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藍耿立 (Keng-Li Lan)


  • 學歷
    • 密西根大學 醫學院 藥理博士
    • 國立陽明大學 醫學院 醫學系 醫學士
  • 經歷
    • 2023- 迄今 臺北榮民總醫院 重粒子及放射腫瘤部 重粒子治療科 科主任
    • 2023- 迄今 臺北榮民總醫院 重粒子及放射腫瘤部 主治醫師
    • 2022- 迄今 國立陽明交通大學 醫學院 傳醫所 教授
    • 2019- 2023 臺北榮民總醫院 腫瘤醫學部 放射腫瘤科 科主任
    • - 臺北榮民總醫院 腫瘤醫學部 放射腫瘤科 主治醫師
    • - 大阪重粒子治療中心 進修
    • - 日本國立放射線醫學總合研究所(National Institute of Radiological Sciences, NIRS) 輻射生物研究
    • - 國立陽明大學 醫工學院 生物醫學影像暨放射科學系暨研究所 兼任助理教授
    • - 美國德州大學 安德森癌症中心 兼任講師
    • - 美國德州大學 安德森癌症中心 博士後研究員
  • 醫療專長
    1. 食道癌、肺癌、腸胃道腫瘤(肝癌、膽管癌、胰臟癌、胃癌)、大腸直腸癌、生殖泌尿道腫瘤等放射治療、粒子放射治療、分子生物及免疫治療研究、癌症新藥開發
  • 證照
  • 語言專長



  1. F Ou-Yang, KL Lan, CT Chen, JC Liu, CL Weng, CK Chou, X Xie, JY Hung, Y Wei, GN Hortobagyi, MC Hung.  Endostatin-cytosine deaminase fusion protein suppresses tumor growth by targeting neovascular endothelial cells.  Cancer Res 66(1) (2006) 378-84. (IF: 11.2; Oncology 28/318)

  2. FT Hsu, YC Liu, CL Tsai, PF , CH Chang, KL Lan.  Preclinical Evaluation of Recombinant Human IL15 Protein Fused with Albumin Binding Domain on Anti-PD-L1 Immunotherapy Efficiency and Anti-Tumor Immunity in Colon Cancer and Melanoma.  Cancers (Basel) 2021 Apr; 13(8): 1789. (IF: 6.639; Oncology 51/242)

  3. PF Yueh, YH Lee, IT Chiang, WT Chen, KL Lan*, CH Chen*, FT Hsu*.  Suppression of EGFR/PKC-δ/NF-κB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer.  Front Oncol 2021 Oct; 11: 735183. (IF: 6.244; Oncology 62/242)

  4. FT Hsu, CL Tsai, IT Chiang, KH Lan, PF Yueh, WY Liang, CS Lin, Y Chao, KL Lan*.  Synergistic Effect of Abraxane That Combines Human IL15 Fused with An Albumin-Binding Domain on Murine Models of Pancreatic Ductal Adenocarcinoma.  J Cell Mol Med 2022 Apr; 26(7): 1955-68. Epub 2022 Feb. (IF: 5.31; Medicine, Research & Experimental 44/140; Cell Biology 73/195)

  5. KL Lan, H Zhong, M Nanamori, RR Neubig.  Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Galphai and Galphao deactivation. Galpha specificity of RGS4 AND RGS7.  J Biol Chem 275(43) (2000) 33497-503. (IF: 5.157; Biochemistry & Biology 81/311)

  6. KL Lan, NA Sarvazyan, R Taussig, RG Mackenzie, PR DiBello, HG Dohlman, RR Neubig.  A point mutation in Galphao and Galphai1 blocks interaction with regulator of G protein signaling proteins.  J Biol Chem 273(21) (1998) 12794-7. (IF: 5.157; Biochemistry & Biology 81/311)

  7. Shen YA, Lan KL, Chang CH, Lin LT, He CL, Chen PH, Lee TW, Lee YJ, Chuang CM.  Intraperitoneal 188Re-Liposome Delivery Switches Ovarian Cancer Metabolism From Glycolysis to Oxidative Phosphorylation and Effectively Controls Ovarian Tumour Growth in Mice.  Radiother Oncol 2016 May; 119(2): 282-90. (IF: 4.817; Radiology, Nuclear Medicine & Medical Imaging 10/124; Oncology 39/213)

  8. YS Huang, WC Hsu, CH Lin, SN Lo, CN Cheng, MS Lin, TW Lee, CH Chang*, KL Lan*.  Bi-Functional Radiotheranostics of 188 Re-Liposome-Fcy-hEGF for Radio- and Chemo-Therapy of EGFR-Overexpressing Cancer Cells.  Int J Mol Sci 2021 Feb; 22(4): 1902. (IF: 4.556; Biochemistry & Molecular Biology 74/297; Chemistry, Multidisciplinary 48/177)

  9. Li JJ, Lan KL, Chang SF, Chen YF, Tsai WC, Chiang PH, Lin MH, Fischer WB, Shih YS, Yen SH, Liu RS, Tsay YG, Wang HE*, Chang CA*.  Development and Characterization of the Recombinant Human VEGF-EGF Dual-Targeting Fusion Protein as a Drug Delivery System.  Bioconjug Chem 2015 Dec; 26(12): 2481-96. (IF: 4.5; Biochemical Research Methods 10/77; Chemistry, Organic 10/59; Chemistry, Multidisciplinary 31/163; Biochemistry & Molecular Biology 64/289)

