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部主任

牛道明 Niu, Dau-Ming

牛道明

掛號

現任

臺北榮民總醫院 兒童醫學部主任

臺北榮民總醫院 罕見疾病治療中心主任

國立陽明大學 臨床醫學所教授

 

學歷

1. 國立陽明大學臨床醫學所博士, 2001-2004

2. 美國杜克大學醫學遺傳學研究員, 1995-1996

3. 臺灣大學醫學院附設醫院臨床研究員, 1993-1994

4. 高雄醫學院醫學系學士, 1980-1987

 

經歷:

1. 台北榮民總醫院兒童醫學部主任, 2018-

2. 台北榮民總醫院兒童遺傳內分泌科主任, 2014-2018

3. 台北榮民總醫院罕見疾病治療中心主任, 2011-

4. 國立陽明大學臨床醫學所教授, 2011-

5. 國立陽明大學臨床醫學所副教授, 2008-2011

6. 台北榮民總醫院兒童醫學部遺傳諮詢中心主任, 2009-2020

7. 國立陽明大學臨床醫學所助理教授, 2004-2008

8. 台北榮民總醫院兒童醫學部主治醫師, 1994-

 

獲獎紀錄

1. 110年榮獲立法院厚生會-醫療奉獻獎

2. 110年以「獨步全球-法布瑞氏症研究治療中心」榮獲廿三屆SNQ國家生技醫療品質獎金獎

3. 110年第25屆學術類傑出校友-高雄醫學大學

4. 109年第十八屆學術類傑出校友-國立陽明大學

5. 108年衛生福利部罕見疾病防治貢獻獎

6. 108年台北市醫師公會杏林獎

7. 107年度科技部傑出研究獎

8. 107年臺北榮民總醫院優良醫師

9. 107年臺北榮民總醫院『學術論文獎』第一名

10. 105年度國立陽明大學學生網路教學評估優良教師

11. 99年度行政院國軍退除役官兵輔導委員會優良醫師

12. 99年國民健康局「99年度照護罕見疾病個案之績優醫事人員獎」第一名

13. 99年陽明大學臨床醫學所優良教師

14. 98年行政院衛生署98年度照護罕見疾病個案之績優醫事人員獎第一名

15. 96年度行政院國軍退除役官兵輔導委員會優良醫師

16. 95年度第二屆教育百人團總統獎

17. 95年度行政院國軍退除役官兵輔導委員會優良醫師

18. 94年度行政院衛生署罕見疾病個案績優獎績優醫事人員嘉獎

19. 91年度行政院衛生署罕見疾病個案績優醫事人員第二名
 

代表著作 (* 通訊作者)

