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蔡長祐 (Chang-Youh Tsai)


  • 學歷
    國立陽明大學 臨床醫學研究所 博士
    台灣大學 醫學系
  • 經歷
    • - 迄今 財團法人風濕病基金會台灣抗風濕病聯盟 執行長
    • - 迄今 臺北榮總過敏免疫風濕科 科主任
    • - 迄今 國立陽明大學醫學院醫學系 教授
    • - 英國風濕病雜誌編輯委員 編輯委員
  • 醫療專長
    1. 紅斑性狼瘡
    2. 類風濕性關節炎
    3. 高尿酸血症及痛風性關節炎
    4. 僵直性脊椎炎
    5. 自體免疫結締組織疾病
  • 證照
    台灣醫師執照 內科專科醫師 風濕專科醫師 過敏免疫科專科
  • 語言專長
    國語、台語、英語 國語、台語、英語


1. Chang YS, Liu CJ, Chen WS, Lai CC, Wang SH, Chen TJ, Tzeng CH, Tsai CY, Wang SJ. Increased risk of subarachnoid hemorrhage in patients with systemic lupus erythematosus: a nationwide population-based study. Arthritis Care Res 2013;65:601-6. (doi: 10.1002/acr.21846). (SCI)
2. Chang YS, Liu CJ, Wu TH, Chao CH, Lin KC, Ou SM, Chen TJ, Chen WS, Chou CT, Tsai CY*. Survival analysis in systemic lupus erythematosus patients on maintenance dialysis: a nation-wide population-based study in Taiwan. Rheumatology 2013;52:162-72. (doi: 10.1093/rheumatology/kes325) (SCI).
3. Chen CY, Tsai CY, Lee PC, Lee SD. Long-term etanercept therapy favors weight gain and ameliorates cachexia in rheumatoid arthritis patients: roles of gut hormones and leptin. Curr Pharm Desig 2013;19:1956-64. (SCI)
4. Wang SH, Tsai CY, Chang YS, Chen WS, Chou CT. Rituximab therapy in Chinese patients with lupus nephritis. Formos J Rheumatol 2013;27:41-6.
5. Chen CH, Chen HA, Lu CL, Liao HT, Liu CH, Tsai CY, Chou CT. Association of cigarette smoking with Chinese ankylosing spondylitis patients in Taiwan: a poor disease outcome in systemic inflammation, functional ability, and physical mobility. Clin Rheumatol 2013;32:659-63. (SCI)
6. Chen YJ, Wu HH, Liau WT, Tsai CY, Tsai HW, Chao KC, Sung YJ, Li HY. A tumor necrosis factor-alpha inhibitor reduces the embryotoxic effects of endometriotic peritoneal fluid. Fertil Steril 2013;100:1476-85. (SCI) 
7. Chou CT, Chen WS, Chang YS, Lai CC, Wang SH, Chen MH, Tsai CY, Hsiao KH, Lee HT. The serum levels of adipocytokines (leptin, adiponectin and resistin) in ankylosing spondylitis patients. Ann Rheum Dis 2013;71(Suppl 3):648. doi:10.1136/annrheumdis-2012-eular.188 (in abstract) (SCI)
8. Chen CY, Tsai CY*. From endocrine to rheumatism: Do gut hormones play roles in rheumatoid arthritis? Rheumatology 2014;53:205-12. (doi:10.1093/rheumatology/ket255). (SCI) 
9. Li KJ, Siao SC, Wu CH, Shen CY, Wu TH, Tsai CY, Hsieh SC, Yu CL. EGF-like domains in the Tamm-Horsfall glycoprotein core enhance PMN phagocytosis via Rho family and MAPK signaling pathways. Molecules 2014;19:1328-43. (SCI)
10. Lee HT, Lin CS, Lee CS, Wei YH*, Tsai CY*. Increased 8-hydroxy-2’-deoxyguanosine in plasma and decreased mRNA expression of human 8-oxoguanine DNA glycosylase 1, antioxidant enzymes, mitochondrial biogenesis-related proteins and glycolytic enzymes in leukocytes in patients with systemic lupus erythematosus. Clin Exp Immunol 2014;176:66-77. doi: 10.1111/cei.12256 (SCI)
11. Lai CC, Chen WS, Chang DM, Tsao YP, Wu TH, Chou CT, Tsai CY*. Increased serum fibroblast growth factor-23 and decreased bone turnover in patients with systemic lupus erythematosus under treatment with cyclosporine and steroid but not steroid only. Osteoporosis Int 2015;26:601-10. doi: 10.1007/s00198-014-2910-3 (SCI)
12. Chen CH, Chen HA, Liao HT, L u CH, Tsai CY, Chou CT. The clinical usefulness of ESR, CRP, and disease duration in ankylosing spondylitis: the product of these acute-phase reactants and disease duration is associated with patient’s poor physical mobility. Rheumatol Int 2015;35:1263–7. doi: 10.1007/s00296-015-3214-4. (SCI)
13. Lee HT, Lin CS, Lee CS, Tsai CY*, Wei YH*. The role of hOGG1 C1245G polymorphism in the susceptibility of lupus nephritis and modulation of the plasma 8-OHdG in patients with systemic lupus erythematosus. Int J Mol Sci 2015;16:3757-68. doi:10.3390/ijms16023757 (SCI)