  10. YR Pan, CE Wu, MH Chen, WK Huang, HJ Shih, KL Lan*, CN Yeh*.  Comprehensive Evaluation of Immune-Checkpoint DNA Cancer Vaccines in a Rat Cholangiocarcinoma Model.  Vaccines (Basel) 2020 Nov; 8(4): 703. (IF: 4.086; Medicine, Research & Experimental 50/139; Immunology 59/159)

  11. KL Lan, F Ou-Yang, SH Yen, HL Shih, KH Lan.  Cationic liposome coupled endostatin gene for treatment of peritoneal colon cancer.  Clin Exp Metastasis 27(5) (2010) 307-18. (IF: 4; Oncology 136/318)

  12. KL Lan, SH Yen, RS Liu, HL Shih, FW Tseng, KH Lan.  Mutant Bik gene transferred by cationic liposome inhibits peritoneal disseminated murine colon cancer.  Clin Exp Metastasis 24(6) (2007) 461-70. (IF: 4; Oncology 136/318)

  13. PF Yueh, YH Lee, CY Fu*, CB Tung*, FT Hsu*, KL Lan*.  Magnolol Induces the Extrinsic/Intrinsic Apoptosis Pathways and Inhibits STAT3 Signaling-Mediated Invasion of Glioblastoma Cells.  Life (Basel) 2021 Dec; 11(12): 1399. (IF: 3.817; Biology 27/93)

  14. KH Lan, CL Tsai, YY Chen, TL Lee, CW Pai, Y Chao, KL Lan*.  Affibody-Conjugated 5-Fluorouracil Prodrug System Preferentially Targets and Inhibits HER2-Expressing Cancer Cells.  Biochem Biophys Res Commun 2021 Dec; 582: 137-43. Epub 2021 Oct. (IF: 3.575; Biophysics 30/71; Biochemistry & Molecular Biology 173/295)

  15. Chang CM, Lan KL, Huang WS, Lee YJ, Lee TW, Chang CH, Chuang CM*.  188Re-Liposome Can Induce Mitochondrial Autophagy and Reverse Drug Resistance for Ovarian Cancer: From Bench Evidence to Preliminary Clinical Proof-of-Concept.  Int J Mol Sci 2017 Apr; 18(5): 903. (IF: 3.226; Chemistry, Multidisciplinary 54/166; Biochemistry & Molecular Biology 116/286)

  16. Lee WP, Lan KL, Liao SX, Huang YH, Hou MC, Lan KH*.  Inhibitory Effects of Amentoflavone and Orobol on Daclatasvir-Induced Resistance-Associated Variants of Hepatitis C Virus.  Am J Chin Med 2018 -; 46(4): 835-52. Epub 2018 May. (IF: 3.12; Integrative & Complementary Medicine 3/27; Medicine, General & Internal 31/155)

  17. KH Lan, YC Liu, YS Shih, CL Tsaid, SH Yen, KL Lan  A DNA vaccine against cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) prevents tumor growth.  Biochem Biophys Res Commun 440(2) (2013) 222-8. (IF: 3.1; Biophysics 29/74; Biochemistry & Molecular Biology 137/315)

  18. KH Lan, YS Shih, CA Chang, SH Yen, KL Lan  5-Fluorocytosine combined with Fcy-hEGF fusion protein targets EGFR-expressing cancer cells.  Biochem Biophys Res Commun 428(2) (2012) 292-7. (IF: 3.1; Biophysics 29/74; Biochemistry & Molecular Biology 137/315)

  19. Wang SJ, Huang WS, Chuang CM, Chang CH, Lee TW, Ting G, Chen MH, Chang PM, Chao TC, Teng HW, Chao Y, Chen YM, Lin TP, Chang YJ, Chen SJ, Huang YR, Lan KL*.  A Phase 0 Study of the Pharmacokinetics, Biodistribution, and Dosimetry of 188Re-Liposome in Patients with Metastatic Tumors.  EJNMMI Res 2019 May; 9(1): 46. (IF: 3; Radiology, Nuclear Medicine & Medical Imaging 40/129)

  20. KL Lan, AE Remmers, RR Neubig.  Roles of G(o)alpha tryptophans in GTP hydrolysis, GDP release, and fluorescence signals.  Biochemistry 37(3) (1998) 837-43. (IF: 2.9;Biochemistry & Molecular Biology 203/315)

  21. KL Lan, KH Lan, ML Sheu, MY Chen, YS Shih, FC Hsu, HM Wang, RS Liu, SH Yen.  Honokiol inhibits hypoxia-inducible factor-1 pathway.  Int J Radiat Biol 87(6) (2011) 579-90. (IF: 2.6;Nuclear Science & Technology 13/42; Biology 35/112)

  22. Kang YM, Lan A, Huang YH, Hsu KM, Chao Y, Lan KL*.  Identification of Key Genes and Pathways Associated With Topotecan Treatment Using Multiple Bioinformatics Tools.  J Chin Med Assoc 2020 May; 83(5): 446-53. Epub 2020 Apr. (IF: 2.17; Medicine, General & Internal 63/165)

  23. Lee WP, Lan KL, Liao SX, Huang YH, Hou MC, Lan KH*.  Antiviral Effect of Saikosaponin B2 in Combination with Daclatasvir on NS5A Resistance-Associated Substitutions of Hepatitis C Virus.  J Chin Med Assoc 2019 May; 82(5): 368-74. Epub 2019 Mar. (IF: 1.894; Medicine, General & Internal 67/160)