2013/02/01.
  5. Chi CY, Chu CC, Liu JP, Lin CH, Ho MW, Lo WJ, Lin PC, Chen HJ, Chou CH, Feng JY, Fung CP, et al. Anti-IFN-gamma autoantibodies in adults with disseminated nontuberculous mycobacterial infections are associated with HLA-DRB1*16:02 and HLA-DQB1*05:02 and the reactivation of latent varicella-zoster virus infection. Blood. 2013;121(8):1357-66. Epub 2012/12/18.

 

2012

  1. Fung CP*, Lin YT, Lin JC, Chen TL, Yeh KM, Chang FY, et al. Klebsiella pneumoniae in gastrointestinal tract and pyogenic liver abscess. Emerg Infect Dis. 2012;18(8):1322-5.
  2. Yeh FC, Yeh KM, Siu LK, Fung CP, Yang YS, Lin JC, et al. Increasing opsonizing and killing effect of serum from patients with recurrent K1 Klebsiella pneumoniae liver abscess. J Microbiol Immunol Infect. 2012;45(2):141-6. Epub 2012/03/27.
  3. Wu HS, Wang FD, Tseng CP, Wu TH, Lin YT, Fung CP. Characteristics of healthcare-associated and community-acquired Klebsiella pneumoniae bacteremia in Taiwan. J Infect. 2012;64(2):162-8. Epub 2011/11/22.
  4. Wu HS, Kuo SC, Lee YT, Yang YS, Cheng SS, Chen TL, Fung CP. Clinical characteristics and prognostic factors of Acinetobacter nosocomialis bacteraemia in patients with solid tumours. Clin Microbiol Infect. 2012;18(9):E373-6.
  5. Wu HS, Kuo SC, Chen LY, Chiang MC, Lin YT, Wang FD, Fung CP. Comparison between patients under hemodialysis with community-onset bacteremia caused by community-associated and healthcare-associated methicillin-resistant Staphylococcus aureus strains. J Microbiol Immunol Infect. 2012. Epub 2012/04/24.
  6. Wang YP, Liu CJ, Hu YW, Chen TJ, Lin YT, Fung CP. Risk of cancer among patients with herpes zoster infection: a population-based study. CMAJ. 2012;184(15):E804-9.
  7. Tseng CP, Wu HS, Wu TH, Lin YT, Fung CP. Clinical characteristics and outcome of patients with community-onset Klebsiella pneumoniae bacteremia requiring intensive care. J Microbiol Immunol Infect. 2012. Epub 2012/07/27.
  8. Siu LK, Yeh KM, Lin JC, Fung CP, Chang FY. Klebsiella pneumoniae liver abscess: a new invasive syndrome. Lancet Infect Dis. 2012;12(11):881-7.
  9. Liu YH, Kuo SC, Lee YT, Chang IC, Yang SP, Chen TL, Fung CP. Amino acid substitutions of quinolone resistance determining regions in GyrA and ParC associated with quinolone resistance in Acinetobacter baumannii and Acinetobacter genomic species 13TU. J Microbiol Immunol Infect. 2012;45(2):108-12.
  10. Lin YT, Siu LK, Lin JC, Chen TL, Tseng CP, Yeh KM, Chang FY, Fung CP*. Seroepidemiology of Klebsiella pneumoniae colonizing the intestinal tract of healthy Chinese and overseas Chinese adults in Asian countries. BMC Microbiol. 2012;12:13. Epub 2012/01/21.
  11. Lin YT, Liu CJ, Chen TJ, Fung CP*. Long-term mortality of patients with septic ocular or central nervous system complications from pyogenic liver abscess: a population-based study. PloS One. 2012;7(3):e33978. Epub 2012/04/06.
  12. Lin YT, Fung CP*. Pyogenic liver abscess in the elderly: what we have learned? J Chin Med Assoc. 2012;75(4):139-40.
  13. Lee YT, Kuo SC, Yang SP, Lin YT, Tseng FC, Chen TL, Fung CP. Impact of appropriate antimicrobial therapy on mortality associated with Acinetobacter baumannii bacteremia: relation to severity of infection. Clin Infect Dis. 2012;55(2):209-15.
  14. Lee YT, Kuo SC, Yang SP, Lin YT, Chiang DH, Tseng FC, Chen TL, Fung CP. Bacteremic nosocomial pneumonia caused by Acinetobacter baumannii and Acinetobacter nosocomialis: a single or two distinct clinical entities? Clin Microbiol Infect. 2012. Epub 2012/09/13.
  15. Lee YT, Kuo SC, Chiang MC, Yang SP, Chen CP, Chen TL, Fung CP. Emergence of carbapenem-resistant non-baumannii species of Acinetobacter harboring a blaOXA-51-like gene that is intrinsic to A. baumannii. Antimicrob Agents Chemother. 2012;56(2):1124-7.
  16. Kuo SC, Lee YT, Yang SP, Chen CP, Chen TL, Hsieh SL, Siu LK, Fung CP. Eradication of multidrug-resistant Acinetobacter baumannii from the respiratory tract with inhaled colistin methanesulfonate: a matched case-control study. Clin Microbiol Infect. 2012;18(9):870-6.
  17. Kuo SC, Chiang MC, Lee WS, Chen LY, Wu HS, Yu KW, Fung CP,et al. Comparison of microbiological and clinical characteristics based on SCCmec typing in patients with community-onset meticillin-resistant Staphylococcus aureus (MRSA) bacteraemia. Int J Antimicrob Agents. 2012;39(1):22-6.
  18. Huang ST, Chiang MC, Kuo SC, Lee YT, Chiang TH, Yang SP, Ti-Yin, Chen TL, Fung CP. Risk factors and clinical outcomes of patients with carbapenem-resistant Acinetobacter baumannii bacteremia. J Microbiol Immunol Infect. 2012;45(5):356-62.
  19. Hsu SF, Lin YT, Chen TL, Siu LK, Hsueh PR, Huang ST, Fung CP*. Antimicrobial resistance of Moraxella catarrhalis isolates in Taiwan.  J Microbiol Immunol Infect. 2012;45(2):134-40.
  20. Chiang MC, Kuo SC, Chen SJ, Yang SP, Lee YT, Chen TL, Fung CP. Clinical characteristics and outcomes of bacteremia due to different genomic species of Acinetobacter baumannii complex in patients with solid tumors. Infection. 2012;40(1):19-26.

