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Deh-Ming Chang (張德明)

Deh-Ming Chang(張德明)

簡介

學歷
  1. 美國哈佛醫學院研究員 1988 - 1990
  2. 美國哈佛大學生物學碩士 1988 - 1990
  3. 國立台灣師範大學衛生教育學博士 2003 - 2007
  4. 國防醫學院醫學士 1974 - 1981
經歷 現職:
  1. - 迄今 國防醫學院醫學系內科學科教授 1995/8 -
  2. - 迄今 美國風濕學院院士
  3. - 迄今 台灣內科醫學會常務理事
  4. - 迄今 行政院衛生福利部醫事審議委員會委員
  5. - 迄今 國家衛生研究院董事
  6. - 迄今 中華民國風濕病醫學會學術委員會主席
  7. - 迄今 財團法人高等教育評鑑中心委員
  8. - 迄今 財團法人醫院評鑑暨醫療品質策進會董事
經歷:
  1. - 臺北榮民總醫院院長2015-2020
  2. - 臺北榮民總醫院副院長 2014/1 -2015/1
  3. - 國防部軍醫局局長 (陸軍一級中將) 2011/6 - 2014/1
  4. - 中華民國免疫學會理事長 2006 - 2009
  5. - 中華民國風濕病醫學會秘書長 1993 - 1999
  6. - 台灣內科醫學會監事召集人
  7. - 立法院醫務顧問
  8. - 國防醫學院生科所所長
  9. - 中研院生醫所計劃審查委員
  10. - 台灣醫學中心協會理事
  11. - 台灣醫院協會理事
  12. - 中華民國學校衛生學會理事
  13. - 中華民國紅十字會理事
  14. - 考試院考選部高等考試醫學類組副召集人暨命題委員
  15. - 健保局總額支付委員會委員
  16. - 馬偕紀念醫院醫療顧問
  17. - 彰化秀傳紀念醫院醫療顧問
  18. - 三軍總醫院風濕免疫科主任
  19. - 三軍總醫院民診處主任
  20. - 三軍總醫院內科部主任
  21. - 三軍總醫院行政副院長 2002 - 2003
  22. - 國防醫學院醫學系主任 2003 - 2004
  23. - 三軍總醫院教學副院長 2003 - 2004
  24. - 三軍總醫院醫療副院長兼執行官 2004 - 2005
  25. - 三軍總醫院院長 2005 - 2007
  26. - 國防醫學院院長 2007 - 2011
醫療專長
  1. 紅斑性狼瘡、痛風、過敏免疫、類風濕性關節炎
證照
  1. 中華民國免疫病專科醫師
  2. 中華民國風濕科專科醫師
  3. 中華民國內科專科醫師

著作

1. Chang DM, CT Chou, CF Lee, 1986, Bullous eruption of systemic lupus erythematosus. J Rheumatol ROC 3 : 54-59

2. Chang ML, CT Chou, CF Lee, DM Chang, 1986, Detection of circulating immune complexes by a Clq-microplate ELISA system. J Med Sci 6(3) : 231-6.

3. Chou CT, CF Lee, A Cheng, DM Chang, YS Ho, 1986, Pathologic studies in ankylosing spondylitis. J Rheumatol ROC 3: 19-29.

4. Chou CT, CF Lee, DM Chang, 1986, Infectious arthritis. J Med Sci 7: 29-36.

5. Chang DM, Fuh MMT, Jeng CY, Shian LR, 1986, The hypolipidemic effect of gemfibrozil on hyperlipidemia in patients with non-insulin-dependent diabetes mellitus. J Formosan Med Assoc 85 : 443-450. (SCI)

6. Lee CF, CT Chou, DM Chang, ML Chang, 1986, Lucigenin-dependent chemilunescence produced by the interaction between neutrophil and monosodium urate crystal. J Rheumatol (ROC) 5: 1-7.

7. Chang DM, CT Chou, CF Lee, ML Chang, 1987, HLA-DR Positive lymphocytes in peripheral blood and synovial fluid in patients with rheumatoid arthritis. J Formosan Med Assoc 86 : 43-51. (SCI)

8. Chang ML, CT Chou, CF Lee, DM Chang, 1987, Immune complexes in ankylosing spondylitis and rheumatoid arthritis. J Rheumatol ROC 4 : 111-21.