  1. Hsu TR, Hung SC, Chang FP, Yu WC, Sung SH, Hsu CL, Dzhagalov I, Yang CF, Chu TH, Lee HJ, Chang SK, Liao HC, Lin HY, Liao TC, Lee PC, Li HY, Yang AH, Ho HC, Chiang CC, Lin CY, Desnick RJ, Niu DM*. Later Onset Fabry Disease, Cardiac Damage Progress in Silence: Experience With a Highly Prevalent Mutation. J Am Coll Cardiol. 2017. 68:2554-2563.
  2. Hsu MJ, Chang FP, Lu YH, Hung SC, Wang YC , Yang AH, Lee HJ, Sung SH, Wang YF, Yu WC, Hsu TR, Huang PH, Chang SK, Ivan Dzhagalov , Hsu CL, Niu DM*. Identification of lysosomal and extralysosomal globotriaosylceramide (Gb3) accumulations before the occurrence of typical pathological changes in the endomyocardial biopsies of Fabry disease patients. Genetics in Medicine. 2018; 21(1):224-232.
  3. Lin HY, Chong KW, Hsu JH, Yu HC, Shih CC, Huang CH, Lin SJ, Chen CH, Chiang CC, Ho HJ, Lee PC, Kao CH, Cheng KH, Hsueh C, Niu DM*. High incidence of the cardiac variant of Fabry disease revealed by newborn screening in the Taiwan Chinese population. Circ Cardiovasc Genet. 2009. 2(5):450-6.
  4. Yang CF, Yang CC, Liao HC, Huang LY, Chiang CC, Ho HC, Lai CJ, Chu TH, Yang TF, Hsu TR, Soong WJ, Niu DM*. Very Early Treatment for Infantile-Onset Pompe Disease Contributes to Better Outcomes. J Pediatr. 2016. 169:174-80.
  5. Liu KM, Liu TT, Lee NC, Cheng LY, Hsiao KJ, Niu DM*. Long-term follow-up of Taiwanese Chinese patients treated early for 6-pyruvoyl-tetrahydropterin synthase deficiency. Arch Neurol. 2008. 65(3):387-92.
  6. Niu DM, Hsu JH, Chong KW, Huang CH, Lu YH, Kao CH, Yu HC, Lo MY, Jap TS. Six new mutations of the thyroglobulin gene discovered in Taiwanese children presenting with thyroid dyshormonogenesis. J Clin Endocrinol Metab. 2009. 94(12):5045-52.
  7. Niu DM, Hwang B, Chu YK, Liao CJ, Wang PL, Lin CY. High prevalence of a novel mutation (2268 insT) of the thyroid peroxidase gene in Taiwanese patients with total iodide organification defect, and evidence for a founder effect. J Clin Endocrinol Metab. 2002. 87(9):4208-12.
  8. Niu DM, Lin CY, Hwang B, Jap TS, Liao CJ, Wu JY. Contribution of genetic factors to neonatal transient hypothyroidism. Arch Dis Child Fetal Neonatal Ed. 2005. 90(1):F69-72.
  9. Niu DM, Hwang B, Hwang HW, Wang NH, Wu JY, Lee PC, Chien JC, Shieh RC, Chen YT. A common SCN5A polymorphism attenuates a severe cardiac phenotype caused by a nonsense SCN5A mutation in a Chinese family with an inherited cardiac conduction defect. J Med Genet. 2006. 43(10):817-21.
  10. Niu DM, Pan CC, Lin CY, Hwang B, Chung MY. Mosaic or chimera? Revisiting an old hypothesis about the cause of the 46,XX/46,XY hermaphrodite. J Pediatr. 2002. 140(6):732-5.
  11. Lu YH, Cheng LM, Huang YH, Lo MY, Wu TJ, Lin HY, Hsu TR, Niu DM*. Heterozygous carriers of classical homocystinuria tend to have higher fasting serum homocysteine concentrations than non-carriers in the presence of folate deficiency. Clin Nutr. 2015. 34(6):1155-8.
  12. Lu YH, Huang YH, Cheng LM, Yu HC, Hsu JH, Wu TJ, Lo MY, Lin A, Lin CY, Wu JY, Niu DM*. Homocystinuria in Taiwan: an inordinately high prevalence in an Austronesian aboriginal tribe, Tao. Mol Genet Metab. 2012. 105(4):590-5.

 

五年內著作 (* 通訊作者)