 

2011

  1. Fung CP*, Chang FY, Lin JC, Ho DM, Chen CT, Chen JH, Yeh KM, Chen TL, Lin YT, Siu LK. Immune response and pathophysiological features of Klebsiella pneumoniae liver abscesses in an animal model. Lab Invest. 2011 Jul;91(7):1029-39.
  2. Tsai YK, Fung CP*, Lin JC, Chen JH, Chang FY, Chen TL, et al. Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence. Antimicrob Agents Chemother. 2011;55(4):1485-93. (*Coresponding author)
  3. Siu LK, Fung CP, Chang FY, Lee N, Yeh KM, Koh TH, Ip M. Molecular typing and virulence analysis of serotype K1 Klebsiella pneumoniae strains isolated from liver abscess patients and stool samples from noninfectious subjects in Hong Kong, Singapore, and Taiwan. J Clin Microbiol. 2011;49(11):3761-5.
  4. Tseng CY, Chen CH, Su SC, Wu FT, Chen CC, Hsieh GY, Hung CH, Fung CP*. Characteristics of norovirus gastroenteritis outbreaks in a psychiatric centre. Epidemiol Infect. 2011;139(2):275-85.
  5. Lee YT, Chen TL, Siu LK, Chen CP, Fung CP*. Impact of derepressed AmpC beta-lactamase ACT-9 on the clinical efficacy of ertapenem. Antimicrob Agents Chemother. 2011;55(9):4440-2.
  6. Chen TL, Fung CP, Lee SD. Spontaneous eradication of a NDM-1 positive Klebsiella pneumoniae that colonized the intestine of an asymptomatic carrier. J Chin Med Assoc. 2011;74(2):104.
  7. Lin YT, Liu CJ, Fung CP*, Tzeng CH. Nosocomial Klebsiella pneumoniae bacteraemia in adult cancer patients-characteristics of neutropenic and non-neutropenic patients. Scand J Infect Dis. 2011;43(8):603-8. 
  8. Wang FD, Chen YY, Chen TL, Lin YT, Fung CP. Risk factors and mortality of nosocomial infections of methicillin-resistant Staphylococcus aureus in an intensive care unit. J Crit Care. 2011;26(1):82-8.
  9. Lee YT, Chen TL, Lin YC, Fung CP, Cho WL. Nosocomial nasal myiasis in an intubated patient. J Chin Med Assoc. 2011;74(8):369-71.
  10. Kuo SC, Wang FD, Fung CP, Chen LY, Chen SJ, Chiang MC, et al. Clinical experience with tigecycline as treatment for serious infections in elderly and critically ill patients. J Microbiol Immunol Infect. 2011;44(1):45-51.
  11. Chiu CH, Yeh KM, Siu LK, Fung CP, Lin JC, Chang FY. Impact of age on neutrophil phagocytic reaction with different capsular serotypes of Klebsiella pneumoniae. J Microbiol Immunol Infect. 2011;44(5):333-7..
  12. Chiang MC, Kuo SC, Chen YC, Lee YT, Chen TL, Fung CP. Polymerase chain reaction assay for the detection of Acinetobacter baumannii in endotracheal aspirates from patients in the intensive care unit. J Microbiol Immunol Infect. 2011;44(2):106-10.
  13. Chen SJ, Chao TF, Chiang MC, Kuo SC, Chen LY, Chiang DH, Yin T, Chen TL, Fung CP. Predictors of mortality in surgical patients with Acinetobacter baumannii bacteremia. J Microbiol Immunol Infect. 2011;44(3):209-14.
  14. Chen LY, Liao SY, Kuo SC, Chen SJ, Chen YY, Wang FD, Yang SP, Fung CP. Changes in the incidence of candidaemia during 2000-2008 in a tertiary medical centre in northern Taiwan. J Hosp Infect. 2011;78(1):50-3.