9. Chang ML, CT Chou, YC Chao, CF Lee, DM Chang, K Hsu, 1987, Circulating immune complexes in hepatitis B patients. J Med Sci. 7(5) : 263-9.

10. Chou CT, DM Chang, ML Chang, YS Ho, CF Lee, 1987, Subcutaneous nodule of  rheumatoid arthritis. J Med Sci 7(6) : 303-8.

11. Chou CT, SH Jau, L Pai, CF Lee, DM Chang, JH Liang, SM Huang, HR Sehumacher, 1987, The epidimiologic studies of rheumatic diseases in Hen-San Village in Taiwan.J Rheumatol (ROC) 4: 185-206.

12. Chou CT, CF Lee, DM Chang, ML Chang, DF Ching, 1987, Determination of interferon in sera and synovial fluids in different rheumatic disease. J Formosan Med Assoc 86(8): 829-32. (SCI)

13. Chang ML, CT Chou, YC Chao, CF Lee, DM Chang, K Hsu, 1987, Specific circulating immune complexes in patients with hepatitis B. Chinese J Microbiol Immunol 20: 119-26.

14. Chang ML, CT Chou, CF Lee, DM Chang, 1988, Rheumatoid factor and immune  complexes in sera of patients with rhumatoid arthritis. J Rheumatol (ROC) 5 : 17-21.

15. Chou CT, MJ Ting, ML Chang, DM Chang, SY Kao, 1988, Detection of yersinia antibody in different rheumatic disease-by ELISA. J Rheumatol (ROC) 5 : 1-5.

16. Chou CT, SY Kuo, ML Chang, DM Chang, CF Lee, MJ Ding, 1988, The role of enteric organisms in seronegative spondyloarthropathy. J Rheumatol (ROC) 5: 29-36.

17. Chang ML, CT Chou, CF Lee, DM Chang, 1988, The interrelationship of hepatitis Be antigen antibody and HBsAg-circulating immune complexes in asymptomatic    HBsAg carrier. J Microbiol Immunol 21(4) : 224-9.

18. Chang DM, CT Chou, CF Lee, ML Chang, 1988, Clinical features and prognositic actors in polymyositis/dermatomyositis. J Rheumatol ROC.

19. Chang ML, MY Chou, CT Chou, FY Chang, CF Lee, DM Chang, SF Lin, 1988, Circulating immune complexes in patients with pulmonary tuberculosis. J Formosan Med Assoc 87(9): 898-903.(SCI)

20. Chang DM, CT Chou, CF Lee, ML Chang, 1988, Enteropathic arthritis. Medical Digest. 6:227-29.

21. Lee CF, CT Chou, ML Chang, DM Chang. 1988. Reiter's disease. Medical Digest. 6: 219-23.

22. Chou CT, ML Chang, DM Chang, CF Lee. 1988. Ankylosing spondylitis. Medical Digest. 6:215-8.  

23. Chang ML, CT Chou, CF Lee, DM Chang. 1988. Psoriatic arthritis. Medical Digest. 6: 224-6.

24. Chu BL, DM Chang, CT Chou. 1988. Reactive arthritis. Medical Digest. 6: 234-9.

25. Chang DMCT Chou, CF Lee, ML Chang, 1988, Interleukin-1 production from monocyte induced by urate crystals. J Formosan Med Assoc 87(7): 707-11. (SCI)

26. Chou CT, SJ Lu, L Pai, DM Chang, CF Lee, SY Kao, ML Chang, 1988, Family study of ankylosing spondylitis. J Formosan Med Assoc 87(10): 989-99. (SCI)

27. Schur PH, DM Chang, P Baptiste, LC Uhteg, DC Hanson, 1990, Human monocytes produce IL-1 and inhibitor of IL-1 in response to two different signals. Clin Immunol Immunopathol 57, 45-63. (SCI)

28. Chang DM, 1990, Negative regulation of interleudin-1: An interleukin-1 inhibitor. Thesis for Master of Liberal Arts, Harvard University.

29. Chang DM, P Baptiste, PH Schur, 1990, The effect of anti-rheumatic drugs on interleukin 1 activity and IL-1 and IL-1 inhibitor production by human monocytes. J Rheumatol. 17: 1148-57. (SCI)

30. Chang ML, Chou CT, Lee CF, Chang DM, Kuo SY, Chou BL, Lin SF. 1990. The occurrence and clinical significance of antibodies to type 11 collagen in sera and synovial fluid of chinese patients with rheumatoid arthritis. J Formosan Med Assoc    89:326-30.