  1. Yang CF, Niu DM, Tai SK, Wang TH, Su HT, Huang LY, Soong WJ. Airway Abnormalities in Very Early Treated Infantile-Onset Pompe Disease: A Large-Scale Survey by Flexible Bronchoscopy. 2020; Am J Med Genet A. [published online ahead of print]
  2. Ramaswami U, Beck M, Hughes D, Kampmann C, Botha J, Pintos-Morell G, West ML, Niu DM, Nicholls K, Giugliani R; FOS Study Group. Cardio- Renal Outcomes With Long- Term Agalsidase Alfa Enzyme Replacement Therapy: A 10- Year Fabry Outcome Survey (FOS) Analysis. Drug Des Devel Ther. 2019;13:3705-3715.
  3. Lin HY, Lee CL, Chiu PC, Niu DM, Tsai FJ, Hwu WL, Lin SJ, Lin JL, Chang TM, Chuang CK, Lin SP. Relationships Among Height, Weight, Body Mass Index, and Age in Taiwanese Children With Different Types of Mucopolysaccharidoses. Drug Des Devel Ther. 2019;13:3705–3715.
  4. Tseng SY, Niu DM, Chu TH, Yeh YC, Huang MH, Yang TF, Liao HC, Chiang CC, Ho HC, Soong WJ, Yang CF. Very rare condition of multiple Gaucheroma: A case report and review of the literature. Mol Genet Metab Rep. 2019;20:100489.
  5. Lee CL, Lin HY, Chuang CK, Chiu HC, Tu RY, Huang YH, Hwu WL, Tsai FJ, Chiu PC, Niu DM, Chen YJ, Chao MC, Chang TM, Lin JL, Chang CY, Kao YC, Lin SP. Functional independence of Taiwanese patients with mucopolysaccharidoses. Mol Genet Genomic Med. 2019;7(8):e790.
  6. Lin HY, Chen MR, Lin SM, Hung CL, Niu DM, Chang TM, Chuang CK, Lin SP. Cardiac characteristics and natural progression in Taiwanese patients with mucopolysaccharidosis III. Orphanet J Rare Dis. 2019;14(1):140.
  7. Chu TH, Chien YH, Lin HY, Liao HC, Ho HJ, Lai CJ, Chiang CC, Lin NC, Yang CF, Hwu WL, Lee NC, Lin SP, Liu CS, Hu RH, Ho MC, Niu DM*. Methylmalonic acidemia/propionic acidemia - the biochemical presentation and comparing the outcome between liver transplantation versus non-liver transplantation groups. Orphanet J Rare Dis. 2019;14(1):73.
  8. Lin HY, Chan WC, Chen LJ, Lee YC, Yeh SI, Niu DM, Chiu PC, Tsai WH, Hwu WL, Chuang CK, Lin SP. Ophthalmologic manifestations in Taiwanese patients with mucopolysaccharidoses. Mol Genet Genomic Med. 2019;7(5):e00617.
  9. Lin HY, Lee CL, Lo YT, Wang TJ, Huang SF, Chen TL, Wang YS, Niu DM, Chuang CK, Lin SP. The relationships between urinary glycosaminoglycan levels and phenotypes of mucopolysaccharidoses. Mol Genet Genomic Med. 2018;6(6):982-992.
  10. Lin HY, Chuang CK, Ke YY, Hsu CC, Chiu PC, Niu DM, Tsai FJ, Hwu WL, Lin JL, Lin SP. Long-term effects of enzyme replacement therapy for Taiwanese patients with mucopolysaccharidosis IVA. 2018. pii: S1875-9572(18)30270-5.
  11. Lin HY, Chen MR, Lin SM, Hung CL, Niu DM, Chuang CK, Lin SP. Cardiac features and effects of enzyme replacement therapy in Taiwanese patients with Mucopolysaccharidosis IVA. Orphanet J Rare Dis. 2018;13(1):148.
  12. Lin HY, Chuang CK, Lee CL, Tu RY, Lo YT, Chiu PC, Niu DM, Fang YY, Chen TL, Tsai FJ, Hwu WL, Lin SJ, Chang TM, Lin SP. Mucopolysaccharidosis III in Taiwan: Natural history, clinical and molecular characteristics of 28 patients diagnosed during a 21-year period. Am J Med Genet A. 2018;176:1799-1809.
  13. Shibata N, Hasegawa Y, Yamada K, Kobayashi H, Purevsuren J, Yang Y, Dung VC, Khanh NN, Verma IC, Bijarnia-Mahay S, Lee DH, Niu DM, Hoffmann GF, Shigematsu Y, Fukao T, Fukuda S, Taketani T, Yamaguchi S. Diversity in the incidence and spectrum of organic acidemias, fatty acid oxidation disorders, and amino acid disorders in Asian countries: Selective screening vs. expanded newborn screening. Mol Genet Metab Rep. 2018;16:5-10.
  14. Hsu MJ, Chang FP, Lu YH, Hung SC, Wang YC , Yang AH, Lee HJ, Sung SH, Wang YF, Yu WC, Hsu TR, Huang PH, Chang SK, Ivan Dzhagalov , Hsu CL, Niu DM*. Identification of lysosomal and extralysosomal globotriaosylceramide (Gb3) accumulations before the occurrence of typical pathological changes in the endomyocardial biopsies of Fabry disease patients. Genetics in Medicine. 2018; 21(1):224-232..