  15. Chen LY, Huang CH, Kuo SC, Hsiao CY, Lin ML, Wang FD, Fung CP. High-dose daptomycin and fosfomycin treatment of a patient with endocarditis caused by daptomycin-nonsusceptible Staphylococcus aureus: case report. BMC Infect Dis. 2011;11:152. Epub 2011/05/27.

 

2010

  1. Chen TL, Lee YT, Kuo SC, Hsueh PR, Chang FY, Siu LK, Ko WC, Fung CP*. Emergence and distribution of plasmids bearing the ISAba1-blaoxa-51-like gene in carbapenem resistant Acinetobacter baumannii in Taiwan. Antimicrob Agents Chemother. 2010;54(11):4575-81. 
  2. Lin YT, Chen TL, Siu LK, Hsu SF, Fung CP*. Clinical and microbiological characteristics of community-acquired thoracic empyema or complicated parapneumonic effusion caused by Klebsiella pneumoniae in Taiwan. Eur J Clin Microbiol Infect Dis. 2010;29(8):1003-10.
  3. Lin YT, Jeng YY, Chen TL, Fung CP*. Bacteremic community-acquired pneumonia due to Klebsiella pneumoniae: clinical and microbiological characteristics in Taiwan, 2001-2008. BMC Infect Dis. 2010;10:307.
  4. Chen TL, Chang WC, Kuo SC, Lee YT, Chen CP, Siu LK, Cho WL, Fung CP*. Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in Acinetobacter genomic species 13TU.Antimicrob Agents Chemother. 2010;54(8):3107-12.
  5. Chiang MC, Chiang FC, Chang YT, Chen TL, Fung CP. Erythema multiforme caused by Treponema pallidum in a young patient with human immunodeficiency virus infection. J Clin Microbiol. 2010; 48:2640-2.
  6. Chen SJ, Yang SP, Hung CC, Fung CP. Abacavir-induced agranulocytosis in two Taiwanese patients tested HLA-B*5701-negative. AIDS. 2010; 24:1238-9.
  7. Wu CC, Huang YJ, Fung CP, Peng HL. Regulation of the Klebsiella pneumoniae Kpc fimbriae by the site-specific recombinase KpcI. Microbiology-SGM. 2010; 156:1983-92.
  8. Huang LY, Lu PL, Chen TL, Chang FY, Fung CP, Siu LK. Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. Antimicrob Agents Chemother. 2010;54:2699-703.
  9. Chen JH, Siu LK, Fung CP, Lin JC, Yeh KM, Chen TL, et al. Contribution of outer membrane protein K36 to antimicrobial resistance and virulence in Klebsiella pneumoniae. J Antimicrob Chemother. 2010;65:986-90.
  10. Yeh KM, Lin JC, Yin FY, Fung CP, Hung HC, Siu LK, et al. Revisiting the importance of virulence determinant magA and its surrounding genes in Klebsiella pneumoniae causing pyogenic liver abscesses: exact role in serotype K1 capsule formation. J Infect Dis. 2010;201:1259-67.
  11. Kuo SC, Fung CP, Lee YT, Chen CP, Chen TL. Bacteremia due to Acinetobacter genomic species 10. J Clin Microbiol. 2010;48(2):586-90.
  12. Chan YJ, Lee CL, Hwang SJ, Fung CP, Wang FD, Yen DH, et al. Seroprevalence of antibodies to pandemic (H1N1) 2009 influenza virus among hospital staff in a medical center in Taiwan. J Chin Med Assoc. 2010;73:62-6.
  13. Lin JC, Chang FY, Fung CP, Yeh KM, Chen CT, Tsai YK, et al. Do neutrophils play a role in establishing liver abscesses and distant metastases caused by Klebsiella pneumoniae? PloS One. 2010;5(11):e15005. Epub 2010/12/15.