31. Chang DM, 1991, Immunogenetic and immunopathology in rheumatoid arthritis, Medical Digest 12:113-118.

32. Chang ML, CT Chou, CF Lee, DM-Chang, 1991, IgG rheumatoid factor (RF), IgM-RF, IgA-RF detected by ELISA in rheumatoid arthritis. J Rheumatol (ROC) 8: 1-10.

33. Chu SJ, DM Chang, SJ Wang, CT Chou, 1991, Hemophilic arthropathy- A case report. J Rheumatol (ROC) 8:22-28.

34. Chang DM, RB Eaton, PH Schur, 1992, Characterization of native and recombinant IL-1 inhibitor on T cell, monocyte, and B cell response to IL-1. Biomedical Research 13 (2): 113-24. (NSC 80-0412-B-016-100)(SCI)

35. Chang DM, 1992, Negative regulation of interleukin-1 in immune reactive cells. Immunol. Invest. 21(4) 333-342.(NSC 80-0412-B-016-64, NSC 80-0412-B-016-100)(SCI)

36. Chang DM, M Weinblatt, PH Schur, 1992, The effects of methotrexate on interleukin-1 in rheumatoid arthritis. J Rheumatol. 19: 1678-82. (SCI)

37. Chu SJ, DM Chang, 1992, Adult onset Still's disease. Medicine Today 19(2): 152-5.

38. ML Chang, DM Chang, SY Kuo, SJ Chu, 1993, The effect of tetrandrine and methotrexate on the production and activity of interleukin-1. J Rheumatol (ROC) 10: 1-10.

39. ML Chang, LL Yang, DM Chang, SY Kuo, SJ Chu, 1993, The influence of Chinese traditional medicine on the production and activity of interleukin-1. Chinese J Microbiol Immunol 26:15-24.

40. Chu SJ, DM Chang. 1993. Drug-induced immunological leukopenia. Medicine Today: 20(7): 554-560

41. Chu SJ, DM Chang, SY Kuo, ML Chang, YD Shu. 1993. Calcinosis in adult dermatomyositis-two case reports. J Med Sci 14(2): 133-40.

42. Chou CT, WL Wu, ML Chang, DM Chang. 1993. Efficacy and possible mechanisms of the Chinese herbs suching-huo-hsuei-tang in the treatment of adjuvant-induced arthritis in rats. Am J Chinese Medicine 21 (2): 159-70. (SCI)

43. Chang DM. 1993. The therapeutic principles and prognosis of systemic lupus erythematosus. Medical Digest 18(1): 31-8.

44. Chen CM, SJ Chu, DM Chang. 1993. CNS Lupus. Medical Digest 18(1): 11-6.

45. YF Lin, CP Ma, SD Shieh, JF Deng, L Pai, AR Lee, DM Chang,W-C Chiu, and RW Shu. 1993. Detection of medications adulterated in Chinese herb drugs by GC/MS. J Med Sci 14(1): 21-34.

46. Chang DM. 1993. Immunoregulatory effects of amiprilose hydrochloride. Arthritis Rheum 36 (5), S33. (SCI)

47. Khan MA, Lai JH, Chou CT, Chang DM, Liu HC. 1993. Recognizing and managing fractures in ankylosing spondylitis. J Musculoskeletal M. 10(1): 45-57.

48. Chang DM. 1993. The role of cytokines in heat stroke. Immunol. Invest. 22 (8), 553-561. (NSC-81-0412-B-016-516)(SCI)

49. Chou CT, L Pei, DM Chang, CF Lee, HR Schumacher Jr, MH Liang. 1994. Prevalence of rheumatic diseases in Taiwan: A population study of urban, suburban, rural differences. J Rheumatol 21: 302-6. (SCI)

50. Chu SJ, DM Chang, SY Kuo, ML Chang, HS Lee, A Chen, SD Shieh. 1994. Lupus nephritis: An analysis of 70 cases. Chin Med J (Taipei) 53: 27-36.

51. Chang DM. 1994. Mechanisms of methotrexate action in rheumatoid arthritis. 1994. Rheumatology Review. (3): 43-8. (NSC-82-0409-B-016-093)

52. Chu SJ, DM Chang, SY Kuo, CM Hsu, CM Chen, ML Chang. 1994. Intermittent  intravenous treatment of lupus nephritis with cyclophosphamide: Four-year experience with twenty-four patients. Chin Med J (Taipei) 53: 325-30.