14. Chen MH, Chen MH, Tsai CY, Chou CT, Lin HY, Huang DF, Huang YH. Incidence and antiviral response of hepatitis C virus reactivation in lupus patients undergoing immunosuppressive therapy. Lupus 2015;24:1029-36. doi: 10.1177/0961203315571465. (SCI)
15. Chen MH, Chen HA, Chen WS, Chen MH, Tsai CY*, Chou CT*. Upregulation of BMP-2 expression in peripheral-blood mononuclear cells by proinflammatory cytokines and radiographic progression in ankylosing spondylitis. Mod Rheumatol 2015;25:913-9. doi: 10.3109/14397595.2015.1029221. (SCI)
16. Hong JY, Chang YS, Chou CT, Tsai CY, Chen WS. Calcium pyrophosphate deposition pseudoabscess. J Clin Rheumatol 2015;21:270. doi: 10.1097/RHU.0000000000000267. (SCI)
17. Wu CH, Li KJ, Yu CL, Tsai CY, Hsieh SC. Sjögren's Syndrome Antigen B acts as an endogenous danger molecule to induce interleukin-8 gene expression in polymorphonuclear neutrophils. PLoS One 2015;10:e0125501. doi: 10.1371/journal.pone.0125501. (SCI)
18. Tsao YP, Chen CY, Tsai CY, Chang DM. Etanercept injection decreases plasma nitrotyrosine and increases plasma MCP-1 in patients with rheumatoid arthritis. Ann Rheum Dis 2015;74(Suppl 2):1040. doi: 10.1136/annrheumdis-2015-eular.5601 (in abstract) (SCI)
19. Tsao YP, Tsai CY, Chen WS. Image in Rheumatology: Maffucci syndrome. J Rheumatol 2015;42:2434-5. doi: 10.3899/jrheum.150216 (SCI)
20. Liao HT, Lin YF, Tsai CY, Chou CT. Regulatory T cells in ankylosing spondylitis and the response after adalimumab treatment. Bone Joint Spine 2015;82:423-7. doi: 10.1016/j.jbspin.2015.03.003. (SCI)
21. Ko TM&, Tsai CY&, Chen SY&, Yu KH&, Chen KS, et al. Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study. BMJ 2015;351:h4848. doi: 10.1136/bmj.h4848 (SCI)
22. Li TH, Huang CC, Yang YY, Lee KC, Hsieh SL, Hsieh YC, Alan LA, Lin HC, Lee SD. Tsai CY. Thalidomide improves the intestinal mucosal injury and suppresses mesenteric angiogenesis and vasodilatation by down-regulating inflammasomes-related cascades in cirrhotic rats. PLoS One 2016;11:e0147212. doi: 10.1371/journal.pone.0147212. (SCI)
23. Chen CH, Chen HA, Liao HT, Liu CH, Tsai CY, Chou CT. Suppressors of cytokine signaling in ankylosing spondylitis and their associations with disease severity, acute-phase reactants and serum cytokines. Clin Exp Rheumatol 2016 34:100-5. (SCI) 
24. Wu CC, Liu FL, Sytwu HK, Tsai CY, Chang DM. CD146+ mesenchymal stem cells display greater therapeutic potential than CD146– cells for treating collagen-induced arthritis in mice. Stem Cell Res Ther 2016;7:1-13. doi: 10.1186/s13287-016-0285-4 (SCI)
25. Lee HT, Wu TH, Lin CS, Lee CS, Tsai CY*, Chang DM*. The pathogenesis of systemic lupus erythematosus - from the viewpoint of oxidative stress and mitochondrial dysfunction. Mitochondrion 2016;30:1-7. (SCI)
26. Chen WS, Chang YS, Chang CC, Chang, DM, Chen,YH, Tsai, CY*, Chen JH*. Management and risk reduction of rheumatoid arthritis in individuals with obstructive sleep apnea: a nationwide population-based study in Taiwan. Sleep 2016;39:1883-1890. (SCI)
27. Chen MH, Chen CK, Chou HP, Chen MH, Tsai CY*, Chang DM. Rituximab therapy in primary Sjögren’s syndrome with interstitial lung disease. Clin Exp Rheumatol 2016;34:1077-84. (SCI)
28. Wu TH, Lee HT, Lai CC, Yang YH, Loong CC, Wang HK, Yu CL, Tsai CY*. Suppressor of cytokine signaling (SOCS) 1 is down-regulated in renal transplant recipients with rejection. Transplant Immunol 2016;38:54-9. doi: 10.1016/j.trim.2016.07.001. (SCI)
29. Hsieh SC, Tsai CY, Yu CL. Potential serum and urine biomarkers in patients with lupus nephritis and the unsolved problems. Open Acc Rheumatol 2016;8:81-91. doi: 10.2147/OARRR.S112829.