 

2009

  1. Chuang HC, Chen TL, Chiang DH, Lee YT, Huang LJ, Wang FD, Fung CP*, et al. Clinical and bacteriological characteristics of pyogenic liver abscess in non-diabetic patients. J Microbiol Immunol Infect. 2009 ;42(5):385-92.
  2. Yang YS, Siu LK, Yeh KM, Fung CP, Huang SJ, Hung HC, et al. Recurrent Klebsiella pneumoniae liver abscess: clinical and microbiological characteristics. J Clin Microbiol. 2009;47:3336-9.
  3. Wu KM, Li LH, Yan JJ, Tsao N, Liao TL, Tsai HC, Fung CP, et al. Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis. J Bacteriol. 2009;191:4492-501.
  4. Lee YT, Turton JF, Chen TL, Wu RC, Chang WC, Fung CP, et al. First identification of blaOXA-51-like in non-baumannii Acinetobacter spp. J Chemother. 2009;21:514-20.
  5. Lee YT, Huang LY, Chiang DH, Chen CP, Chen TL, Wang FD, Fung CP, et al. Differences in phenotypic and genotypic characteristics among imipenem-non-susceptible Acinetobacter isolates belonging to different genomic species in Taiwan. Int J Antimicrob Agents. 2009;34:580-4.
  6. Shu HY, Fung CP, Liu YM, Wu KM, Chen YT, Li LH, et al. Genetic diversity of capsular polysaccharide biosynthesis in Klebsiella pneumoniae clinical isolates. Microbiology-SGM. 2009;155:4170-83.
  7. Kang SC, Hsu NW, Tang GJ, Hwang SJ, Fung CP. Adult liver abscess: characteristics of patients living in rural north-eastern Taiwan. Int J Clin Pract. 2009;63(6):949-53.
  8. Ma L, Lin CJ, Chen JH, Fung CP, Chang FY, Lai YK, et al. Widespread dissemination of aminoglycoside resistance genes armA and rmtB in Klebsiella pneumoniae isolates in Taiwan producing CTX-M-type extended-spectrum beta-lactamases. Antimicrob Agents Chemother. 2009;53:104-11.
  9. Lee YT, Huang LY, Chen TL, Siu LK, Fung CP, Cho WL, et al. Gene cassette arrays, antibiotic susceptibilities, and clinical characteristics of Acinetobacter baumannii bacteremic strains harboring class 1 integrons. J Microbiol Immunol Infect. 2009;42:210-9.
  10. Lee SC, Lo HJ, Fung CP, Lee N, See LC. Disk diffusion test and E-test with enriched Mueller-Hinton agar for determining susceptibility of Candida species to voriconazole and fluconazole. J Microbiol Immunol Infect. 2009;42:148-53.
  11. Hung YT, Lee YT, Huang LJ, Chen TL, Yu KW, Fung CP, et al. Clinical characteristics of patients with Acinetobacter junii infection. J Microbiol Immunol Infect. 2009;42:47-53.