53. Kuo J, Ching Hu, JK Chang, YS Yuh, DM Chang. 1994. Neonatal lupus with non-infective heaptitis, CNS involvement and hyaline membrane disease. J Rheumatol (R.O.C.) 11: 17-26.

54. Chen CM, Chu SJ, SY Kuo, ML Chang, CM Hsu, CC Chang, TY Shih, and DM Chang. 1994. Hospital mortality in systemic lupus erythematosus: 44 cases analysis. J Med Sci 14(6): 405-10.

55. YF Lin, SH Chyr, DM Chang, KC Lu, LK Diang, SH Lin, KS Kao, SD Shieh.  Interleukin-1 production during hemodialysis: The effects of dialytic membrane. J Nephrol R.O.C. 8(3) 141-8. 1994.

56. Shih TY, Chang CC, Chen CM, Hsu CM, Kuo SY, Chu SJ, Chang ML, Chang DM. 1994. Clinical observation of Juvenile ankylosing spondylitis-Analysis of 72 cases. J Rheumatol (R.O.C.) 11: 71-83.

57. Chang DM, MF Shaio. 1994. Production of Interleukin-1 and interleukin-1 inhibitor by human monocytes exposed to dengue virus. J Infect Dis, 170: 811-7. (NSC 80-0412-B-016-64, NSC 81-0412-B-016-502)(SCI)

58. Hsu CM, SY Kuo, SJ Chu, LF, Sheu, DM Chang. 1994. Positive antinuclear antibody in peripheral T cell lymphoma: a case report. Chin Med J (Taipei) 54: 359-62.

59. Kuo SY, SJ Chu, CM Hsu, CM Chen, ML Chang, DM Chang. 1994. An experimental model of osteoarthritis in rabbit. Chin Med J (Taipei) 54: 377-81.

60. Chang CC, Liao ST, Kuo SY, Chu SJ, Chen CM, Shih TY, Chang ML, Chang DM. 1995. Acquired immunodeficiency syndrome with CNS toxoplasmosis: A case report. Chin Med J (Taipei) 55: 69-73.

61. Hsu CM, Kuo SY, Chu SJ, Shih TY, Chen A, Huang GS, DM Chang. 1995. Coexisting IgA nephropathy and leukocytoclastic cutaneous vasculitis associated with ankylosing spondylitis: A case report. Chin Med J (Taipei) 55: 83-88.

62. Tzeng GS, Chen CM, Chang DM. 1995. Hypolipidemic medicines related rheumatism. Medical Digest. 20(5), 403-6.

63. Chang DM. 1995. Cellular signals for the induction of human interleukin-1 receptor antagonist. Clin Immunol Immunopathol. 74 (1): 23-30. (NSC 81-0412-B-016-516, NSC 82-0409-B-016-093)(SCI)

64. Chang CC, Shih TY, Chu SJ, Kuo SY, Chen CM, Hsu CM, Chang ML, Chang DM. 1995. Lupus in Chinese male: A retrospective study of 61 patients. Chin Med J     (Taipei) 55: 143-50.

65. Chen CM, Chang DM, SY Kuo, SJ Chu, ML Chang. 1995. Polymyositis and  Dermatomyositis: Analysis of 42 cases. J Med Sci 15 (4): 281-92.

66. Tzeng GS, Chang DM, SY Kuo, Chu SJ, CM Chen, CM Hsu, ML Chang. 1995. Adult Still's Disease: Analysis of 11 cases. J Med Sci 16 (1): 61-7.

67. Chang CC, Liao ST, Kuo SY, Chu SJ, Chen CM, Shih TY, Chang ML, Chang DM. 1995. Acquired Immunodeficiency Syndrome with CNS Toxoplasmosis: A case report. Chin Med J (Taipei) 55: 69-73.

68. Chang DM, Chiao SF. 1995. The clinical and immunological effects of cyclosporin A on patients with rheumatoid arthritis. Clin Rheumatol 14, 537-43.(SCI)  

69. Chang DM. 1995. Immunoregulatory effects of a synthetic monosaccharide. Immunopharmacol Immuno T. 17 (3), 437-50. (SCI)

70. Chen CM, Chang DM, Chyi LP. et al. 1995. X-linked agammaglobulinemia: A case report. Chin Med J (Taipei) 56: 427-31.

71. Tzeng GS, Chang DM, Kuo SY, Chang ML. Mortality in rheumatoid arthritis. J  Rheumatol (ROC) 12: 29-38, 1995.

72. Chen WT, Chang DM. 1996. Heterogenous clinical characteristics of identical twins concordant for systemic lupus erythematosus: A report of one pair of twins. Chin Med J (Taipei) 57: 224-7.