  15. Lin HY, Chuang CK, Chen MR, Lin SJ, Chiu PC, Niu DM, Tsai FJ, Hwu WL, Chien YH, Lin JL, Lin SP. Clinical characteristics and surgical history of Taiwanese patients with mucopolysaccharidosis type II: data from the hunter outcome survey (HOS). Orphanet J Rare Dis. 2018 Jun 4;13(1):89
  16. Lee CL, Lin HY, Tsai LP, Chiu HC, Tu RY, Huang YH, Chien YH, Lee NC, Niu DM, Chao MC, Tsai FJ, Chou YY, Chuang CK, Lin SP. Functional independence of Taiwanese children with Prader-Willi syndrome. Am J Med Genet A. 2018;176(6):1309-1314.
  17. Yung-Hsiu Lu, Po-Hsun Huang, Li-Yun Wang, Ting-Rong Hsu, Hsing-Yuan Li, Pi-Chang Lee, Yu-Ping Hsieh, Sheng-Che Hung, Yu-Chen Wang, Sheng-Kai Chang, Ya-Ting Lee, Ping-Hsun Ho, Hui-Chen Ho, Dau-Ming Niu*. Improvement in the sensitivity of newborn screening for Fabry disease among females through the use of a high-throughput and cost-effective method, DNA Mass Spectrometry. J Hum Genet. 2018;63(1):1-8.
  18. Hsu TR, Niu DM*. Fabry disease: Review and experience during newborn screening. Trends Cardiovasc Med. 2017. pii: S1050-1738(17)30162-7.
  19. Hwang HE, Hsu TR, Lee YH, Wang HK, Chiou HJ, Niu DM. Muscle ultrasound: A useful tool in newborn screening for infantile onset pompe disease. 2017;96(44):e8415
  20. Liao HC, Hsu TR, Young L, Chiang CC, Huang CK, Liu HC, Niu DM*, Chen YJ. Functional and biological studies of α-galactosidase A variants with uncertain significance from newborn screening in Taiwan. Mol Genet Metab. 2017. pii: S1096-7192(17)30141-5.
  21. Liao HC, Chan MJ, Yang CF, Chiang CC, Niu DM, Huang CK, Gelb MH. Mass Spectrometry but Not Fluorimetry Distinguishes Affected and Pseudodeficiency Patients in Newborn Screening for Pompe Disease. Clin Chem. 2017. 63(7):1271-1277.
  22. Chang WH, Niu DM, Lu CY, Lin SY, Liu TC, Chang JG. Modulation the alternative splicing of GLA (IVS4+919G>A) in Fabry disease. PLoS One. 2017. 12(4):e0175929.
  23. Tsai FC, Lee HJ, Wang AG, Hsieh SC, Lu YH, Lee MC, Pai JS, Chu TH, Yang CF, Hsu TR, Lai CJ, Tsai MT, Ho PH, Lin MC, Cheng LY, Chuang YC, Niu DM*. Experiences during newborn screening for glutaric aciduria type 1: Diagnosis, treatment, genotype, phenotype, and outcomes. J Chin Med Assoc. 2017. 80(4):253-261.
  24. Chen KH, Chou YC, Hsiao CY, Chien Y, Wang KL, Lai YH, Chang YL, Niu DM, Yu WC. Amelioration of serum 8-OHdG level by enzyme replacement therapy in patients with Fabry cardiomyopathy. Biochem Biophys Res Commun. 2017. 486(2):293-299.
  25. Lee HJ, Hsu TR, Hung SC, Yu WC, Chu TH, Yang CF, Bizjajeva S, Tiu CM, Niu DM*. A comparison of central nervous system involvement in patients with classical Fabry disease or the later-onset subtype with the IVS4+919G>A mutation. BMC Neurol. 2017. 17(1):25.
  26. Auray-Blais C, Lavoie P, Boutin M, Ntwari A, Hsu TR, Huang CK, Niu DM*. Biomarkers associated with clinical manifestations in Fabry disease patients with a late-onset cardiac variant mutation. Clin Chim Acta. 2017. 466:185-193.
  27. Chou SJ, Yu WC, Chang YL, Chen WY, Chang WC, Chien Y, Yen JC, Liu YY, Chen SJ, Wang CY, Chen YH, Niu DM, Lin SJ, Chen JW, Chiou SH, Leu HB. Energy utilization of induced pluripotent stem cell-derived cardiomyocyte in Fabry disease. Int J Cardiol. 2017. pii: S0167-5273 (17) 30028-1.
  28. Hsu TR, Chang FP, Chu TH, Sung SH, Bizjajeva S, Yu WC, Niu DM*. Correlations between Endomyocardial Biopsies and Cardiac Manifestations in Taiwanese Patients with the Chinese Hotspot IVS4+919G>A Mutation: Data from the Fabry Outcome Survey. Int J Mol Sci. 2017. 68:2554-2563.
  29. Bu XM, Niu DM, Wu J, Yuan YL, Song JX, Wang JJ. Elevated levels of preβ1-high-density lipoprotein are associated with cholesterol ester transfer protein, the presence and severity of coronary artery disease. Lipids Health Dis. 2017. 16(1):4.