30. Wu CS, Hsieh TY, Yang KJ, Wu-Jan YJ, Chen YH, Chen CH, Tseng JC, Tsai WC, Tsai CY, Hsieh SC, Liu MF, Lan JL, Luo SF, Chen DY. Taiwan Rheumatology Association recommendations for the diagnosis and management of antineutrophil cytoplasmic antibody-associated vasculitis Formos J Rheumatol 2016;30:1-17.
31. Shen YC, Lai CC, Tsai CY*, Chen WS. The sustained therapeutic effectiveness of abatacept in patients with rheumatoid arthritis: an observational study in a medical center. Formos J Rheumatol 2016:30:43-9.
32. Tsao YP, Chen WS, Tsai CY. Ultrasonography and its applications in patients with Sjögren’s syndrome and sicca symptoms. Ann Rheum Dis 2016;75(suppl 2):873-4. doi: 10.1136/annrheumdis-2016-eular.4943 (in abstract) (SCI) 
33. Lee CJ, Huang YH, Lin HY, Chou CT, Tsai CY, Chen WS, Chen MH, Lin HC. Randomized controlled trial of entecavir prophylaxis in patients with inflammatory arthritis and inactive HBV infection undergoing biologics treatment: the first interim report. J Hepatol 2016;64(Suppl 2):S587. doi: 10.10.16/S0168-8278(16)01078-3 (in abstract) (SCI)
34. Li TH, Chang YS, Chang CC, Tsai CY. Identification of high probability of SLE development among ITP patients by means of decision-tree model: a nationwide cohort study. Formos J Rheumatol 2016;30:54-61.
35. Huang YF, Lai CC, Chou CT, Tsai CY, Chen WS. Rituximab retention rate in rheumatoid arthritis: a single center experience. Formos J Rheumatol 2016;30:62-7.
36. Li TH, Lee PC, Lee KC, Hsieh YC, Tsai CY, Yang YY, Huang SF, Tsai TH, Hsieh SL, Hou MC, Lin HC, Lee SD. Down-regulation of common NFκB-iNOS pathway by chronic thalidomide treatment improves hepatopulmonary syndrome and muscle wasting in rats with biliary cirrhosis. Sci Rep 2016; 6:39405. doi: 10.1038/srep39405. (SCI)
37. Lee HT, Wu TH, Lin CS, Lee CS, Pan SC, Chang DM, Wei YH, Tsai CY*. Oxidative DNA and mitochondrial DNA change in patients with SLE. Front Biosci (Landmark) 2017;22:493-503. doi: 10.2741/4497 (SCI)
38. Liu CJ, Tsai CY, Chiang SH, Tang SJ, Chen NJ, Mak TW, Sun GH, Sun KH. Triggering receptor expressed on myeloid cells-1 (TREM-1) deficiency augments BAFF production to promote lupus progression. J Autoimmun 2017;78:92-100. doi: 10.1016/j.jaut.2016.12.010. (SCI)
39. Liao HT, Chen WS, Chou CT, Tsai CY*. Paraneoplastic pemphigus in a man with spindle cell sarcoma of the left mediastinum. J Autoimmun Res 2017;4:1025 (1-3). 