73. Chang DM. The overview of vasculitis. Medical Digest 1996: 22(5), 372-6.

74. Lin WS, Tzeng GS, Chang DM. Polyarteritis nodosa. Medical Digest 1996: 22(5), 384-8.

75. Chang DM. Cutaneous vasculitis. Medical Digest 1996: 22(5), 376-80.

76. Tzeng GS, Chen CM, Kuo SY, Chang DM. Wegener's granuloma. Medical Digest 1996: 22(5), 389-92.

77. Wang HJ, Wan HL, Yang TS, Wang DS, Chen TM, Chang DM. Acceleration of skin graft healing by growth factors. Burns 22(1): 10-4, 1996. (SCI).

78. Lin YF, Chang DM, Shaio MF, Lu KC, Chyr SH, Li BL, Sheih SD. Cytokine  production during hemodialysis: Effects of dialytic membrane and complement activation. Am J Nephrol 16, 293-9, 1996. (SCI)

79. Chang DM. Advanced therapy in rheumatoid arthritis. Chin Med J (Taipei) 57 (6): 33-4, 1996.

80. Chang DM. Y.A. Ding, S.Y. Kuo, M.L. Chang, J. Wei. Cytokines and cell surface markers in prediction of cardiac allograft rejection. Immunol. Invest. 25(1&2), 13-21, 1996(SCI).

81. Chang DM, WY Chou. The production and characterization of a modified recombinant interleukin-1 receptor antagonist. Immunol Invest 25 (4), 355-68, 1996 (SCI). (NSC 84-2331-B-016-032)

82. Cheng SM, Chang DM, Lee WH, Ding YA. Acute myocarditis as an initial manifestation of systemic lupus erythematosus: A case report. Chin Med J (Taipei) 58: 205-8, 1996.

83. Chang DM. Tools in prediction of cardiac allograft rejection. Bio/Pharma Quarterly 2(2), 4-5, 1996.

84. Chang DM. Cytokines in rheumatoid arthritis. J Internal Med S130-7, 1996.

85. Lin MR, Chang DM, Lai WY, Ding YA. Echocardiographic detection of cardiac abnormalities in asymptomatic systemic lupus erythematosus patients. Acta Cardiol Sin 12, 112-8, 1996.

86. Wu YL, Chang CC, Chang HC, Liao ST, Shih LS, Tseng KS, Lai JH, Kuo SY, Chang ML, Chang DM. Mesneteric thrombosis associated with anticardiolipin      antibodies in a patient with systemic lupus erythematosus. J Rheumatol, R.O.C. 13 (3 &4) 27-39, 1996.

87. Chang DM. Advanced therapy in rheumatoid arthritis. Medicine Today 24(1): 23-6, 1997.

88. Chang DM, Chang WY, Kuo SY, Chang ML. The effects of traditional anti-  rheumatic herbal medicines on immune response cells. J Rheumatol 24: 436-41, 1997. (SCI)(March)

89. Chou CT, Lee CC, Chang DM, Buxbaum JN, Jacobson DR. Familial amyloidosis in one Chinese family: clinical, immunological, and molecular genetic analysis. J Intern Med 241(4):327-31, 1997 (SCI)(April)

90. Chiang CH, Hsu K, Yan HC, Harn HJ, Chang DM. PGE1, dexamethasone, U-     74389G, or Bt2-cAMP as an additive to promote protection by UW solution in I/R injury. J Appl Physiol 83(2): 583-90, 1997. (SCI) (August)

91. Chang DM. Interleukin-1 and interleukin-1 receptor antagonist in systemic lupus erythematosus. Immunological Investigations, 26(5-7), 649-59, 1997. (SCI)(Aug-Dec.)

92. Chang DM, Kang Hsu, Yu-An Ding, Chi-Huei Chiang. Interleukin-1 in ischemia-reperfusion acute lung injury. Am. J. Resp. & Critical Care Medicine, 156 (4), 1230-4, 1997. (SCI)(October)