  30. Hsu TR, Hung SC, Chang FP, Yu WC, Sung SH, Hsu CL, Dzhagalov I, Yang CF, Chu TH, Lee HJ, Lu YH, Chang SK, Liao HC, Lin HY, Liao TC, Lee PC, Li HY, Yang AH, Ho HC, Chiang CC, Lin CY, Desnick RJ, and Niu DM*. Later-Onset Fabry Disease - Cardiac Damage Progresses in Silence - Experience with a Highly Prevalent Mutation. Journal of the American College of Cardiology. 2016. 68(23):2554-2563.
  31. Wang NH, Chen SJ, Yang CF, Chen HW, Chuang HP, Lu YH, Chen CH, Wu JY, Niu DM*, Chen YT. Homozygosity Mapping and Whole-Genome Sequencing Links a Missense Mutation in POMGNT1 to Autosomal Recessive Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 2016. 57(8):3601-9.
  32. Lin HY, Chuang CK, Huang YH, Tu RY, Lin FJ, Lin SJ, Chiu PC, Niu DM, Tsai FJ, Hwu WL, Chien YH, Lin JL, Chou YY, Tsai WH, Chang TM, Lin SP. Causes of death and clinical characteristics of 34 patients with Mucopolysaccharidosis II in Taiwan from 1995-2012. Orphanet J Rare Dis. 2016. 11(1):85.
  33. Lidove O, Barbey F, Niu DM, Brand E, Nicholls K, Bizjajeva S, Hughes DA. Fabry in the older patient: Clinical consequences and possibilities for treatment. Mol Genet Metab. 2016. 118(4):319-25.Lin HY, Chuang CK, Wang CH, Chien YH, Wang YM, Tsai FJ, Chou YY, Lin SJ, Pan HP, Niu DM, Hwu WL, Ke YY, Lin SP. Long-term galsulfase enzyme replacement therapy in Taiwanese mucopolysaccharidosis VI patients: A case series. Mol Genet Metab Rep. 2016. 18(7):63-9.
  34. Chen KH, Chien Y, Wang KL, Leu HB, Hsiao CY, Lai YH, Wang CY, Chang YL, Lin SJ, Niu DM, Chiou SH, Yu WC. Evaluation of Proinflammatory Prognostic Biomarkers for Fabry Cardiomyopathy with Enzyme Replacement Therapy. Can J Cardiol. 2015. pii: S0828-282X(15)01578-0.
  35. Lin HY, Chuang CK, Chen MR, Lin SM, Hung CL, Chang CY, Chiu PC, Tsai WH, Niu DM, Tsai FJ, Lin SJ, Hwu WL, Lin JL, Lin SP. Cardiac structure and function and effects of enzyme replacement therapy in patients with mucopolysaccharidoses I, II, IVA and VI. Mol Genet Metab. 2016. 117(4):431-7.
  36. Lee HJ, Hung SC, Hsu TR, Ko SC, Chui-Mei T, Huang CC, Niu DM, Lin CP. Brain MR Imaging Findings of Cardiac-Type Fabry Disease with an IVS4+919G>A Mutation. AJNR Am J Neuroradiol. 2016. 37(6):1044-9.
  37. Yang CF, Yang CC, Liao HC, Huang LY, Chiang CC, Ho HC, Lai CJ, Chu TH, Yang TF, Hsu TR, Soong WJ, Niu DM*. Very Early Treatment for Infantile-Onset Pompe Disease Contributes to Better Outcomes. J Pediatr. 2016. 169:174-180.
  38. Lin HY, Chuang CK, Su YN, Chen MR, Chiu HC, Niu DM, Lin SP. Genotype and phenotype analysis of Taiwanese patients with osteogenesis imperfecta. Orphanet J Rare Dis. 2015. 10:152.
  39. Liu YN, Liu TT, Fan YL, Niu DM, Chien YH, Chou YY, Lee NC, Hsiao KJ, Chiu YH. Measuring propionyl-CoA carboxylase activity in phytohaemagglutinin stimulated lymphocytes using high performance liquid chromatography. Clin Chim Acta. 2015. pii: S0009-8981(15)30060-7.
  40. Lin HY, Chuang CK, Chen YJ, Tu RY, Chen MR, Niu DM, Lin SP. Functional independence of Taiwanese children with Down syndrome. Dev Med Child Neurol. 2015. 58(5):502-7.
  41. Huang CH, Chiu PC, Liu HC, Lu YH, Huang JK, Charng MJ, Niu DM*. Clinical observations and treatment of pediatric homozygous familial hypercholesterolemia due to a low-density lipoprotein receptor defect. J Clin Lipidol. 2015. 9(2):234-40.
  42. Liu HC, Perrin A, Hsu TR, Yang CF, Lin HY, Yu WC, Niu DM*. Age at First Cardiac Symptoms in Fabry Disease: Association with a Chinese Hotspot Fabry Mutation (IVS4+919G>A), Classical Fabry Mutations, and Sex in a Taiwanese Population from the Fabry Outcome Survey (FOS). JIMD Rep. 2015. 22:107-13.
  43. Lu YH, Cheng LM, Huang YH, Lo MY, Wu TJ, Lin HY, Hsu TR, Niu DM*. Heterozygous carriers of classical homocystinuria tend to have higher fasting serum homocysteine concentrations than non-carriers in the presence of folate deficiency. Clin Nutr. 2015. 6:1155-8. 

 

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