40. Chen MH, Chen MH, Liu CY, Tsai CY, Huang DF, Lin HY, Lee MH, Huang YH. Hepatitis B virus reactivation in rheumatoid arthritis patients undergoing biologics treatment. J Infect Dis 2017;215:566-73. doi: 10.1093/infdis/jiw606. (SCI)
41. Li TH, Chang YS, Tsai CY*. Can we foresee SLE in ITP patients? To distinguish ITP patients with high risk of SLE by a nationwide cohort study-based decision tree. Ann Rheum Dis 2017;76(suppl 2):889. doi: 10.1136/annrheumdis-2017-eular.1359 (in abstract) (SCI)
42. Tsao YP, Tsai CY*. Responsiveness of systemic lupus erythematosus patients after rituximab treatment: a single center experience. Ann Rheum Dis 2017;76(suppl 2):1215. doi: 10.1136/annrheumdis-2017-eular.6648 (in abstract) (SCI)
43. Liu FL, Chen CL, Lee CC, Wu CC, Hsu TH, Tsai CY, HS Huang, Chang DM. The simultaneous inhibitory effect of niclosamide on RANKL-induced osteoclast formation and osteoblast differentiation. Int J Med Sci 2017;14:840-52. doi: 10.7150/ijms.19268 (SCI)
44. Tsao YP, Chen MH, Chen WS, Lai CC, Tsai CY*. Application of salivary gland ultrasonography in Sjögren syndrome and sicca symptoms: a single center experience. Arthritis Rheumatol 2017;69 (Suppl 10): A 268. (in abstract) WOS:000411824100268; ultrasonography-in-sjogren-syndrome-and-sicca-symptoms-a-single-center-experience/. (SCI)
45. Chen YC, Chen SC, Chou CT, Brown C, Lee JY, Lu WS, Tsai CY*. Effects of diacerein controlled release tablets in serum uric acid reduction in treating subjects with gout. Atrthritis Rheumatol 2017;69 (suppl 10):A1114. (in abstract) WOS:000411824102031; http://acrabstract/effects-of-diacerein-controlled-release-tablets-in-serum-uric-acid-reduction-in-treating-subjects-with-gout/. (SCI)
46. Chen MH, Tsao YP, Huang YH, Chou CT, Tsai CY*. High incidence of hepatitis related HBV reactivation in rheumatoid arthritis patients with resolved hepatitis B infection during rituximab treatment. Arthritis Rheumatol 2017;69 (suppl 10):A2385. (in abstract); WOS:000411824105227; (SCI)
47. Lai WF, Chin YP, Liu CW, Tsai CY*. Methotrexate-associated lymphoproliferative disease with multiple pulmonary nodules in a patient with rheumatoid arthritis. BMJ Case Rep 2017. doi: 10.1136/bcr-2017-221778. (published 1Dec 2017).
48. Tsai CK, Liao HT, Wu TH, Chen WS, Chen MH, Tsai CY*, Chang DM. SLE with pulmonary embolism and renal tubule acidosis. Med Case Report 2017;3:26. doi: 10.2176/2471-8041.100057
49. Tsai MH, Li H, Lai CC, Chen WS, Tsai CY. The long-term efficacy and safety of tocilizumab in younger and elderly patients with refractory rheumatoid arthritis: a single tertiary center cohort study. Formos J Rheumatol 2017;31:22-29
50. Tsai CY, Lu MC, Yu CL*. Can urinary exosomal micro-RNA detection become a diagnostic and prognostic gold standard for patients with lupus nephritis and diabetic nephropathy? J Lab Precis Med 2017;2(91):1-4. doi: 10.21037/jlpm.2017.06.05
51. Li TH, Liu CW, Lee PC, Huang CC, Lee KC, Hsieh YC, Yang YY, Hsieh SL, Lin HC, Tsai CY. Decoy receptor 3 analogous supplement protects steatotic rat liver from ischemia-reperfusion injury. J Chin Med Assoc 2017;80:391-400. doi: 10.1016/j.jcma.2016.11.008. (SCI) 
52. Huang SF, Chen MH, Wang FD, Tsai CY, Fung CP, Su WJ. Efficacy of isoniazid salvage therapy for latent tuberculosis infection in patients with immune-mediated inflammatory disorders: a retrospective cohort study in Taiwan. J Microbiol Immunol Infect 2018 (in press). doi: 10.1016/j.jmii.2017.04.001. (SCI)
53. Liao HT, Lin YF, Chou CT, Tsai CY*. Semaphorin 3A in ankylosing spondylitis. J Microbiol Immunol Infect 2018 (in press) doi: 10.1016/j.jmii.2018.07.001. (SCI)
54. Li TH, Liao HT, Huang YF, Shen YC, Chiu YC, Chen WS, Chen MH, Tsai CY*, Chang DM. The current status and unmet needs in the management of psoriatic arthritis: Viewpoint from physicians in Taiwan. J Formos Med Assoc 2018 (epub ahead of print). doi: 10.1016/j.jfma.2017.05.001. 
55. Liu CW, Tsai HC, Huang CC, Tsai CY, Su YB, Lin MW, Lee KC, Hsieh YC, Li TH, Huang SF, Yang YY, Hou MC, Lin HC, Lee FY, Lee SD. Effects and mechanisms of caffeine to improve immunologic and metabolic abnormalities in diet-induced obese rats. Am J Physiol Endocr Metab 2018 (e-pub ahead of print). doi: 10.1152/ajpendo.00094.2017 (SCI)
56. Liu CW, Huang CC, Tsai HC, Su YB, Huang SF, Lee KC, Hsieh YC, Li TH, Tsai CY, Chong LW, Ou SM, Yang YY, Fan WC, Hou MC, Lin HC, Lee SD. Serum adrenomedullin and urinary thromboxane B2 help early categorizing of acute kidney injury in de-compensated cirrhotic patients: A prospective cohort study. Hepatol Res 2018;48:E9-E21. doi: 10.1111/hepr.12917. (SCI)
57. Liao HT, Lin YF, Tsai CY, Chou CT. Bone morphogenetic proteins and Dickkopf-1 in ankylosing spondylitis. Scand J Rheumatol 2018;47:56-61. doi: 10.1080/03009742.2017.1287305. (SCI)
58. Yang TH, Wu TH, Chang YL, Liao HT, Hsu CC, Tsai CY*, Chou YC*. Cyclosporine for the treatment of lupus nephritis. Clin Nephrol 2018;89:277-85. doi: 10.5414/CN109325 (SCI)
59. Chang CL, Wu DY, Wu TH, Tsai CY. Establishing an experimental procedure for pre-transplantation matching for a patient with autoantibodies: a case report. J Biomed Lab Sci 2018;30:9-12.
60. Sun YS, Sun IT, Wang HK, Yang AH, Tsai CY, Huang CJ, Huang DF, Lai CC. Risk of complications of ultrasound-guided renal biopsy for adult and pediatric patients with systemic lupus erythematosus. Lupus 2018; doi: 10.1177/0961203317751048. (e-pub ahead of print). (SCI)
61. Chen MH, Lee MH, Liao HT, Chen WS, Lai CC, Tsai CY*. Health-related quality of life outcomes in patients with rheumatoid arthritis and ankylosing spondylitis after tapering biologic treatment. Clin Rheumatol 2018;37:429-38. doi: 10.1007/s10067-017-3965-2. (SCI)
62. Lee HT, Lin CS, Pan SC, Wu TH, Lee CS, Chang DM, Tsai CY*, Wei YH*. Alterations of oxygen consumption and extracellular acidification rates by glutamine in PBMCs of SLE patients. Mitochondrion 2018 (e-pub ahead of print). doi: 10.1016/j.mito.2018.01.002 (SCI)
63. Wu TH, Li KJ, Yu CL, Tsai CY*. Tamm–Horsfall protein is a potent immunomodulatory molecule and a disease biomarker in the urinary system. Molecules 2018;23(1), 200; (e-pub ahead of print) doi: 10.3390/molecules23010200 (SCI)
64. Liao HT, Li TH, Chen CH, Chen HA, Chen WS, La CC, Chou CT, Tsai CY*. Janus kinase-1 and 3 in ankylosing spondylitis. J Formos Med Assoc 2018 (e-pub ahead of print). doi: 10.1016/j.jfma.2018.02.001 (SCI)
65. Lim SS, Tsai CY, Liao HT. Telbivudine associated mitochondrial myopathy. Liver Int 2018 (epub ahead of print). doi: 10.1111/liv.13742 (SCI)
66. Liu CW, Hung ML, Liao HT, Tsai CY*. Large pseudoaneurysm of the superficial femoral artery in a patient with SLE with Salmonella group D infection. BMJ Case Rep 2018. doi: 10.1136/bcr-2017-222393 (published 20 Mar 2018).